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MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3
Zhao, Bingtian1; Han, Haibo2; Chen, Jinfeng1; Zhang, Zhiqian2; Li, Shaolei1; Fang, Fang1; Zheng, Qingfeng1; Ma, Yuanyuan1; Zhang, Jianzhi1; Wu, Nan1; Yang, Yue1
关键词MicroRNA Let-7c NSCLC Migration and invasion
刊名CANCER LETTERS
2014
DOI10.1016/j.canlet.2013.08.030
342期:1页:43-51
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]POSTTRANSCRIPTIONAL REGULATION ; RECEPTOR EXPRESSION ; CARCINOMA ; FAMILY ; CHEMOTHERAPY ; METASTASIS ; SUPPRESSOR ; APOPTOSIS ; PATHWAY ; KINASE
英文摘要

MicroRNAs play an important regulatory role in carcinogenesis and cancer metastasis. Different members of let-7 family have been reported to be decreased in human lung tumors. However, the effect of specific let-7 member on metastasis of NSCLC remains undefined. Our current study detected the expression of let-7 members in 94 cases of NSCLC and a significant association was noticed between low levels of let-7c expression and metastasis, venous invasion, advanced TNM stages and poor survival of NSCLC patients. Consistently, ectopic expression of let-7c in relatively highly metastatic cells remarkably suppressed their migration and invasion. Inhibition of let-7c in cells with relatively low metastatic potential promoted their motility and invasion. We then analyzed the potential targets of let-7c and found that ITGB3 and MAP4K3 were directly repressed by let-7c. Upon restoring the expression of ITGB3 and MAP4K3, the effects of let-7c on tumor metastasis were partially reversed, and more importantly, the expression levels of ITGB3 and MAP4K3 were inversely correlated with let-7c in 64 NSCLC tissues. Collectively, our results suggest that let-7c, by degrading ITGB3 and MAP4K3, prevents NSCLC metastasis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000328591100006
项目编号11G2633 ; 5122012 ; 81201964 ; 81071733 ; 2012AA02A502 ; 2010CB529402
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program) ; National Basic Research Program of China (973 Program)
引用统计
被引频次:90[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63887
专题北京大学临床肿瘤学院_胸外科
北京大学临床肿瘤学院_胸部肿瘤外二科
北京大学临床肿瘤学院_603课题组
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 2, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Cell Biol, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Bingtian,Han, Haibo,Chen, Jinfeng,et al. MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3[J]. CANCER LETTERS,2014,342(1):43-51.
APA Zhao, Bingtian.,Han, Haibo.,Chen, Jinfeng.,Zhang, Zhiqian.,Li, Shaolei.,...&Yang, Yue.(2014).MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3.CANCER LETTERS,342(1),43-51.
MLA Zhao, Bingtian,et al."MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3".CANCER LETTERS 342.1(2014):43-51.
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