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学科主题: 精神卫生
题名:
Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study
作者: Chen, Chao1,2; Si, Tian-Mei1,2; Xiang, Yu-Tao3,4; Ungvari, Gabor S.5; Wang, Chuan-Yue6; He, Yan-Ling7; Kua, Ee-Heok8; Fujii, Senta9; Sim, Kang10; Trivedi, Jitendra K.11; Chung, Eun-Kee12; Udomratn, Pichet13; Chee, Kok-Yoon14; Sartorius, Norman15; Tan, Chay-Hoon16; Shinfuku, Naotaka17
关键词: Asia ; Depression ; Prescription ; Prevalence ; Somatic Comorbidity
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2015-04-05
DOI: 10.4103/0366-6999.154272
卷: 128, 期:7, 页:853-858
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CORONARY-HEART-DISEASE ; BIOLOGICAL TREATMENT ; ANXIETY DISORDERS ; GENERAL HOSPITALS ; METAANALYSIS ; CHINA ; RISK ; RECOGNITION ; INPATIENTS ; CANCER
英文摘要:

Background: Depression is often comorbid with chronic somatic diseases. Few previous studies have investigated the prevalence of somatic diseases in depression or the prescription pattern of antidepressants in comorbidly depressed patients in Asia. This study aimed to investigate the prevalence of somatic comorbidity (SC) in depression and compared the prescriptions of antidepressants in depressed patients with and without SC.

Methods: A total of 2320 patients treated with antidepressants in 8 Asian countries were examined, and a diagnosis was based on the International Classification of Disease, 10th revision. We listed 17 common chronic somatic diseases. Patients′ socio-demographic and clinical characteristics and psychotropic drug prescriptions were recorded using a standardized protocol and data collection procedure.

Results: Of the patients examined, 1240 were diagnosed with depression and 30% of them (n = 375) had SC. The most common comorbid condition was diabetes (23.7%). The patients with SC were more likely to seek help at a general hospital (74.7% vs. 47.2%), and had a higher incidence of symptoms involving sadness, disturbed sleep, and poor appetite. Noradrenergic and specific serotonergic antidepressant was prescribed more for patients with SC than for those without SC (30.4% vs. 22.9%).

Conclusions: SC is common in depressed Asian patients. It is important to strengthen the recognition of depression, especially in general hospitals and when patients report some somatic discomfort. It is also a matter of urgency to establish evidence-based guidelines for the use of new antidepressants in depressed patients with SC.

语种: 英语
所属项目编号: 2011ZX09302-004 ; 20130001110106
项目资助者: "12th Five-year-plan" of National Key Technologies R and D Program of China ; Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000352533500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63830
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Minist Mental Hlth, Key Lab Mental Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Univ Macau, Fac Hlth Sci, Macau, Peoples R China
4.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
5.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
6.Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China
7.Inst Mental Hlth, Singapore, Singapore
8.CSM Med Univ, Dept Psychiat, Lucknow, Uttar Pradesh, India
9.Natl Seoul Hosp, Dept Psychiat, Seoul, South Korea
10.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
11.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
12.Capital Med Univ, Beijing Anding Hosp, Beijing 100088, Peoples R China
13.Natl Univ Singapore, Dept Psychol Med, Singapore 117548, Singapore
14.Fukushima Med Univ, Dept Disaster Psychiat, Fukushima, Japan
15.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
16.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
17.Natl Univ Singapore, Dept Pharmacol, Singapore 117548, Singapore

Recommended Citation:
Chen, Chao,Si, Tian-Mei,Xiang, Yu-Tao,et al. Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study[J]. CHINESE MEDICAL JOURNAL,2015,128(7):853-858.
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