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学科主题: 公共卫生
题名:
Acute hepatitis B infection associated with drug-resistant hepatitis B virus
作者: Xu, Zhihui1; Liu, Yan1; Xu, Teng2; Chen, Li1; Si, Lanlan1; Wang, Yao1; Ren, Xiaoqiang1; Zhong, Yanwei1; Zhao, Jingmin3; Xu, Dongping1
关键词: Hepatitis B virus ; Acute hepatitis B ; Drug resistance ; Variation ; Nucleoside and nucleotide analogs
刊名: JOURNAL OF CLINICAL VIROLOGY
发表日期: 2010-08-01
DOI: 10.1016/j.jcv.2010.05.010
卷: 48, 期:4, 页:270-274
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: REVERSE-TRANSCRIPTASE ; LAMIVUDINE ; THERAPY ; HBV ; MUTATION ; RECOMMENDATIONS ; SUSCEPTIBILITY ; EVOLUTION ; VARIANTS ; ADEFOVIR
英文摘要:

Background: Pre-existing antiviral-resistant hepatitis B virus (HBV) has been associated with primary non-response to lamivudine treatment in patients with chronic hepatitis B, but little is known of the capacity for resistant HBV to cause primary infection.

Objective: The study was to investigate if Beijing patients with acute hepatitis B (AHB) are infected with drug-resistant HBV.

Study design: Sera were collected from 201 NA-untreated patients with AHB. Direct polymerase chain reaction (PCR) sequencing was used to screen HBV reverse-transcriptase (RT) domain and clonal sequencing were performed for all resistance-positive samples.

Results: Direct PCR sequencing showed that 14 samples (7.0%) were positive for drug-resistant HBV variants, comprised of 11 with the lamivudine-resistant pattern rtM204I and/or rtM204V in the presence and absence of compensatory mutations rtL80I, rtV173L, and rtL180M; two with the adefovir-resistant pattern rtA181V; and one with the entecavir-resistant pattern rtL180M + rtS202G + rtM204V. Concomitance of resistance variants with wild-type HBV was observed in samples from 13 patients. Clonal sequencing verified direct sequencing results. Furthermore, variants associated with resistance to adefovir or entecavir were found in 3 samples.

Conclusions: Drug-resistant HBV strains, including those not resistant to lamivudine, are transmissible and can cause acute hepatitis B in China. (C) 2010 Elsevier B. V. All rights reserved.

语种: 英语
所属项目编号: 7091006 ; 2007CB512803 ; 2008ZX10002-005-6 ; 2009ZX10004-314
项目资助者: Beijing Natural Science Foundation ; National Key Basic Research Developing Project ; National 11th Five-Year Special Grand Project for Infectious Diseases
WOS记录号: WOS:000279898100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63846
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Beijing 302 Hosp, Dept Pathol, Beijing 100039, Peoples R China
2.Beijing 302 Hosp, Inst Infect Dis, Viral Hepatitis Res Lab, Beijing 100039, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Zhihui,Liu, Yan,Xu, Teng,et al. Acute hepatitis B infection associated with drug-resistant hepatitis B virus[J]. JOURNAL OF CLINICAL VIROLOGY,2010,48(4):270-274.
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