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学科主题: 基础医学
题名:
Improved biological characteristics of poly(L-lactic acid) electrospun membrane by incorporation of multiwalled carbon nanotubes/hydroxyapatite nanoparticles
作者: Mei, Fang; Zhong, Jinsheng; Yang, Xiaoping; Ouyang, Xiangying; Zhang, Shen; Hu, Xiaoyang; Ma, Qi; Lu, Jigui; Ryu, Seungkon; Deng, Xuliang
刊名: BIOMACROMOLECULES
发表日期: 2007-12-01
DOI: 10.1021/bm7006295
卷: 8, 期:12, 页:3729-3735
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]: GUIDED TISSUE REGENERATION ; HUMAN GINGIVAL FIBROBLASTS ; CELL-PROLIFERATION ; MECHANICAL-PROPERTIES ; NANOTUBES ; HYDROXYAPATITE ; SCAFFOLD ; FIBERS ; BIOCOMPATIBILITY ; OSTEOBLASTS
英文摘要:

Significant effort has been devoted to fabricating various biomaterials to satisfy specific clinical requirements. In this study, we developed a new type of guided tissue regeneration (GTR) membrane by electrospinning a suspension consisting of poly(L-lactic acid), multiwalled carbon nanotubes, and hydroxyapatite (PLLA/MWNTs/HA). MWNTs/HA nanoparticles were uniformly dispersed in the membranes, and the degradation characteristics were far improved. Cytologic research revealed that the PLLA/MWNTs/HA membrane enhanced the adhesion and proliferation of periodontal ligament cells (PDLCs) by 30% and inhibited the adhesion and proliferation of gingival epithelial cells by 30% also, compared with the control group. After PDLCs were seeded into the PLLA/MWNTs/HA membrane, cell/membrane composites were implanted into the leg muscle pouches of immunodeficient mice. Histologic examinations showed that PDLCs attached on the membranes functioned well in vivo. This new type of membrane shows excellent dual biological functions and satisfied the requirement of the GTR technique successfully in spite of a monolayer structure. Compared with other GTR membranes on sale or in research, the membrane can simplify the manufacturing process, reduce the fabrication cost, and avoid possible mistakes in clinical application. Moreover, it does not need to be taken out after surgery. PLLA/MWNTs/HA membranes have shown great potential for GTR and tissue engineering.

语种: 英语
WOS记录号: WOS:000251547600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63792
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Beijing Univ Chem & Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
4.Chungnam Natl Univ, Dept Chem Engn, Taejon 305764, South Korea

Recommended Citation:
Mei, Fang,Zhong, Jinsheng,Yang, Xiaoping,et al. Improved biological characteristics of poly(L-lactic acid) electrospun membrane by incorporation of multiwalled carbon nanotubes/hydroxyapatite nanoparticles[J]. BIOMACROMOLECULES,2007,8(12):3729-3735.
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