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A Meta-Analysis of Retention in Methadone Maintenance by Dose and Dosing Strategy
Bao, Yan-ping1; Liu, Zhi-min1; Epstein, David H.2; Du, Cun1; Shi, Jie1; Lu, Lin1
关键词Dosing strategy meta-analysis methadone opioid dependence retention
刊名AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
2009
DOI10.1080/00952990802342899
35期:1页:28-33
收录类别SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Substance Abuse
研究领域[WOS]Psychology ; Substance Abuse
关键词[WOS]OPIOID DEPENDENCE ; DOUBLE-BLIND ; RANDOMIZED-TRIAL ; HEROIN-ADDICTS ; DRUG-USERS ; BUPRENORPHINE ; ACETATE ; MANAGEMENT ; RISK
英文摘要

Objective: To estimate, via meta-analysis, the influence of different methadone dose ranges and dosing strategies on retention rates in methadone maintenance treatment (MMT). Methods: A systematic literature search identified 18 randomized controlled trials (RCTs) evaluating methadone dose and retention. Retention was defined as the percentage of patients remaining in treatment at a specified time point. After initial univariate analyses of retention by Pearson chi-squares, we used multilevel logistic regression to calculate summary odds ratios (ORs) and 95% confidence intervals for the effects of methadone dose (above or below 60 mg/day), flexible vs. fixed dosing strategy, and duration of follow-up. Results: The total number of opioid-dependent participants in the 18 studies was 2831, with 1797 in MMT and 1034 receiving alternative mediations or placebo. Each variable significantly predicted retention with the other variables controlled for. Retention was greater with methadone doses 60 than with doses 60 (OR: 1.74, 95% CI: 1.43-2.11). Similarly, retention was greater with flexible-dose strategies than with fixed-dose strategies (OR: 1.72, 95% CI: 1.41-2.11). Conclusions: Higher doses of methadone and individualization of doses are each independently associated with better retention in MMT.

语种英语
WOS记录号WOS:000262508900005
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63905
专题中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.NIDA, Intramural Res Program, Natl Inst Hlth, Baltimore, MD USA
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Bao, Yan-ping,Liu, Zhi-min,Epstein, David H.,et al. A Meta-Analysis of Retention in Methadone Maintenance by Dose and Dosing Strategy[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,2009,35(1):28-33.
APA Bao, Yan-ping,Liu, Zhi-min,Epstein, David H.,Du, Cun,Shi, Jie,&Lu, Lin.(2009).A Meta-Analysis of Retention in Methadone Maintenance by Dose and Dosing Strategy.AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,35(1),28-33.
MLA Bao, Yan-ping,et al."A Meta-Analysis of Retention in Methadone Maintenance by Dose and Dosing Strategy".AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE 35.1(2009):28-33.
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