|Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes|
|Zhu, Cui-Feng1,2; Peng, Hong-Bing1; Liu, Gui-Qin3; Zhang, Fan2; Li, Yong1|
|关键词||Oligopeptides Type 2 diabetes Apoptosis Rat Salmon|
|WOS标题词||Science & Technology|
|类目[WOS]||Nutrition & Dietetics|
|研究领域[WOS]||Nutrition & Dietetics|
|关键词[WOS]||INSULIN-RESISTANCE ; GLUCOSE-TOLERANCE ; MELLITUS ; IMPACT ; DEATH ; MICE ; FAS|
Objective: This study aimed at investigating whether treatment with oligopeptides from marine salmon skin (OMSS) could modulate type 2 diabetes mellitus (T2DM)-related hyperglycemia and beta-cell apoptosis in rats induced by high fit diet and low doses of streptozotocin and its therapeutic mechanisms.
Methods: Groups of T2DM rats were treated with OMSS or bovine serum albumin (3.0 g/kg/d) for 4 wk and their blood samples, together with those of normal control rats, were collected before and 4 wk after treatment. The levels of fasting blood glucose (FBG) and insulin, serum superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH), tumor necrosis factor-alpha (TNF alpha), and interferon-gamma (IFN gamma) in rats were determined. The islet cell apoptosis and Fast FasL expression were detected by TUNEL and immunohistochemistry.
Results: In comparison with control rats, higher levels of FBG and frequency of apoptotic islet cells were detected in the bovine serum albumin group of diabetic rats, accompanied by higher levels of Fas expression in the pancreatic islets, serum TNF alpha, IFN gamma, and MDA, but lower levels of SOD and GSH. However, the levels of FBG and frequency of apoptotic islet cells were significantly reduced in OMSS-treated rats. Lower levels of Fas expression were observed in the pancreatic islets of OMSS-treated rats. Significantly reduced levels of serum TNF alpha, IFN gamma, and MDA, but increased levels of SOD and GSH, were detected in, OMSS-treated rats.
Conclusions: Treatment with OMSS significantly reduced FBG in diabetic rats. This antidiabetic activity may be mediated by down-regulating T2DM-related oxidative stress and inflammation, protecting the pancreatic beta-cells from apoptosis. (C) 2010 Elsevier Inc. All rights reserved.
|项目编号||2006BAD27B01 ; 20080214142|
|资助机构||National Key Technologies R& ; D Program of China ; Science & ; Technology Committee of Futian District State, Shenzhen City, Guangdong Province of China|
|作者单位||1.Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China|
2.Shenzhen Tradit Chinese Med Hosp Futian Dist, Shenzhen, Peoples R China
3.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100871, Peoples R China
|Zhu, Cui-Feng,Peng, Hong-Bing,Liu, Gui-Qin,et al. Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes[J]. NUTRITION,2010,26(10):1014-1020.|
|APA||Zhu, Cui-Feng,Peng, Hong-Bing,Liu, Gui-Qin,Zhang, Fan,&Li, Yong.(2010).Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes.NUTRITION,26(10),1014-1020.|
|MLA||Zhu, Cui-Feng,et al."Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes".NUTRITION 26.10(2010):1014-1020.|