Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios

doi:10.1002/ajmg.b.30025

IR@PKUHSC > 北京大学精神卫生研究所

学科主题	精神卫生
	Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios
	Shuang, M; Liu, J; Jia, MX; Yang, JZ; Wu, SP; Gong, XH; Ling, YS; Ruan, Y; Yang, XL; Zhang, D
关键词	association study glutamate receptor 6 autism single nucleotide polymorphism
刊名	AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
	2004-11-15
DOI	10.1002/ajmg.b.30025
卷	131B 期:1 页:48-50
收录类别	SCI
文章类型	Article
WOS标题词	Science & Technology
类目[WOS]	Genetics & Heredity ; Psychiatry
研究领域[WOS]	Genetics & Heredity ; Psychiatry
关键词[WOS]	KAINATE ; RECEPTORS ; DISORDER ; HISTORY ; LINKAGE ; TWIN
英文摘要	The glutamate pathways are involved in diverse processes such as learning and memory, epilepsy, and they play important roles in neural plasticity, neural development, and neurodegeneration. It has been proposed that autism could be a hypoglutamatergic disorder. Recently, Jamain et al. [Mol Psychiatry 7:302-310] reported that the glutamate receptor 6 (GluR6 or GRIK2) is in linkage disequilibrium. with autism. In the present study, the transmission disequilibrium test (TDT) and the haplotype transmission were performed to analyze the four SNPs (SNP1: rs995640; SNP2: rs2227281; SNP3: rs2227283; SNP4: rs2235076) of GluR6 in 174 Chinese Han parent-offspring trios. The TDT demonstrated that the two SNPs (SNP2 and SNP3) showed preferential transmission (TDT P=0.032). The global chi(2) test for haplotype transmission also revealed an association between GluR6 and autism (chi(2)=10.78, df=3, P=0.013). Our results suggested that GluR6 is in linkage disequilibrium with autism. (C) 2004 Wiley-Liss, Inc.
语种	英语
WOS记录号	WOS:000224790900009
引用统计	被引频次：69[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.bjmu.edu.cn/handle/400002259/63787
专题	北京大学精神卫生研究所
作者单位	Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Shuang, M,Liu, J,Jia, MX,et al. Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2004,131B(1):48-50.
APA	Shuang, M.,Liu, J.,Jia, MX.,Yang, JZ.,Wu, SP.,...&Zhang, D.(2004).Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,131B(1),48-50.
MLA	Shuang, M,et al."Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 131B.1(2004):48-50.