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学科主题: 临床医学
题名:
Vaccination with transforming growth factor-beta insensitive dendritic cells suppresses pulmonary metastases of renal carcinoma in mice
作者: Tian, Feng2; Wang, Longxin2; Qin, Weijun2; Wang, Fuli2; Song, Bin2; Li, Yu3; Wen, Weihong3; Zhang, Zheng3; Zhu, Kaichang4; Zhang, Qiang5; Lee, Chung5; Zhong, Weide6; Guo, Yinglu1; Wang, He2
关键词: Dendritic cell ; Transforming growth factor-beta ; Renal carcinoma ; Vaccination ; Cancer immunotherapy
刊名: CANCER LETTERS
发表日期: 2008-11-28
DOI: 10.1016/j.canlet.2008.06.025
卷: 271, 期:2, 页:333-341
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CD8(+) T-CELLS ; TGF-BETA ; BONE-MARROW ; PROSTATE-CANCER ; TUMOR-CELLS ; HEPATOCELLULAR-CARCINOMA ; ANTITUMOR IMMUNITY ; MATURATION ; MOUSE ; ERADICATION
英文摘要:

Dendritic cells (DCs) have been widely used as cancer vaccines. However, their functional abilities have often been suppressed by tumor-secreted immunosuppressants such as transforming growth factor-beta (TGF-beta). We developed a new strategy using a TGF-beta insensitive DC as cancer vaccine. The effect of this vaccine was tested in a murine pulmonary metastases model of renal carcinoma (Renca). Tumor lysate-pulsed DCs (TP-DCs) were infected with retrovirus containing gene of dominant negative TGF-beta type II receptor (T beta RIIDN) and thus made TGF-beta insensitive. Vaccination of the mice bearing Renca pulmonary metastases with the T beta RIIDN TP-DC induced powerful tumor-specific cytotoxic T lymphocyte (CTL) responses, suppressed pulmonary metastases, and prolonged survival times. These results suggest TGF-beta-insensitive TP-DC vaccine can be used to enhance the antitumor efficacy of DC vaccine. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30300413 ; 30672097 ; D0206011000091 ; 7072084
项目资助者: Nature Science Foundation of China ; Technology Plan Emphasis Item of Peking
WOS记录号: WOS:000261010300016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63816
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Urol, Dept Urol, Beijing 100043, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Dept Urol, Xian 710032, Shaanxi Prov, Peoples R China
3.Fourth Mil Med Univ, Dept Cell Engn, Res Ctr, State Key Lab Canc Biol, Xian 710032, Shaanxi Prov, Peoples R China
4.Chinese PLA 210th Hosp, Dept Urol, Dalian 116023, Liaoning Prov, Peoples R China
5.Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA
6.First Peoples Hosp Guangzhou, Dept Urol, Guangzhou 510180, Guangdong, Peoples R China

Recommended Citation:
Tian, Feng,Wang, Longxin,Qin, Weijun,et al. Vaccination with transforming growth factor-beta insensitive dendritic cells suppresses pulmonary metastases of renal carcinoma in mice[J]. CANCER LETTERS,2008,271(2):333-341.
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