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学科主题: 临床医学
题名:
Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes
作者: He, Wenqiang; Chen, Hongbin; Zhao, Chunjiang; Zhang, Feifei; Li, Henan; Wang, Qi; Wang, Xiaojuan; Wang, Hui
关键词: Staphylococcus aureus ; Bacteraemia ; Genotype ; Toxin genes
刊名: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
发表日期: 2013-09-01
DOI: 10.1016/j.ijantimicag.2013.04.031
卷: 42, 期:3, 页:211-219
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: METHICILLIN-RESISTANT ; IDENTIFICATION ; PNEUMONIA ; INFECTION ; STRAINS ; CLONES ; SYSTEM ; MEC
英文摘要:

Staphylococcus aureus from bacteraemia at multiple hospitals in China were genetically characterised to improve understanding of its epidemiology. A total of 236 consecutive, non-duplicate S. aureus bacteraemia isolates were collected at 16 Chinese hospitals. Isolates were characterised by antimicrobial resistance, 19 toxin genes, agr alleles, multilocus sequence typing and spa typing. The prevalence of meticillin-resistant S. aureus (MRSA) was 47.5% (112/236). Forty-two sequence types (STs) and 63 spa types were identified, including 14 STs and 14 spa types for MRSA. Clonal complex (CC) 8, CC5, ST7 and CC188 accounted for 67.4% of the isolates. ST239-t030/t037-SCCmecIII-agrI was the predominant MRSA genotype (50%), followed by ST5-t002/t570-SCCmecII-agrII (8%). A vancomycin MIC = >= 1 mg/L was detected significantly more often in ST5-SCCmecII and ST239-t037-SCCmecIII, whereas rifampicin resistance was overwhelmingly associated with ST239-t030-SCCmecIII (P < 0.001). Oxacillin MICs were relatively low for ST59-MRSA. Major genotypes of meticillin-susceptible S. aureus (MSSA) were ST7-t091/t796-agrI (16.1%), ST188-t189-agrI (12.1%) and ST398-t571/t034-agrI (5.6%). Toxin genes were identified in 95.8% of isolates and formed 89 toxin gene profiles. The toxin genes sea, selk, selq and sell were significantly more common in MRSA, whilst tsst-1, seb, sed, selm, seln, selp and selj were more prevalent in MSSA (P < 0.001). The pvl gene was more commonly detected in CC59, whereas tsst-1 was more frequent in CC15, CC188 and ST398 (P < 0.001). The major genotypes were associated with specific antimicrobial resistance and toxin gene profiles. (C) 2013 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

语种: 英语
所属项目编号: 30971571 ; 31100106 ; 7102130 ; NCET-10-0205
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000324037500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63802
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China

Recommended Citation:
He, Wenqiang,Chen, Hongbin,Zhao, Chunjiang,et al. Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2013,42(3):211-219.
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