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Impaired working memory by repeated neonatal MK-801 treatment is ameliorated by galantamine in adult rats
Su, Yun-Ai1,2; Huang, Run-Hu1,2,3; Wang, Xiao-Dong1,2; Li, Ji-Tao1,2; Si, Tian-Mei1,2
关键词Schizophrenia Working memory MK-301 Galantamine
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2014-02-15
DOI10.1016/j.ejohar.2014.01.007
725页:32-39
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ALLOSTERIC POTENTIATING LIGAND ; SCHIZOPHRENIC-PATIENTS ; COGNITIVE FLEXIBILITY ; KYNURENIC ACID ; ACETYLCHOLINE-RECEPTOR ; NICOTINIC AGONIST ; BRAIN-DEVELOPMENT ; NMDA RECEPTORS ; BLOCKADE ; DEFICITS
英文摘要

Early life blockade of the NMDA receptor by using MK-801, a non-competitive NMDA receptor antagonist, induces behavioral changes that mimic several features of schizophrenia. In the current study, we first examined the effects of neonatal MK-801 treatment in male Sprague-Dawley rats on locomotor activity, prepulse inhibition and spatial working memory in adolescence (postnatal day 35, PND35) and adulthood (PND63). Next, we investigated the effects of an acetylcholinesterase inhibitor, galantamine, on working memory deficits induced by MK-801 treatment. Rats were treated with either saline or MK-801 (0.25 mg/kg twice daily) at PND 5-14, and the long-term behavioral effects were investigated. MK-801 treated rats showed moderate working memory impairments in adolescence but a pronounced deficit in adulthood. However, locomotion and prepulse inhibition at two life stages were not affected by this treatment. Systemic administration of galantamine (1 mg/kg) 30 min before each training session significantly improved neonatal MK-801-induced working memory deficits in adulthood. In conclusion, these results suggest that the neonatal MK-801 treatment-induced selective working memory deficit is related to a change in brain cholinergic systems. (C) 2014 Elsevier B.V. All rights reserved

语种英语
WOS记录号WOS:000331140900005
项目编号81171284 ; 30800361 ; 20120001110046
资助机构Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63907
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_药理室
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Shanxi Dayi Hosp, Taiyuan, Shanxi Province, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
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GB/T 7714
Su, Yun-Ai,Huang, Run-Hu,Wang, Xiao-Dong,et al. Impaired working memory by repeated neonatal MK-801 treatment is ameliorated by galantamine in adult rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2014,725:32-39.
APA Su, Yun-Ai,Huang, Run-Hu,Wang, Xiao-Dong,Li, Ji-Tao,&Si, Tian-Mei.(2014).Impaired working memory by repeated neonatal MK-801 treatment is ameliorated by galantamine in adult rats.EUROPEAN JOURNAL OF PHARMACOLOGY,725,32-39.
MLA Su, Yun-Ai,et al."Impaired working memory by repeated neonatal MK-801 treatment is ameliorated by galantamine in adult rats".EUROPEAN JOURNAL OF PHARMACOLOGY 725(2014):32-39.
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