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学科主题: 基础医学
题名:
Serotype and VP1 gene sequence of a foot-and-mouth disease virus from Hong Kong (2002)
作者: Feng, Q; Chen, X; Ma, O; Liu, YY; Ding, MX; Collins, RA; Ko, LS; Xing, J; Lau, LT; Yu, ACH; Chen, JG
关键词: foot-and-mouth disease ; VP1 protein ; serotype ; Hong Kong
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2003-03-21
DOI: 10.1016/S0006-291X(03)00250-X
卷: 302, 期:4, 页:715-721
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ACID
英文摘要:

The nucleotide sequence of the VP1 coding region of foot-and-mouth disease virus (FMDV) strain HKN/2002, isolated from a disease outbreak occurring in Hong Kong in February 2002, was determined and compared with the sequences of other FMDVs. The VP1 coding region was 639 nucleotides in length and encoded a protein of 213 amino acid residues. Comparison of the VP1 nucleotide sequence with those of other isolates indicated that HKN/2002 belonged to serotype O. A VPI-based sequence similarity tree of several South-east Asian FMDV-0 isolates showed that HKN/2002 was most closely related to FMDV isolates found in Hong Kong from 1991 to 1999 and Taiwan in 1997. Comparison of the amino acid sequence of the major immunogenic region of HKN/2002 with that of the serotype 0 vaccine strain, O1/Manisa/Turkey/69, reveals significant similarity, indicating that current serotype 0 vaccines may offer some degree of protection against HKN/2002. (C) 2003 Elsevier Science (USA). All rights reserved.

语种: 英语
WOS记录号: WOS:000181881300013
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63882
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China
3.Hong Kong DNA Chips Ltd, Kowloon, Hong Kong, Peoples R China
4.Peking Univ, Coll Life Sci, Dept Cell Biol & Genet, Beijing 100871, Peoples R China

Recommended Citation:
Feng, Q,Chen, X,Ma, O,et al. Serotype and VP1 gene sequence of a foot-and-mouth disease virus from Hong Kong (2002)[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2003,302(4):715-721.
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