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学科主题: 临床医学
题名:
Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction
作者: Zhang, Wenduo1; Chu, Songyun2; Ding, Wenhui2; Wang, Fang1
刊名: PLOS ONE
发表日期: 2015-06-19
DOI: 10.1371/journal.pone.0129791
卷: 10, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: LIVER ; OBESITY ; FGF-21 ; ADULTS
英文摘要:

Background

Fibroblast growth factor 21 (FGF21) has been described as a metabolic hormone critical for glucose and lipid metabolism. Previously, high levels of FGF21 were observed in patients with coronary heart disease and non-acute myocardial infarction (non-AMI). In this study, we investigated the changes in FGF21 levels in Chinese patients with AMI.

Methodology/Principal Findings

We used ELISA to measure circulating FGF21 levels in 55 AMI patients and 45 non-AMI control patients on the 1st day after syndrome onset. All patients were followed-up within 30 days. FGF21 levels in AMI patients were significantly higher than those in non-AMI controls (0.25 (0.16-0.34) vs. 0.14 (0.11-0.20) ng/mL, P < 0.001). FGF21 levels reached the maximum within approximately 24 h after the onset of AMI and remained at high for 7 days, and the FGF21 level (OR: 16.93; 95% confidence interval (CI): 2.65-108.05; P = 0.003) was identified as an independent factor associated with the presence of AMI. On the 7th day, FGF21 levels were significantly higher in the patients who subsequently developed re-infarction within 30 days than in the patients who did not develop re-infarction (with vs. without re-infarction: 0.45 (0.22-0.64) vs. 0.21 (0.15-0.29) ng/mL, P = 0.014).

Conclusions/Significance

The level of serum FGF21 is independently associated with the presence of AMI in Chinese patients. High FGF21 levels might be related to the incidence of re-infarction within 30 days after onset.

语种: 英语
WOS记录号: WOS:000356835000060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63891
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.China Minist Hlth, Beijing Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Wenduo,Chu, Songyun,Ding, Wenhui,et al. Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction[J]. PLOS ONE,2015,10(6).
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