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学科主题临床医学
The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease
Yang, Rui; Cui, Zhao; Zhao, Juan; Zhao, Ming-Hui
关键词Anti-glomerular basement membrane disease HLA-DRB1*1501 Crescent formation
刊名CLINICAL IMMUNOLOGY
2009-11-01
DOI10.1016/j.clim.2009.07.005
133期:2页:245-250
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China
研究领域[WOS]Immunology
关键词[WOS]BASEMENT-MEMBRANE ANTIBODY ; GOODPASTURE AUTOANTIGEN ; ALPHA-3(IV) COLLAGEN ; MULTIPLE-SCLEROSIS ; NC1 DOMAIN ; HLA-DR ; SEVERITY ; GLOMERULONEPHRITIS ; IDENTIFICATION ; ASSOCIATIONS
英文摘要

Anti-glomerular basement membrane (GBM) disease, a rare autoimmune disorder, is associated with HLA-DR15 genotype in Caucasian and Japanese populations. But the distribution of HLA-DRB1 alleles in Chinese patients with anti-GBM disease and their association with clinical characteristics of anti-GBM disease are to be determined. The present study analyzed the HLA-DRB1 alleles by sequence based typing in 44 Chinese patients with anti-GBM disease and 200 healthy controls. The effects of DRB1 alleles on susceptibility to anti-GBM disease were examined by a relative predispositional effects (RPEs) method. The clinical and pathological data of the patients were collected and analyzed. The DRB1*1501 allele was significantly associated with anti-GBM disease (p = 1.597 x 10(-7)). The RPEs test also showed a significant increased frequency of DRB1*0404 in anti-GBM disease (p=0.037). Interestingly, the patients with DRB1*1501 or *0404 had more crescent formation in glomeruli than those without the two alleles (p=0.021). But the DRB1*0404 was rare in both patients and control groups, which indicates that the importance of the *0404 allele is limited in anti-GBM disease. We conclude that the HLA-DRB1*1501 allele is a genetic marker for susceptibility to anti-GBM disease. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
所属项目编号30725034 ; 30801020
资助者National Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China
WOS记录号WOS:000271167800011
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63841
Collection北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Inst Nephrol, Key Lab Renal Dis, Renal Div,Dept Med,Minist Hlth China,Hosp 1, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Yang, Rui,Cui, Zhao,Zhao, Juan,et al. The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease[J]. CLINICAL IMMUNOLOGY,2009,133(2):245-250.
APA Yang, Rui,Cui, Zhao,Zhao, Juan,&Zhao, Ming-Hui.(2009).The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease.CLINICAL IMMUNOLOGY,133(2),245-250.
MLA Yang, Rui,et al."The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease".CLINICAL IMMUNOLOGY 133.2(2009):245-250.
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