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学科主题临床医学
Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL
Zhang, Yue-miao1,2; Cheng, Fa-juan1,2,3; Zhou, Xu-jie1,2; Qi, Yuan-yuan1,2; Hou, Ping1,2; Zhao, Ming-hui1,2; Zhang, Hong1,2
刊名JOURNAL OF IMMUNOLOGY RESEARCH
2015
DOI10.1155/2015/153132
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]GENOME-WIDE ASSOCIATION ; RHEUMATOID-ARTHRITIS ; ERYTHEMATOSUS ; EXPRESSION ; POPULATION ; DISEASE ; CHINESE ; IDENTIFICATION ; AUTOPHAGY ; NETWORKS
英文摘要

Objectives. Numerous loci were identified to perturb gene expression in trans. As elevated ATG5 expression was observed in systemic lupus erythematosus (SLE), the study was conducted to analyze the genome-wide genetic regulatory mechanisms associated with ATG5 expression in a Chinese population with lupus nephritis (LN). Methods. The online expression quantitative trait loci database was searched for trans-expression single nucleotide polymorphisms (trans-eSNPs) of ATG5. Tagging trans-eSNPs were genotyped by a custom-made genotyping chip in 280 patients and 199 controls. For positive findings, clinical information and bioinformation analyses were performed. Results. Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1). Correlations between the trans-eSNPs and ATG5 expression and different expression levels of ATG5 in SLE patients and controls were validated, and their regulatory effects were annotated. However, no significant associations were observed between different genotypes of trans-eSNPs and severity or outcome of the patients. Conclusion. Using the new systemic genetics approach, we identified 10 loci associated with susceptibility to LN potentially, which may be complementary to future pathway based genetic studies.

语种英语
WOS记录号WOS:000363175200001
项目编号81200524 ; 20120001120008 ; 7152148 ; 2012CB517700 ; 20121000110 ; 81021004
资助机构National Natural Science Foundation of China ; Foundation of Ministry of Education of China ; Beijing Natural Science Foundation ; Major State Basic Research Development Program of China (973 program) ; Research Fund of Beijing Municipal Science and Technology for the Outstanding Ph.D. Program ; Natural Science Fund of China to the Innovation Research Group
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63902
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Inst Nephrol, Renal Div,Key Lab Renal Dis,Minist Hlth China, Beijing 100034, Peoples R China
2.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100034, Peoples R China
3.Shandong Univ, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yue-miao,Cheng, Fa-juan,Zhou, Xu-jie,et al. Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2015.
APA Zhang, Yue-miao.,Cheng, Fa-juan.,Zhou, Xu-jie.,Qi, Yuan-yuan.,Hou, Ping.,...&Zhang, Hong.(2015).Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL.JOURNAL OF IMMUNOLOGY RESEARCH.
MLA Zhang, Yue-miao,et al."Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL".JOURNAL OF IMMUNOLOGY RESEARCH (2015).
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