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学科主题: 精神卫生
题名:
Proton magnetic resonance spectroscopy revealed differences in the glutamate plus glutamine/creatine ratio of the anterior cingulate cortex between healthy and pediatric post-traumatic stress disorder patients diagnosed after 2008 Wenchuan earthquake
作者: Yang, Zhi-Yong1,2,3; Quan, Hong1,2; Peng, Zu-Lai4; Zhong, Yang1,2; Tan, Zhi-Jie1,2; Gong, Qi-Yong5
关键词: anterior cingulate cortex ; glutamate and glutamine ; neuroimage ; pediatric post-traumatic stress disorder ; proton magnetic resonance spectroscopy
刊名: PSYCHIATRY AND CLINICAL NEUROSCIENCES
发表日期: 2015-12-01
DOI: 10.1111/pcn.12332
卷: 69, 期:12, 页:782-790
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: N-ACETYLASPARTATE ; BRAIN ; HIPPOCAMPUS ; PTSD ; TRAUMA ; SCHIZOPHRENIA ; VULNERABILITY ; METAANALYSIS ; PREDICTORS ; SURVIVORS
英文摘要:

AimsEarthquakes always leave many surviving teenagers suffering from various mental problems, such as post-traumatic stress disorder (PTSD). We studied the metabolites in current and remitted pediatric PTSD patients and healthy controls after an earthquake, aiming to find the neurochemistry differences in these teenagers.

MethodsProton magnetic resonance spectroscopy (H-1-MRS) was performed in the anterior cingulate cortex (ACC) of 21 healthy, 10 PTSD and 23 remitted subjects.

ResultsSignificantly lower glutamate+glutamine/creatine (Glx/Cr) levels in the ACC (1.150.14 vs 1.37 +/- 0.08, P=0.047) were found in PTSD subjects relative to remitted subjects; and significantly lower Glx/Cr levels in the ACC (1.37 +/- 0.08 vs 1.59 +/- 0.10, P=0.045) were found in remitted subjects relative to healthy controls.

ConclusionsOur findings imply that the Glx/Cr ratio in the ACC can be used to differentiate not only between healthy and pediatric PTSD patients, but also between the current and remitted phases of pediatric PTSD. The changes in the Glx/Cr ratio may be caused by brain dysfunction in the current phase and recovery in the remitted phase.

语种: 英语
所属项目编号: 10875092 ; 11175132 ; 2012FKB04449
项目资助者: Natural Science Foundation of China ; Natural Science Foundation of Hubei province of China
WOS记录号: WOS:000365813400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63797
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Wuhan Univ, Sch Phys & Technol, Lab Biol & Med Phys, Wuhan 430072, Peoples R China
3.Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan 430072, Peoples R China
4.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Ctr Canc, Wuhan 430074, Peoples R China
5.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr, Dept Radiol, Chengdu 610064, Peoples R China

Recommended Citation:
Yang, Zhi-Yong,Quan, Hong,Peng, Zu-Lai,et al. Proton magnetic resonance spectroscopy revealed differences in the glutamate plus glutamine/creatine ratio of the anterior cingulate cortex between healthy and pediatric post-traumatic stress disorder patients diagnosed after 2008 Wenchuan earthquake[J]. PSYCHIATRY AND CLINICAL NEUROSCIENCES,2015,69(12):782-790.
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