北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 泌尿外科  > 期刊论文
学科主题: 临床医学
题名:
Targeting of interleukin-10 is superior to cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G(1) for the prevention of chronic allograft deterioration in organ transplantation
作者: Xu, Tao2,3; Haering, Cristina1; Lau, Chi-Keung2; Obed, Aiman1; Ma, Jian1; Doenecke, Axel1; Scherer, Marcus N.1; Schnitzbauer, Andreas A.1; Fan, Sheung-Tat2; Schlitt, Hans J.1; Tsui, Tung-Yu1
关键词: adeno-associated viral vector ; chronic rejection ; gene therapy ; interleukin-10 ; transplant arteriosclerosis
刊名: JOURNAL OF GENE MEDICINE
发表日期: 2008-12-01
DOI: 10.1002/jgm.1250
卷: 10, 期:12, 页:1315-1323
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]: GENE-TRANSFER ; HEME OXYGENASE-1 ; INDOLEAMINE 2,3-DIOXYGENASE ; TRYPTOPHAN CATABOLISM ; NITRIC-OXIDE ; SURVIVAL ; VIRUS ; REJECTION ; CTLA4IG ; LIVER
英文摘要:

Background Genetic manipulation of the allograft is an attractive approach to prevent the graft against chronic deterioration through stable expression of immunomodulatory or protective genes. However, the best strategy for prevention of chronic allograft deterioration remains unclear.

Methods The efficacies of adeno-associated viral vector-mediated stable expression of indoleamine 2,3-dioxygenase (IDO), cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G, (CTLA4Ig) or interleukin-10 (IL-10) in the prevention of chronic allograft deterioration were compared in a rat heart transplantation model.

Results Transduction of grafts with IL-10 significantly prolonged allograft survival, whereas transduction of grafts with IDO did not improve graft survival compared to controls. Analysis of long-term survived heart allografts showed that both CTLA4Ig and IL-10 could significantly reduced the T cells and macrophage infiltration. However, stable expression of CTLA4Ig failed to prevent the development of transplant arteriosclerosis. By contrast, IL-10 suppressed the development of transplant arteriosclerosis effectively. The suppressive effects of IL-10 in preventing the development of chronic allograft deterioration were associated with lower transcript levels of transforming tumor growth factor beta 1 and macrophage migration inhibitory factor in the graft. In addition, higher transcript levels of heme oxygenase-1 were found in IL-10-transduced allograft.

Conclusions Targeting on IL-10 is superior to CTLA4Ig or IDO for the treatment of chronic allograft deterioration. Copyright (C) 2008 John Wiley & Sons, Ltd.

语种: 英语
项目资助者: CRCG program of The University of Hong Kong ; Faculty of Medicine, University of Regensburg.
WOS记录号: WOS:000262004100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63867
Appears in Collections:北京大学第二临床医学院_泌尿外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Urol, Peoples Hosp, Beijing, Peoples R China
2.Univ Regensburg, Med Ctr, Dept Surg, D-93053 Regensburg, Germany
3.Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Xu, Tao,Haering, Cristina,Lau, Chi-Keung,et al. Targeting of interleukin-10 is superior to cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G(1) for the prevention of chronic allograft deterioration in organ transplantation[J]. JOURNAL OF GENE MEDICINE,2008,10(12):1315-1323.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, Tao]'s Articles
[Haering, Cristina]'s Articles
[Lau, Chi-Keung]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, Tao]‘s Articles
[Haering, Cristina]‘s Articles
[Lau, Chi-Keung]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace