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学科主题: 临床医学
题名:
Simvastatin Reduces Expression and Activity of Lipoprotein-associated Phospholipase A(2) in the Aorta of Hypercholesterolaemic Atherosclerotic Rabbits
作者: Qiao, Z.; Ren, J.; Chen, H.
关键词: SIMVASTATIN ; ATHEROSCLEROSIS ; ATHEROSCLEROTIC PLAQUE ; LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A(2)
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2009-07-01
卷: 37, 期:4, 页:1029-1037
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: PLATELET-ACTIVATING-FACTOR ; LOW-DENSITY-LIPOPROTEIN ; FACTOR ACETYLHYDROLASE ; CORONARY ATHEROSCLEROSIS ; LYSOPHOSPHATIDYLCHOLINE ; STATINS ; PROTEIN ; EPIDEMIOLOGY ; INFLAMMATION ; MACROPHAGES
英文摘要:

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) contributes to atherosclerotic plaque instability and subsequent sudden coronary death. Statins are associated with decreased stroke risk and may improve stability of atherosclerotic plaques. The present study investigated the effect of simvastatin on expression of Lp-PLA(2) levels in atherosclerotic plaques and on Lp-PLA(2) activity in atherosclerotic aortas. Rabbits were a fed chow (control group) or a high-cholesterol diet (atherosclerosis group) for 12 weeks. An additional group on the high-cholesterol diet received simvastatin (5 mg/kg per day) for the last 4 weeks (simvastatin group). Lp-PLA(2) activity in plasma and atherosclerotic aortas was significantly higher in the atherosclerosis group than in the control group and, consistent with this, abundant Lp-PLA(2) protein was detected in plaques in the atherosclerosis group. Simvastatin significantly reduced Lp-PLA(2) activity in plasma and aorta tissue, and reduced Lp-PLAZ(2) protein level in atherosclerotic plaques. Whereas there was no significant difference in total atherosclerotic lesion area between simvastatin and atherosclerosis groups, simvastatin significantly reduced macrophage content, lipid retention and the intima/media ratio but increased the content of smooth muscle cells in atherosclerotic lesions. Thus, statin treatment markedly reduced Lp-PLA(2) in both plasma and atherosclerotic plaques. This was associated with attenuation of the local inflammatory response and improved plaque stability.

语种: 英语
WOS记录号: WOS:000271036300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63886
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Qiao, Z.,Ren, J.,Chen, H.. Simvastatin Reduces Expression and Activity of Lipoprotein-associated Phospholipase A(2) in the Aorta of Hypercholesterolaemic Atherosclerotic Rabbits[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2009,37(4):1029-1037.
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