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学科主题: 药学
题名:
Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes
作者: Bi, Lanrong1; Zhao, Ming1; Gu, Keli1; Wang, Chao2; Ju, Jingfang3; Peng, Shiqi1
关键词: chemoprevention ; 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes ; anti-inflammatory activity ; structure-activity relationship
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
发表日期: 2008-02-15
DOI: 10.1016/j.bmc.2007.11.017
卷: 16, 期:4, 页:1764-1774
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: PROSTAGLANDIN G/H SYNTHASE ; COLORECTAL-CANCER ; CONFORMATIONAL EQUILIBRIA ; KETOROLAC TROMETHAMINE ; COX-2 INHIBITORS ; PREVENTION ; DRUGS ; CARCINOGENESIS ; INFLAMMATION ; CELECOXIB
英文摘要:

A new series of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes were designed and synthesized. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Sixteen of these new compounds exhibited comparable or better anti-inflammatory activities than aspirin suggesting that they can be further developed as potential anti-inflammatory drug leads. In addition, treatment with these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds. Considering their good efficacy and safety profiles, some 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes are worthy to be explored further in assessing the possible link between anti-inflammation and cancer prevention. (C) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000254080900016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63826
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100069, Peoples R China
2.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
3.Univ S Alabama, Mitchell Canc Ctr, Canc Res Inst, Mobile, AL 36688 USA

Recommended Citation:
Bi, Lanrong,Zhao, Ming,Gu, Keli,et al. Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2008,16(4):1764-1774.
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