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学科主题临床医学
Targeting of interleukin-10 is superior to cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G(1) for the prevention of chronic allograft deterioration in organ transplantation
Xu, Tao2,3; Haering, Cristina1; Lau, Chi-Keung2; Obed, Aiman1; Ma, Jian1; Doenecke, Axel1; Scherer, Marcus N.1; Schnitzbauer, Andreas A.1; Fan, Sheung-Tat2; Schlitt, Hans J.1; Tsui, Tung-Yu1
关键词adeno-associated viral vector chronic rejection gene therapy interleukin-10 transplant arteriosclerosis
刊名JOURNAL OF GENE MEDICINE
2008-12-01
DOI10.1002/jgm.1250
10期:12页:1315-1323
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
资助者CRCG program of The University of Hong Kong ; Faculty of Medicine, University of Regensburg. ; CRCG program of The University of Hong Kong ; Faculty of Medicine, University of Regensburg.
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]GENE-TRANSFER ; HEME OXYGENASE-1 ; INDOLEAMINE 2,3-DIOXYGENASE ; TRYPTOPHAN CATABOLISM ; NITRIC-OXIDE ; SURVIVAL ; VIRUS ; REJECTION ; CTLA4IG ; LIVER
英文摘要

Background Genetic manipulation of the allograft is an attractive approach to prevent the graft against chronic deterioration through stable expression of immunomodulatory or protective genes. However, the best strategy for prevention of chronic allograft deterioration remains unclear.

Methods The efficacies of adeno-associated viral vector-mediated stable expression of indoleamine 2,3-dioxygenase (IDO), cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G, (CTLA4Ig) or interleukin-10 (IL-10) in the prevention of chronic allograft deterioration were compared in a rat heart transplantation model.

Results Transduction of grafts with IL-10 significantly prolonged allograft survival, whereas transduction of grafts with IDO did not improve graft survival compared to controls. Analysis of long-term survived heart allografts showed that both CTLA4Ig and IL-10 could significantly reduced the T cells and macrophage infiltration. However, stable expression of CTLA4Ig failed to prevent the development of transplant arteriosclerosis. By contrast, IL-10 suppressed the development of transplant arteriosclerosis effectively. The suppressive effects of IL-10 in preventing the development of chronic allograft deterioration were associated with lower transcript levels of transforming tumor growth factor beta 1 and macrophage migration inhibitory factor in the graft. In addition, higher transcript levels of heme oxygenase-1 were found in IL-10-transduced allograft.

Conclusions Targeting on IL-10 is superior to CTLA4Ig or IDO for the treatment of chronic allograft deterioration. Copyright (C) 2008 John Wiley & Sons, Ltd.

语种英语
资助者CRCG program of The University of Hong Kong ; Faculty of Medicine, University of Regensburg. ; CRCG program of The University of Hong Kong ; Faculty of Medicine, University of Regensburg.
WOS记录号WOS:000262004100005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63867
专题北京大学第二临床医学院_泌尿外科
作者单位1.Peking Univ, Dept Urol, Peoples Hosp, Beijing, Peoples R China
2.Univ Regensburg, Med Ctr, Dept Surg, D-93053 Regensburg, Germany
3.Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Xu, Tao,Haering, Cristina,Lau, Chi-Keung,et al. Targeting of interleukin-10 is superior to cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G(1) for the prevention of chronic allograft deterioration in organ transplantation[J]. JOURNAL OF GENE MEDICINE,2008,10(12):1315-1323.
APA Xu, Tao.,Haering, Cristina.,Lau, Chi-Keung.,Obed, Aiman.,Ma, Jian.,...&Tsui, Tung-Yu.(2008).Targeting of interleukin-10 is superior to cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G(1) for the prevention of chronic allograft deterioration in organ transplantation.JOURNAL OF GENE MEDICINE,10(12),1315-1323.
MLA Xu, Tao,et al."Targeting of interleukin-10 is superior to cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G(1) for the prevention of chronic allograft deterioration in organ transplantation".JOURNAL OF GENE MEDICINE 10.12(2008):1315-1323.
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