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Proton magnetic resonance spectroscopy revealed differences in the glutamate plus glutamine/creatine ratio of the anterior cingulate cortex between healthy and pediatric post-traumatic stress disorder patients diagnosed after 2008 Wenchuan earthquake
Yang, Zhi-Yong1,2,3; Quan, Hong1,2; Peng, Zu-Lai4; Zhong, Yang1,2; Tan, Zhi-Jie1,2; Gong, Qi-Yong5
关键词anterior cingulate cortex glutamate and glutamine neuroimage pediatric post-traumatic stress disorder proton magnetic resonance spectroscopy
刊名PSYCHIATRY AND CLINICAL NEUROSCIENCES
2015-12-01
DOI10.1111/pcn.12332
69期:12页:782-790
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Psychiatry
关键词[WOS]N-ACETYLASPARTATE ; BRAIN ; HIPPOCAMPUS ; PTSD ; TRAUMA ; SCHIZOPHRENIA ; VULNERABILITY ; METAANALYSIS ; PREDICTORS ; SURVIVORS
英文摘要

AimsEarthquakes always leave many surviving teenagers suffering from various mental problems, such as post-traumatic stress disorder (PTSD). We studied the metabolites in current and remitted pediatric PTSD patients and healthy controls after an earthquake, aiming to find the neurochemistry differences in these teenagers.

MethodsProton magnetic resonance spectroscopy (H-1-MRS) was performed in the anterior cingulate cortex (ACC) of 21 healthy, 10 PTSD and 23 remitted subjects.

ResultsSignificantly lower glutamate+glutamine/creatine (Glx/Cr) levels in the ACC (1.150.14 vs 1.37 +/- 0.08, P=0.047) were found in PTSD subjects relative to remitted subjects; and significantly lower Glx/Cr levels in the ACC (1.37 +/- 0.08 vs 1.59 +/- 0.10, P=0.045) were found in remitted subjects relative to healthy controls.

ConclusionsOur findings imply that the Glx/Cr ratio in the ACC can be used to differentiate not only between healthy and pediatric PTSD patients, but also between the current and remitted phases of pediatric PTSD. The changes in the Glx/Cr ratio may be caused by brain dysfunction in the current phase and recovery in the remitted phase.

语种英语
WOS记录号WOS:000365813400006
项目编号10875092 ; 11175132 ; 2012FKB04449
资助机构Natural Science Foundation of China ; Natural Science Foundation of Hubei province of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63797
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Wuhan Univ, Sch Phys & Technol, Lab Biol & Med Phys, Wuhan 430072, Peoples R China
3.Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan 430072, Peoples R China
4.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Ctr Canc, Wuhan 430074, Peoples R China
5.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr, Dept Radiol, Chengdu 610064, Peoples R China
推荐引用方式
GB/T 7714
Yang, Zhi-Yong,Quan, Hong,Peng, Zu-Lai,et al. Proton magnetic resonance spectroscopy revealed differences in the glutamate plus glutamine/creatine ratio of the anterior cingulate cortex between healthy and pediatric post-traumatic stress disorder patients diagnosed after 2008 Wenchuan earthquake[J]. PSYCHIATRY AND CLINICAL NEUROSCIENCES,2015,69(12):782-790.
APA Yang, Zhi-Yong,Quan, Hong,Peng, Zu-Lai,Zhong, Yang,Tan, Zhi-Jie,&Gong, Qi-Yong.(2015).Proton magnetic resonance spectroscopy revealed differences in the glutamate plus glutamine/creatine ratio of the anterior cingulate cortex between healthy and pediatric post-traumatic stress disorder patients diagnosed after 2008 Wenchuan earthquake.PSYCHIATRY AND CLINICAL NEUROSCIENCES,69(12),782-790.
MLA Yang, Zhi-Yong,et al."Proton magnetic resonance spectroscopy revealed differences in the glutamate plus glutamine/creatine ratio of the anterior cingulate cortex between healthy and pediatric post-traumatic stress disorder patients diagnosed after 2008 Wenchuan earthquake".PSYCHIATRY AND CLINICAL NEUROSCIENCES 69.12(2015):782-790.
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