IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Variation in gene expression patterns in human gastric cancers
Chen, X; Leung, SY; Yuen, ST; Chu, KM; Ji, JF; Li, R; Chan, ASY; Law, S; Troyanskaya, OG; Wong, J; So, S; Botstein, D; Brown, PO
刊名MOLECULAR BIOLOGY OF THE CELL
2003-08-01
14期:8页:3208-3215
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]EPSTEIN-BARR-VIRUS ; HELICOBACTER-PYLORI INFECTION ; B-CELL LYMPHOMA ; BREAST-CANCER ; BETA-CATENIN ; CARCINOMA ; ADENOCARCINOMA ; TUMORIGENESIS ; DIFFUSE ; TUMORS
英文摘要

Gastric cancer is the world′s second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing similar to30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.

语种英语
WOS记录号WOS:000184877400012
引用统计
被引频次:201[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63805
专题北京大学临床肿瘤学院
作者单位1.Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA
2.Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA
3.Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
4.Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA
5.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
6.Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
7.Perking Univ, Sch Oncol, Beijing Canc Hosp, Dept Surg, Beijing, Peoples R China
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GB/T 7714
Chen, X,Leung, SY,Yuen, ST,et al. Variation in gene expression patterns in human gastric cancers[J]. MOLECULAR BIOLOGY OF THE CELL,2003,14(8):3208-3215.
APA Chen, X.,Leung, SY.,Yuen, ST.,Chu, KM.,Ji, JF.,...&Brown, PO.(2003).Variation in gene expression patterns in human gastric cancers.MOLECULAR BIOLOGY OF THE CELL,14(8),3208-3215.
MLA Chen, X,et al."Variation in gene expression patterns in human gastric cancers".MOLECULAR BIOLOGY OF THE CELL 14.8(2003):3208-3215.
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