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Simvastatin Reduces Expression and Activity of Lipoprotein-associated Phospholipase A(2) in the Aorta of Hypercholesterolaemic Atherosclerotic Rabbits
Qiao, Z.; Ren, J.; Chen, H.
关键词SIMVASTATIN ATHEROSCLEROSIS ATHEROSCLEROTIC PLAQUE LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A(2)
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2009-07-01
37期:4页:1029-1037
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]PLATELET-ACTIVATING-FACTOR ; LOW-DENSITY-LIPOPROTEIN ; FACTOR ACETYLHYDROLASE ; CORONARY ATHEROSCLEROSIS ; LYSOPHOSPHATIDYLCHOLINE ; STATINS ; PROTEIN ; EPIDEMIOLOGY ; INFLAMMATION ; MACROPHAGES
英文摘要

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) contributes to atherosclerotic plaque instability and subsequent sudden coronary death. Statins are associated with decreased stroke risk and may improve stability of atherosclerotic plaques. The present study investigated the effect of simvastatin on expression of Lp-PLA(2) levels in atherosclerotic plaques and on Lp-PLA(2) activity in atherosclerotic aortas. Rabbits were a fed chow (control group) or a high-cholesterol diet (atherosclerosis group) for 12 weeks. An additional group on the high-cholesterol diet received simvastatin (5 mg/kg per day) for the last 4 weeks (simvastatin group). Lp-PLA(2) activity in plasma and atherosclerotic aortas was significantly higher in the atherosclerosis group than in the control group and, consistent with this, abundant Lp-PLA(2) protein was detected in plaques in the atherosclerosis group. Simvastatin significantly reduced Lp-PLA(2) activity in plasma and aorta tissue, and reduced Lp-PLAZ(2) protein level in atherosclerotic plaques. Whereas there was no significant difference in total atherosclerotic lesion area between simvastatin and atherosclerosis groups, simvastatin significantly reduced macrophage content, lipid retention and the intima/media ratio but increased the content of smooth muscle cells in atherosclerotic lesions. Thus, statin treatment markedly reduced Lp-PLA(2) in both plasma and atherosclerotic plaques. This was associated with attenuation of the local inflammatory response and improved plaque stability.

语种英语
WOS记录号WOS:000271036300007
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63886
专题北京大学第三临床医学院_手术室
北京大学第二临床医学院_心血管内科
作者单位Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Qiao, Z.,Ren, J.,Chen, H.. Simvastatin Reduces Expression and Activity of Lipoprotein-associated Phospholipase A(2) in the Aorta of Hypercholesterolaemic Atherosclerotic Rabbits[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2009,37(4):1029-1037.
APA Qiao, Z.,Ren, J.,&Chen, H..(2009).Simvastatin Reduces Expression and Activity of Lipoprotein-associated Phospholipase A(2) in the Aorta of Hypercholesterolaemic Atherosclerotic Rabbits.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,37(4),1029-1037.
MLA Qiao, Z.,et al."Simvastatin Reduces Expression and Activity of Lipoprotein-associated Phospholipase A(2) in the Aorta of Hypercholesterolaemic Atherosclerotic Rabbits".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 37.4(2009):1029-1037.
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