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学科主题: 基础医学
题名:
An Antagonist for CCR4 Alleviates Murine Allergic Rhinitis by Intranasal Administration
作者: Qi, Hui1; Zheng, Yi1; Xu, Enquan1; Guo, Changyuan1; Zhang, Yan1; Sun, Qianying1; Xiao, Junhai2; Ma, Dalong1; Wang, Ying1
关键词: CCR4 ; Allergic rhinitis ; Nasal administration
刊名: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
发表日期: 2012
DOI: 10.1159/000337455
卷: 159, 期:3, 页:297-305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Allergy ; Immunology
研究领域[WOS]: Allergy ; Immunology
关键词[WOS]: REGULATORY T-CELLS ; CHEMOKINE RECEPTOR 4 ; INFLAMMATION ; ASTHMA ; EXPRESSION ; BLOCKADE ; DISEASE ; AIRWAYS ; MODEL
英文摘要:

Background: CCR4 is highly expressed on Th2 cells. These cells play an important role in acute inflammatory responses, including those involved in allergic rhinitis. We determined whether disrupting the CCR4 ligand interaction with CCR4 antagonist could alleviate allergic rhinitis in a mouse model. Methods: BALB/c mice were sensitized with ovalbumin and alum by intraperitoneal injection and challenged with intranasally administered ovalbumin. Compound 22, which has been reported as a novel small-molecule antagonist of CCR4, was also administered intranasally. In addition, budesonide, an efficient glucocorticoid, was used as a positive control. The effects of compound 22 were quantified by multiple parameters of allergic responses in both nasal and pulmonary tissues. Results: Compound 22 significantly improved symptoms of allergic rhinitis and suppressed levels of total IgE of serum. It dramatically reduced the levels of IL-4 in bronchoalveolar lavage fluid and also decreased the number of inflammatory cells in the fluid. The infiltration of inflammatory cells, especially eosinophils, was markedly reduced in the nasal and pulmonary tissues. The number of IL-4+ cells was also significantly reduced in these tissues. Moreover, the numbers of Foxp3+ cells and IL-17+ cells were reduced, though not to a statistically significant degree. Conclusions: In our research, CCR4 antagonists such as compound 22 were proven for the first time to alleviate murine allergic rhinitis when administered nasally. CCR4 antagonists may have therapeutic potential for the treatment of allergic rhinitis. Copyright (C) 2012 S. Karger AG, Basel

语种: 英语
所属项目编号: 90813025 ; 30872292 ; 81071749 ; 2009ZX09103-724 ; 2006AA02A305
项目资助者: National Natural Science Foundation of China ; National Key New Drug Creation Program of China ; National High-Tech Research and Development Program of China
WOS记录号: WOS:000305801800011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63833
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Dept Immunol, Sch Basic Med Sci,Hlth Sci Ctr, Key Lab Immunol,Minist Hlth, Beijing 100191, Peoples R China
2.Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing, Peoples R China

Recommended Citation:
Qi, Hui,Zheng, Yi,Xu, Enquan,et al. An Antagonist for CCR4 Alleviates Murine Allergic Rhinitis by Intranasal Administration[J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY,2012,159(3):297-305.
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