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学科主题: 基础医学
题名:
Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis
作者: Chen, Ke1; Liu, Jing1; Heck, Susanne; Chasis, Joel A.2; An, Xiuli1,3; Mohandas, Narla1
关键词: CD44 ; CD71 ; erythroblast differentiation ; cell adhesion ; erythrocyte
刊名: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
发表日期: 2009-10-13
DOI: 10.1073/pnas.0909296106
卷: 106, 期:41, 页:17413-17418
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RED-CELL MEMBRANE ; RETICULOCYTE MATURATION ; ASYNCHRONOUS SYNTHESIS ; TRANSFERRIN RECEPTOR ; UNEQUAL SYNTHESIS ; ALPHA-SPECTRIN ; BETA-SPECTRIN ; BLOOD-CELLS ; ERYTHROBLASTS ; SKELETON
英文摘要:

Erythropoiesis is the process by which nucleated erythroid progenitors proliferate and differentiate to generate, every second, millions of nonnucleated red cells with their unique discoid shape and membrane material properties. Here we examined the time course of appearance of individual membrane protein components during murine erythropoiesis to throw new light on our understanding of the evolution of the unique features of the red cell membrane. We found that the accumulation of all of the major transmembrane and all skeletal proteins of the mature red blood cell, except actin, accrued progressively during terminal erythroid differentiation. At the same time, and in marked contrast, accumulation of various adhesion molecules decreased. In particular, the adhesion molecule, CD44 exhibited a progressive and dramatic decrease from proerythroblast to reticulocyte; this enabled us to devise a new strategy for distinguishing unambiguously between erythroblasts at successive developmental stages. These findings provide unique insights into the genesis of red cell membrane function during erythroblast differentiation and also offer a means of defining stage-specific defects in erythroid maturation in inherited and acquired red cell disorders and in bone marrow failure syndromes.

语种: 英语
WOS记录号: WOS:000270754400036
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63879
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.New York Blood Ctr, Red Cell Physiol Lab, New York, NY 10065 USA
2.Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Ke,Liu, Jing,Heck, Susanne,et al. Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(41):17413-17418.
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