IR@PKUHSC  > 中国药物依赖性研究所
学科主题药物依赖
PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3
Shi, Hai-Shui1,2,3; Zhu, Wei-Li1; Liu, Jian-Feng1; Luo, Yi-Xiao1; Si, Ji-Jian1; Wang, Shen-Jun1; Xue, Yan-Xue1; Ding, Zeng-Bo1; Shi, Jie1; Lu, Lin1,4
关键词depression neuropeptide trefoil factor 3 basolateral amygdala phosphatidylinositol 3-kinase chronic mild stress
刊名NEUROPSYCHOPHARMACOLOGY
2012-11-01
DOI10.1038/npp.2012.131
37期:12页:2671-2683
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]CHRONIC MILD STRESS ; LONG-TERM POTENTIATION ; HUMAN HYPOTHALAMUS ; ANXIETY DISORDERS ; DENTATE GYRUS ; THERAPEUTIC TARGETS ; BEHAVIORAL DESPAIR ; MOOD DISORDERS ; TFF3 PEPTIDE ; ANIMAL-MODEL
英文摘要

Depression is one of the most common and debilitating psychiatric illnesses around the world, but the current antidepressants used to treat depression have many limitations. Progressively more studies have shown that neuropeptide systems are potential novel therapeutic targets for depression. However, whether the neuropeptide trefoil factor 3 (TFF3) participates in the development of depression has not been examined. In the current experiments, we assessed the antidepressant effects of TFF3 using the forced swim test (FST), tail suspension test (TST), and chronic mild stress (CMS) paradigm. Furthermore, we determined the mechanism that underlies the antidepressant-like effects of TFF3 in the rat FST. TFF3 dose-dependently reduced immobility time in both FST and TST. CMS elevated plasma TFF3 and decreased basolateral amygdala (BLA) TFF3 levels in rats, and acute TFF3 (0.1 mg/kg, i.p.) treatment reversed the depressive-like behaviors induced by CMS. Furthermore, TFF3 (0.1 mg/kg, i.p.) significantly increased Fos expression in the BLA, medial prefrontal cortex, and hypothalamus in rats subjected to the FST. Intra-BLA infusions of TFF3 (1 ng/side) exerted rapid antidepressant-like effects in the rat FST. Additionally, acute systemic TFF3 administration increased the level of phosphorylated-Akt (p-Akt) in the BLA. Finally, intra-BLA infusions of LY294002 (5 mM/side), a specific phosphatidylinositol 3-kinase (PI3K) inhibitor, significantly blocked the antidepressant-like effect of TFF3. Our results demonstrated that TFF3 exerts antidepressant-like effects that might be mediated by the PI3K/Akt signaling pathway in the BLA. These findings suggest a novel neuropeptide system target in the development of new antidepressants. Neuropsychopharmacology (2012) 37, 2671-2683; doi:10.1038/npp.2012.131; published online 25 July 2012

语种英语
WOS记录号WOS:000310054700014
项目编号2009CB522004 ; 30800362 ; 81071079 ; 20121323120002 ; 2012ZX09103301
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Specific Foundation for Doctoral Institute Program from the State Education Ministry of China ; National Science and Technology Major Project
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63791
专题中国药物依赖性研究所
作者单位1.Minist Hlth, Key Lab Neurosci, Minist Educ, Beijing, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Hebei Med Univ, Dept Biochem & Mol Biol, Basic Med Coll, Shijiazhuang, Peoples R China
4.Hebei Med Univ, Hebei Key Lab Med Biotechnol, Shijiazhuang, Peoples R China
推荐引用方式
GB/T 7714
Shi, Hai-Shui,Zhu, Wei-Li,Liu, Jian-Feng,et al. PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3[J]. NEUROPSYCHOPHARMACOLOGY,2012,37(12):2671-2683.
APA Shi, Hai-Shui.,Zhu, Wei-Li.,Liu, Jian-Feng.,Luo, Yi-Xiao.,Si, Ji-Jian.,...&Lu, Lin.(2012).PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3.NEUROPSYCHOPHARMACOLOGY,37(12),2671-2683.
MLA Shi, Hai-Shui,et al."PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3".NEUROPSYCHOPHARMACOLOGY 37.12(2012):2671-2683.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shi, Hai-Shui]的文章
[Zhu, Wei-Li]的文章
[Liu, Jian-Feng]的文章
百度学术
百度学术中相似的文章
[Shi, Hai-Shui]的文章
[Zhu, Wei-Li]的文章
[Liu, Jian-Feng]的文章
必应学术
必应学术中相似的文章
[Shi, Hai-Shui]的文章
[Zhu, Wei-Li]的文章
[Liu, Jian-Feng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。