学科主题临床医学
The design and protocol of acupuncture for migraine prophylaxis: A multicenter randomized controlled trial
Zhang, Yan1; Wang, Linpeng1; Liu, Huilin1; Li, Nan; Li, Jingdao1; Yi, Jinghong1
刊名TRIALS
2009-04-24
DOI10.1186/1745-6215-10-25
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]PREVENTIVE TREATMENT ; PREVALENCE ; HEADACHE ; POPULATION ; MECHANISMS ; PLACEBO ; SOCIETY
英文摘要

Background: Many studies have already reported encouraging results in the prophylactic therapy of migraine by acupuncture, but there seems to be a lack of high quality randomized controlled trials from China. We design and perform a randomized controlled clinical trial to evaluate the efficacy of acupuncture compared with flunarizine in the prophylactic therapy of patients with migraine without aura in China.

Methods: This trial is a multicenter, prospective, randomized controlled clinical trial. The 140 migraine patients are randomly allocated to two different groups. The acupuncture groups (n = 70) is treated with acupuncture and placebo medicine; while the control group (n = 70) is treated with sham acupuncture and medicine (Flunarizine). Both Flunarizine and placebo are taken 10 mg once per night for the first 2 weeks and then 5 mg once per night for the next 2 weeks. Patients in both groups receive 12 sessions of verum/sham acupuncture in 4 weeks.

Discussion: The study design and the long term clinical practice of acupuncturists guarantee a high external validity for the results. The results of our trial will be helpful to supply the evidence on the efficacy of acupuncture for migraine prophylaxis in China.

Trial Registration: The trial is registered at Controlled Clinical Trials: ISRCTN49839714.

语种英语
WOS记录号WOS:000266531900001
资助机构Beijing Administration of Traditional Chinese Medicine ; Capital Medical Development Research Fund (China)
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63847
专题北京大学第三临床医学院_临床流行病学研究中心
作者单位1.Capital Med Univ, Beijing Tradit Chinese Med Hosp, Beijing, Peoples R China
2.Peking Univ, Res Ctr Clin Epidemiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yan,Wang, Linpeng,Liu, Huilin,et al. The design and protocol of acupuncture for migraine prophylaxis: A multicenter randomized controlled trial[J]. TRIALS,2009,10.
APA Zhang, Yan,Wang, Linpeng,Liu, Huilin,Li, Nan,Li, Jingdao,&Yi, Jinghong.(2009).The design and protocol of acupuncture for migraine prophylaxis: A multicenter randomized controlled trial.TRIALS,10.
MLA Zhang, Yan,et al."The design and protocol of acupuncture for migraine prophylaxis: A multicenter randomized controlled trial".TRIALS 10(2009).
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