IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes
He, Wenqiang; Chen, Hongbin; Zhao, Chunjiang; Zhang, Feifei; Li, Henan; Wang, Qi; Wang, Xiaojuan; Wang, Hui
关键词Staphylococcus aureus Bacteraemia Genotype Toxin genes
刊名INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
2013-09-01
DOI10.1016/j.ijantimicag.2013.04.031
42期:3页:211-219
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]METHICILLIN-RESISTANT ; IDENTIFICATION ; PNEUMONIA ; INFECTION ; STRAINS ; CLONES ; SYSTEM ; MEC
英文摘要

Staphylococcus aureus from bacteraemia at multiple hospitals in China were genetically characterised to improve understanding of its epidemiology. A total of 236 consecutive, non-duplicate S. aureus bacteraemia isolates were collected at 16 Chinese hospitals. Isolates were characterised by antimicrobial resistance, 19 toxin genes, agr alleles, multilocus sequence typing and spa typing. The prevalence of meticillin-resistant S. aureus (MRSA) was 47.5% (112/236). Forty-two sequence types (STs) and 63 spa types were identified, including 14 STs and 14 spa types for MRSA. Clonal complex (CC) 8, CC5, ST7 and CC188 accounted for 67.4% of the isolates. ST239-t030/t037-SCCmecIII-agrI was the predominant MRSA genotype (50%), followed by ST5-t002/t570-SCCmecII-agrII (8%). A vancomycin MIC = >= 1 mg/L was detected significantly more often in ST5-SCCmecII and ST239-t037-SCCmecIII, whereas rifampicin resistance was overwhelmingly associated with ST239-t030-SCCmecIII (P < 0.001). Oxacillin MICs were relatively low for ST59-MRSA. Major genotypes of meticillin-susceptible S. aureus (MSSA) were ST7-t091/t796-agrI (16.1%), ST188-t189-agrI (12.1%) and ST398-t571/t034-agrI (5.6%). Toxin genes were identified in 95.8% of isolates and formed 89 toxin gene profiles. The toxin genes sea, selk, selq and sell were significantly more common in MRSA, whilst tsst-1, seb, sed, selm, seln, selp and selj were more prevalent in MSSA (P < 0.001). The pvl gene was more commonly detected in CC59, whereas tsst-1 was more frequent in CC15, CC188 and ST398 (P < 0.001). The major genotypes were associated with specific antimicrobial resistance and toxin gene profiles. (C) 2013 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

语种英语
WOS记录号WOS:000324037500003
项目编号30971571 ; 31100106 ; 7102130 ; NCET-10-0205
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63802
专题北京大学第二临床医学院
北京大学第二临床医学院_检验科
作者单位Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
He, Wenqiang,Chen, Hongbin,Zhao, Chunjiang,et al. Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2013,42(3):211-219.
APA He, Wenqiang.,Chen, Hongbin.,Zhao, Chunjiang.,Zhang, Feifei.,Li, Henan.,...&Wang, Hui.(2013).Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes.INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,42(3),211-219.
MLA He, Wenqiang,et al."Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes".INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 42.3(2013):211-219.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[He, Wenqiang]的文章
[Chen, Hongbin]的文章
[Zhao, Chunjiang]的文章
百度学术
百度学术中相似的文章
[He, Wenqiang]的文章
[Chen, Hongbin]的文章
[Zhao, Chunjiang]的文章
必应学术
必应学术中相似的文章
[He, Wenqiang]的文章
[Chen, Hongbin]的文章
[Zhao, Chunjiang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。