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Quantitative determination of Aconitum alkaloids in blood and urine samples by high-performance liquid chromatography
Wang, ZH; Guo, D; He, Y; Hu, CH; Zhang, JZ
关键词high-performance liquid chromatography solid phase extraction quantitative determination Aconitum alkaloids
刊名PHYTOCHEMICAL ANALYSIS
2004
DOI10.1002/pca.736
15期:1页:16-20
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Plant Sciences ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences ; Chemistry
关键词[WOS]ROOTS ; SERUM
英文摘要

An HPLC method has been developed for the simultaneous determination of the toxic Aconitum alkaloids, aconitine, mesaconitine and hypaconitine in blood and urine samples. The samples were initially subjected to solid phase extraction using Oasis(R) MCX cartridges, and the alkaloids were separated on an XTerra(TM) RP18, column, gradient-elluted with acetonitrille: ammonium hydrogen carbonate buffer. Calibration curves were linear in the range 2.75-550 ng for aconitine and hypaconitine, and 3-600 ng for mesaconitine: the limit of detection was 0.1 ng (signal-to-noise ratio of 3) for each alkaloid. The described analysis proved to be sensitive, rapid and economical, and will be applied in the identification and determination of these alkaloids in forensic and therapeutic drug monitoring. Copyright (C) 2004 John Wiley Sons, Ltd.

语种英语
WOS记录号WOS:000188762700003
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63862
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Publ Secur Minist, Forens Sci Inst, Beijing 100038, Peoples R China
推荐引用方式
GB/T 7714
Wang, ZH,Guo, D,He, Y,et al. Quantitative determination of Aconitum alkaloids in blood and urine samples by high-performance liquid chromatography[J]. PHYTOCHEMICAL ANALYSIS,2004,15(1):16-20.
APA Wang, ZH,Guo, D,He, Y,Hu, CH,&Zhang, JZ.(2004).Quantitative determination of Aconitum alkaloids in blood and urine samples by high-performance liquid chromatography.PHYTOCHEMICAL ANALYSIS,15(1),16-20.
MLA Wang, ZH,et al."Quantitative determination of Aconitum alkaloids in blood and urine samples by high-performance liquid chromatography".PHYTOCHEMICAL ANALYSIS 15.1(2004):16-20.
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