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Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction
Zhang, Wenduo1; Chu, Songyun2; Ding, Wenhui2; Wang, Fang1
刊名PLOS ONE
2015-06-19
DOI10.1371/journal.pone.0129791
10期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]LIVER ; OBESITY ; FGF-21 ; ADULTS
英文摘要

Background

Fibroblast growth factor 21 (FGF21) has been described as a metabolic hormone critical for glucose and lipid metabolism. Previously, high levels of FGF21 were observed in patients with coronary heart disease and non-acute myocardial infarction (non-AMI). In this study, we investigated the changes in FGF21 levels in Chinese patients with AMI.

Methodology/Principal Findings

We used ELISA to measure circulating FGF21 levels in 55 AMI patients and 45 non-AMI control patients on the 1st day after syndrome onset. All patients were followed-up within 30 days. FGF21 levels in AMI patients were significantly higher than those in non-AMI controls (0.25 (0.16-0.34) vs. 0.14 (0.11-0.20) ng/mL, P < 0.001). FGF21 levels reached the maximum within approximately 24 h after the onset of AMI and remained at high for 7 days, and the FGF21 level (OR: 16.93; 95% confidence interval (CI): 2.65-108.05; P = 0.003) was identified as an independent factor associated with the presence of AMI. On the 7th day, FGF21 levels were significantly higher in the patients who subsequently developed re-infarction within 30 days than in the patients who did not develop re-infarction (with vs. without re-infarction: 0.45 (0.22-0.64) vs. 0.21 (0.15-0.29) ng/mL, P = 0.014).

Conclusions/Significance

The level of serum FGF21 is independently associated with the presence of AMI in Chinese patients. High FGF21 levels might be related to the incidence of re-infarction within 30 days after onset.

语种英语
WOS记录号WOS:000356835000060
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63891
专题北京大学第一临床医学院_心血管内科
作者单位1.China Minist Hlth, Beijing Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Wenduo,Chu, Songyun,Ding, Wenhui,et al. Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction[J]. PLOS ONE,2015,10(6).
APA Zhang, Wenduo,Chu, Songyun,Ding, Wenhui,&Wang, Fang.(2015).Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction.PLOS ONE,10(6).
MLA Zhang, Wenduo,et al."Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction".PLOS ONE 10.6(2015).
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