IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Acute hepatitis B infection associated with drug-resistant hepatitis B virus
Xu, Zhihui1; Liu, Yan1; Xu, Teng2; Chen, Li1; Si, Lanlan1; Wang, Yao1; Ren, Xiaoqiang1; Zhong, Yanwei1; Zhao, Jingmin3; Xu, Dongping1
关键词Hepatitis B virus Acute hepatitis B Drug resistance Variation Nucleoside and nucleotide analogs
刊名JOURNAL OF CLINICAL VIROLOGY
2010-08-01
DOI10.1016/j.jcv.2010.05.010
48期:4页:270-274
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]REVERSE-TRANSCRIPTASE ; LAMIVUDINE ; THERAPY ; HBV ; MUTATION ; RECOMMENDATIONS ; SUSCEPTIBILITY ; EVOLUTION ; VARIANTS ; ADEFOVIR
英文摘要

Background: Pre-existing antiviral-resistant hepatitis B virus (HBV) has been associated with primary non-response to lamivudine treatment in patients with chronic hepatitis B, but little is known of the capacity for resistant HBV to cause primary infection.

Objective: The study was to investigate if Beijing patients with acute hepatitis B (AHB) are infected with drug-resistant HBV.

Study design: Sera were collected from 201 NA-untreated patients with AHB. Direct polymerase chain reaction (PCR) sequencing was used to screen HBV reverse-transcriptase (RT) domain and clonal sequencing were performed for all resistance-positive samples.

Results: Direct PCR sequencing showed that 14 samples (7.0%) were positive for drug-resistant HBV variants, comprised of 11 with the lamivudine-resistant pattern rtM204I and/or rtM204V in the presence and absence of compensatory mutations rtL80I, rtV173L, and rtL180M; two with the adefovir-resistant pattern rtA181V; and one with the entecavir-resistant pattern rtL180M + rtS202G + rtM204V. Concomitance of resistance variants with wild-type HBV was observed in samples from 13 patients. Clonal sequencing verified direct sequencing results. Furthermore, variants associated with resistance to adefovir or entecavir were found in 3 samples.

Conclusions: Drug-resistant HBV strains, including those not resistant to lamivudine, are transmissible and can cause acute hepatitis B in China. (C) 2010 Elsevier B. V. All rights reserved.

语种英语
WOS记录号WOS:000279898100009
项目编号7091006 ; 2007CB512803 ; 2008ZX10002-005-6 ; 2009ZX10004-314
资助机构Beijing Natural Science Foundation ; National Key Basic Research Developing Project ; National 11th Five-Year Special Grand Project for Infectious Diseases
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63846
专题北京大学公共卫生学院
作者单位1.Beijing 302 Hosp, Dept Pathol, Beijing 100039, Peoples R China
2.Beijing 302 Hosp, Inst Infect Dis, Viral Hepatitis Res Lab, Beijing 100039, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, Zhihui,Liu, Yan,Xu, Teng,et al. Acute hepatitis B infection associated with drug-resistant hepatitis B virus[J]. JOURNAL OF CLINICAL VIROLOGY,2010,48(4):270-274.
APA Xu, Zhihui.,Liu, Yan.,Xu, Teng.,Chen, Li.,Si, Lanlan.,...&Xu, Dongping.(2010).Acute hepatitis B infection associated with drug-resistant hepatitis B virus.JOURNAL OF CLINICAL VIROLOGY,48(4),270-274.
MLA Xu, Zhihui,et al."Acute hepatitis B infection associated with drug-resistant hepatitis B virus".JOURNAL OF CLINICAL VIROLOGY 48.4(2010):270-274.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Zhihui]的文章
[Liu, Yan]的文章
[Xu, Teng]的文章
百度学术
百度学术中相似的文章
[Xu, Zhihui]的文章
[Liu, Yan]的文章
[Xu, Teng]的文章
必应学术
必应学术中相似的文章
[Xu, Zhihui]的文章
[Liu, Yan]的文章
[Xu, Teng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。