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学科主题: 临床医学
题名:
Synthesis and biodistribution of Tc-99m-peptides conjugated adenine as tumor imaging agents
作者: Zhao, Y. L.; Zhang, C. L.; Qi, C. M.; Feng, S. J.; You, G. R.; Fu, Z. L.; Guo, F. G.; Wang, R. F.
刊名: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
发表日期: 2007-07-01
DOI: 10.1007/s10967-007-0702-3
卷: 273, 期:1, 页:9-13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
研究领域[WOS]: Chemistry ; Nuclear Science & Technology
关键词[WOS]: RADIOLABELED PEPTIDES ; RADIOPHARMACEUTICALS ; LIGANDS
英文摘要:

Two peptide ligands conjugated adenine, [9-N-(tritylmercapto acetyl diglycyl aminoethyl) adenine, Tr-MAG(2)-Ade] and [9-N-(tritylinercapto acetyl triglycyl aminoethyl) adenine, Tr-MAG(3)-Ade], are synthesized and labeled with Tc-99m by directly labeling method. The stability of Tc-99m-MAG(2)-adenine and Tc-99m-MAG(3)-adenine in vitro is measured. The uptake radios of tumor to muscle at 3h post-injection are 5.70 and 4.92, respectively. The biodistribution and scintigraphic imaging studies show that the two complexes have high localization in tumor and high contrasted tumor images can be obtained, which suggest their potential utility as tumor imaging agents. But the high radioactivity of abdomen could prevent the tumor imaging in this area.

语种: 英语
WOS记录号: WOS:000247427400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63858
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Peking Univ, Dept Nucl Med, Beijing 100034, Peoples R China
2.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China

Recommended Citation:
Zhao, Y. L.,Zhang, C. L.,Qi, C. M.,et al. Synthesis and biodistribution of Tc-99m-peptides conjugated adenine as tumor imaging agents[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2007,273(1):9-13.
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