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学科主题: 临床医学
题名:
Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population
作者: Zhou, X. -J.; Lv, J. -C.; Cheng, W. -R.; Yu, L.; Zhao, M. -H.; Zhang, H.1
关键词: Chinese ; lupus nephritis ; TLR9
刊名: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
发表日期: 2010-05-01
卷: 28, 期:3, 页:397-400
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: TOLL-LIKE RECEPTOR-9 ; KIDNEY-DISEASE ; RENAL-DISEASE ; MURINE LUPUS ; ERYTHEMATOSUS ; TOLL-LIKE-RECEPTOR-9 ; SUSCEPTIBILITY ; ACTIVATION ; EXPRESSION
英文摘要:

Objective. Although increasing data have supported the possible role of TLR-9 in the pathogenesis of lupus nephritis (LN), the effect of TLR-9 on the lupus phenotype remains controversial. The aim of this study was to associate common variants in the TLR9 gene with susceptibility to lupus nephritis in the Chinese population to further ascertain whether it is a susceptible locus for SLE, especially its likely role in LN from a comparatively large population.

Methods. Two previously reported SLE associated single nucleotide polymorphism (rs352139, rs352140) were investigated in a case-control study comprised of 315 patients with biopsy proven lupus nephritis and 338 matched healthy controls. Single nucleotide polymorphisms (SNPs) were typed by TaqMan allele discrimination assays.

Results. Both rs352139 (p=0.040, OR: 0.713, 95%CI: 0.516-0.985) and rs352140 ( p=0.048, OR: 0.723, 95%CI : 0.525-0.997) were associated with LN in dominant model. A trend for an association between genotypes and the disease activity indexes was observed. However, no significance was achieved.

Conclusions. The present study suggested that TLR9 gene have a role in establishing an autoimmune background and pathogenesis in human LN.

语种: 英语
所属项目编号: 30801022 ; 30825021 ; 200802052
项目资助者: National Natural Science Foundation of China ; Foundation of Ministry of Health of China
WOS记录号: WOS:000280177500017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63800
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Div Renal, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhou, X. -J.,Lv, J. -C.,Cheng, W. -R.,et al. Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2010,28(3):397-400.
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