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学科主题临床医学
Synthesis and biodistribution of Tc-99m-peptides conjugated adenine as tumor imaging agents
Zhao, Y. L.; Zhang, C. L.; Qi, C. M.; Feng, S. J.; You, G. R.; Fu, Z. L.; Guo, F. G.; Wang, R. F.
刊名JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
2007-07-01
DOI10.1007/s10967-007-0702-3
273期:1页:9-13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
研究领域[WOS]Chemistry ; Nuclear Science & Technology
关键词[WOS]RADIOLABELED PEPTIDES ; RADIOPHARMACEUTICALS ; LIGANDS
英文摘要

Two peptide ligands conjugated adenine, [9-N-(tritylmercapto acetyl diglycyl aminoethyl) adenine, Tr-MAG(2)-Ade] and [9-N-(tritylinercapto acetyl triglycyl aminoethyl) adenine, Tr-MAG(3)-Ade], are synthesized and labeled with Tc-99m by directly labeling method. The stability of Tc-99m-MAG(2)-adenine and Tc-99m-MAG(3)-adenine in vitro is measured. The uptake radios of tumor to muscle at 3h post-injection are 5.70 and 4.92, respectively. The biodistribution and scintigraphic imaging studies show that the two complexes have high localization in tumor and high contrasted tumor images can be obtained, which suggest their potential utility as tumor imaging agents. But the high radioactivity of abdomen could prevent the tumor imaging in this area.

语种英语
WOS记录号WOS:000247427400002
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63858
专题北京大学第一临床医学院_核医学科
作者单位1.Peking Univ, Dept Nucl Med, Beijing 100034, Peoples R China
2.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Y. L.,Zhang, C. L.,Qi, C. M.,et al. Synthesis and biodistribution of Tc-99m-peptides conjugated adenine as tumor imaging agents[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2007,273(1):9-13.
APA Zhao, Y. L..,Zhang, C. L..,Qi, C. M..,Feng, S. J..,You, G. R..,...&Wang, R. F..(2007).Synthesis and biodistribution of Tc-99m-peptides conjugated adenine as tumor imaging agents.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,273(1),9-13.
MLA Zhao, Y. L.,et al."Synthesis and biodistribution of Tc-99m-peptides conjugated adenine as tumor imaging agents".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 273.1(2007):9-13.
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