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Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population
Zhou, X. -J.; Lv, J. -C.; Cheng, W. -R.; Yu, L.; Zhao, M. -H.; Zhang, H.1
关键词Chinese lupus nephritis TLR9
刊名CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
2010-05-01
28期:3页:397-400
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
资助者National Natural Science Foundation of China ; Foundation of Ministry of Health of China ; National Natural Science Foundation of China ; Foundation of Ministry of Health of China
研究领域[WOS]Rheumatology
关键词[WOS]TOLL-LIKE RECEPTOR-9 ; KIDNEY-DISEASE ; RENAL-DISEASE ; MURINE LUPUS ; ERYTHEMATOSUS ; TOLL-LIKE-RECEPTOR-9 ; SUSCEPTIBILITY ; ACTIVATION ; EXPRESSION
英文摘要

Objective. Although increasing data have supported the possible role of TLR-9 in the pathogenesis of lupus nephritis (LN), the effect of TLR-9 on the lupus phenotype remains controversial. The aim of this study was to associate common variants in the TLR9 gene with susceptibility to lupus nephritis in the Chinese population to further ascertain whether it is a susceptible locus for SLE, especially its likely role in LN from a comparatively large population.

Methods. Two previously reported SLE associated single nucleotide polymorphism (rs352139, rs352140) were investigated in a case-control study comprised of 315 patients with biopsy proven lupus nephritis and 338 matched healthy controls. Single nucleotide polymorphisms (SNPs) were typed by TaqMan allele discrimination assays.

Results. Both rs352139 (p=0.040, OR: 0.713, 95%CI: 0.516-0.985) and rs352140 ( p=0.048, OR: 0.723, 95%CI : 0.525-0.997) were associated with LN in dominant model. A trend for an association between genotypes and the disease activity indexes was observed. However, no significance was achieved.

Conclusions. The present study suggested that TLR9 gene have a role in establishing an autoimmune background and pathogenesis in human LN.

语种英语
所属项目编号30801022 ; 30825021 ; 200802052
资助者National Natural Science Foundation of China ; Foundation of Ministry of Health of China ; National Natural Science Foundation of China ; Foundation of Ministry of Health of China
WOS记录号WOS:000280177500017
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63800
专题北京大学第一临床医学院_肾脏内科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Div Renal, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhou, X. -J.,Lv, J. -C.,Cheng, W. -R.,et al. Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2010,28(3):397-400.
APA Zhou, X. -J.,Lv, J. -C.,Cheng, W. -R.,Yu, L.,Zhao, M. -H.,&Zhang, H..(2010).Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population.CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,28(3),397-400.
MLA Zhou, X. -J.,et al."Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population".CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 28.3(2010):397-400.
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