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学科主题临床医学
DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology
Li, Lian1,2,3; Choi, Ji-Yeob4; Lee, Kyoung-Mu5; Sung, Hyuna4; Park, Sue K.1,2,4; Oze, Isao6; Pan, Kai-Feng7; You, Wei-Cheng7; Chen, Ying-Xuan8; Fang, Jing-Yuan8; Matsuo, Keitaro6; Kim, Woo Ho9; Yuasa, Yasuhito10; Kang, Daehee1,2,4
关键词DNA methylation blood-based biomarker serum plasma leukocyte peripheral blood
刊名JOURNAL OF EPIDEMIOLOGY
2012-09-01
DOI10.2188/jea.JE20120003
22期:5页:384-394
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]INDEPENDENT PROGNOSTIC MARKER ; CELL LUNG-CANCER ; ABERRANT PROMOTER METHYLATION ; CPG ISLAND HYPERMETHYLATION ; BREAST-CANCER ; SERUM DNA ; PLASMA DNA ; COLORECTAL-CANCER ; BLADDER-CANCER ; LEUKOCYTE DNA
英文摘要

Aberrant DNA methylation is associated with cancer development and progression. There are several types of specimens from which DNA methylation pattern can be measured and evaluated as an indicator of disease status (from normal biological process to pathologic condition) and even of pharmacologic response to therapy. Blood-based specimens such as cell-free circulating nucleic acid and DNA extracted from leukocytes in peripheral blood may be a potential source of noninvasive cancer biomarkers. In this article, we describe the characteristics of blood-based DNA methylation from different biological sources, detection methods, and the factors affecting DNA methylation. We provide a comprehensive literature review of blood-based DNA methylation as a cancer biomarker and focus on the study of DNA methylation using peripheral blood leukocytes. Although DNA methylation patterns measured in peripheral blood have great potential to be useful and informative biomarkers of cancer risk and prognosis, large systematic and unbiased prospective studies that consider biological plausibility and data analysis issues will be needed in order to develop a clinically feasible blood-based assay.

语种英语
WOS记录号WOS:000308625500002
项目编号2011-0027212
资助机构Basic Science Research Program through the National Research Foundation of Korea ; Ministry of Education, Science and Technology ; National Research Foundation of Korea (NRF) A3 Foresight program
引用统计
被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63811
专题北京大学临床肿瘤学院_流行病学研究室
作者单位1.Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul, South Korea
2.Korea Natl Open Univ, Dept Environm Hlth, Seoul, South Korea
3.Tokyo Med & Dent Univ, Dept Mol Oncol, Tokyo, Japan
4.Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 110799, South Korea
5.Tianjin Med Univ Canc Hosp & Inst, Dept Epidemiol & Biostat, Tianjin, Peoples R China
6.Seoul Natl Univ, Grad Sch, Dept Biomed Sci, Seoul, South Korea
7.Aichi Canc Ctr, Div Epidemiol & Prevent, Nagoya, Aichi 464, Japan
8.Peking Univ, Dept Canc Epidemiol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
9.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai Inst Digest Dis, Shanghai 200030, Peoples R China
10.Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 151, South Korea
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GB/T 7714
Li, Lian,Choi, Ji-Yeob,Lee, Kyoung-Mu,et al. DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology[J]. JOURNAL OF EPIDEMIOLOGY,2012,22(5):384-394.
APA Li, Lian.,Choi, Ji-Yeob.,Lee, Kyoung-Mu.,Sung, Hyuna.,Park, Sue K..,...&Kang, Daehee.(2012).DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology.JOURNAL OF EPIDEMIOLOGY,22(5),384-394.
MLA Li, Lian,et al."DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology".JOURNAL OF EPIDEMIOLOGY 22.5(2012):384-394.
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