| 学科主题 | 精神卫生 |
| Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios | |
| Shuang, M; Liu, J; Jia, MX; Yang, JZ; Wu, SP; Gong, XH; Ling, YS; Ruan, Y; Yang, XL; Zhang, D | |
| 关键词 | association study glutamate receptor 6 autism single nucleotide polymorphism |
| 刊名 | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
 |
| 2004-11-15 | |
| DOI | 10.1002/ajmg.b.30025 |
| 卷 | 131B期:1页:48-50 |
| 收录类别 | SCI |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Genetics & Heredity ; Psychiatry |
| 研究领域[WOS] | Genetics & Heredity ; Psychiatry |
| 关键词[WOS] | KAINATE ; RECEPTORS ; DISORDER ; HISTORY ; LINKAGE ; TWIN |
| 英文摘要 | The glutamate pathways are involved in diverse processes such as learning and memory, epilepsy, and they play important roles in neural plasticity, neural development, and neurodegeneration. It has been proposed that autism could be a hypoglutamatergic disorder. Recently, Jamain et al. [Mol Psychiatry 7:302-310] reported that the glutamate receptor 6 (GluR6 or GRIK2) is in linkage disequilibrium. with autism. In the present study, the transmission disequilibrium test (TDT) and the haplotype transmission were performed to analyze the four SNPs (SNP1: rs995640; SNP2: rs2227281; SNP3: rs2227283; SNP4: rs2235076) of GluR6 in 174 Chinese Han parent-offspring trios. The TDT demonstrated that the two SNPs (SNP2 and SNP3) showed preferential transmission (TDT P=0.032). The global chi(2) test for haplotype transmission also revealed an association between GluR6 and autism (chi(2)=10.78, df=3, P=0.013). Our results suggested that GluR6 is in linkage disequilibrium with autism. (C) 2004 Wiley-Liss, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000224790900009 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/63787 |
| Collection | 北京大学精神卫生研究所 |
| 作者单位 | Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China |
| Recommended Citation GB/T 7714 | Shuang, M,Liu, J,Jia, MX,et al. Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2004,131B(1):48-50. |
| APA | Shuang, M.,Liu, J.,Jia, MX.,Yang, JZ.,Wu, SP.,...&Zhang, D.(2004).Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,131B(1),48-50. |
| MLA | Shuang, M,et al."Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 131B.1(2004):48-50. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment