IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Improved biological characteristics of poly(L-lactic acid) electrospun membrane by incorporation of multiwalled carbon nanotubes/hydroxyapatite nanoparticles
Mei, Fang; Zhong, Jinsheng; Yang, Xiaoping; Ouyang, Xiangying; Zhang, Shen; Hu, Xiaoyang; Ma, Qi; Lu, Jigui; Ryu, Seungkon; Deng, Xuliang
刊名BIOMACROMOLECULES
2007-12-01
DOI10.1021/bm7006295
8期:12页:3729-3735
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]GUIDED TISSUE REGENERATION ; HUMAN GINGIVAL FIBROBLASTS ; CELL-PROLIFERATION ; MECHANICAL-PROPERTIES ; NANOTUBES ; HYDROXYAPATITE ; SCAFFOLD ; FIBERS ; BIOCOMPATIBILITY ; OSTEOBLASTS
英文摘要

Significant effort has been devoted to fabricating various biomaterials to satisfy specific clinical requirements. In this study, we developed a new type of guided tissue regeneration (GTR) membrane by electrospinning a suspension consisting of poly(L-lactic acid), multiwalled carbon nanotubes, and hydroxyapatite (PLLA/MWNTs/HA). MWNTs/HA nanoparticles were uniformly dispersed in the membranes, and the degradation characteristics were far improved. Cytologic research revealed that the PLLA/MWNTs/HA membrane enhanced the adhesion and proliferation of periodontal ligament cells (PDLCs) by 30% and inhibited the adhesion and proliferation of gingival epithelial cells by 30% also, compared with the control group. After PDLCs were seeded into the PLLA/MWNTs/HA membrane, cell/membrane composites were implanted into the leg muscle pouches of immunodeficient mice. Histologic examinations showed that PDLCs attached on the membranes functioned well in vivo. This new type of membrane shows excellent dual biological functions and satisfied the requirement of the GTR technique successfully in spite of a monolayer structure. Compared with other GTR membranes on sale or in research, the membrane can simplify the manufacturing process, reduce the fabrication cost, and avoid possible mistakes in clinical application. Moreover, it does not need to be taken out after surgery. PLLA/MWNTs/HA membranes have shown great potential for GTR and tissue engineering.

语种英语
WOS记录号WOS:000251547600008
Citation statistics
Cited Times:107[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63792
Collection北京大学基础医学院
作者单位1.Beijing Univ Chem & Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
4.Chungnam Natl Univ, Dept Chem Engn, Taejon 305764, South Korea
Recommended Citation
GB/T 7714
Mei, Fang,Zhong, Jinsheng,Yang, Xiaoping,et al. Improved biological characteristics of poly(L-lactic acid) electrospun membrane by incorporation of multiwalled carbon nanotubes/hydroxyapatite nanoparticles[J]. BIOMACROMOLECULES,2007,8(12):3729-3735.
APA Mei, Fang.,Zhong, Jinsheng.,Yang, Xiaoping.,Ouyang, Xiangying.,Zhang, Shen.,...&Deng, Xuliang.(2007).Improved biological characteristics of poly(L-lactic acid) electrospun membrane by incorporation of multiwalled carbon nanotubes/hydroxyapatite nanoparticles.BIOMACROMOLECULES,8(12),3729-3735.
MLA Mei, Fang,et al."Improved biological characteristics of poly(L-lactic acid) electrospun membrane by incorporation of multiwalled carbon nanotubes/hydroxyapatite nanoparticles".BIOMACROMOLECULES 8.12(2007):3729-3735.
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