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Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios
Shuang, M; Liu, J; Jia, MX; Yang, JZ; Wu, SP; Gong, XH; Ling, YS; Ruan, Y; Yang, XL; Zhang, D
关键词association study glutamate receptor 6 autism single nucleotide polymorphism
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2004-11-15
DOI10.1002/ajmg.b.30025
131B期:1页:48-50
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]KAINATE ; RECEPTORS ; DISORDER ; HISTORY ; LINKAGE ; TWIN
英文摘要

The glutamate pathways are involved in diverse processes such as learning and memory, epilepsy, and they play important roles in neural plasticity, neural development, and neurodegeneration. It has been proposed that autism could be a hypoglutamatergic disorder. Recently, Jamain et al. [Mol Psychiatry 7:302-310] reported that the glutamate receptor 6 (GluR6 or GRIK2) is in linkage disequilibrium. with autism. In the present study, the transmission disequilibrium test (TDT) and the haplotype transmission were performed to analyze the four SNPs (SNP1: rs995640; SNP2: rs2227281; SNP3: rs2227283; SNP4: rs2235076) of GluR6 in 174 Chinese Han parent-offspring trios. The TDT demonstrated that the two SNPs (SNP2 and SNP3) showed preferential transmission (TDT P=0.032). The global chi(2) test for haplotype transmission also revealed an association between GluR6 and autism (chi(2)=10.78, df=3, P=0.013). Our results suggested that GluR6 is in linkage disequilibrium with autism. (C) 2004 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000224790900009
引用统计
被引频次:69[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63787
专题北京大学精神卫生研究所
作者单位Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Shuang, M,Liu, J,Jia, MX,et al. Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2004,131B(1):48-50.
APA Shuang, M.,Liu, J.,Jia, MX.,Yang, JZ.,Wu, SP.,...&Zhang, D.(2004).Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,131B(1),48-50.
MLA Shuang, M,et al."Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 131B.1(2004):48-50.
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