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学科主题: 临床医学
题名:
Variation in gene expression patterns in human gastric cancers
作者: Chen, X; Leung, SY; Yuen, ST; Chu, KM; Ji, JF; Li, R; Chan, ASY; Law, S; Troyanskaya, OG; Wong, J; So, S; Botstein, D; Brown, PO
刊名: MOLECULAR BIOLOGY OF THE CELL
发表日期: 2003-08-01
卷: 14, 期:8, 页:3208-3215
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: EPSTEIN-BARR-VIRUS ; HELICOBACTER-PYLORI INFECTION ; B-CELL LYMPHOMA ; BREAST-CANCER ; BETA-CATENIN ; CARCINOMA ; ADENOCARCINOMA ; TUMORIGENESIS ; DIFFUSE ; TUMORS
英文摘要:

Gastric cancer is the world′s second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing similar to30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.

语种: 英语
WOS记录号: WOS:000184877400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63805
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA
2.Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA
3.Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
4.Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA
5.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
6.Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
7.Perking Univ, Sch Oncol, Beijing Canc Hosp, Dept Surg, Beijing, Peoples R China

Recommended Citation:
Chen, X,Leung, SY,Yuen, ST,et al. Variation in gene expression patterns in human gastric cancers[J]. MOLECULAR BIOLOGY OF THE CELL,2003,14(8):3208-3215.
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