北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Impaired working memory by repeated neonatal MK-801 treatment is ameliorated by galantamine in adult rats
作者: Su, Yun-Ai1,2; Huang, Run-Hu1,2,3; Wang, Xiao-Dong1,2; Li, Ji-Tao1,2; Si, Tian-Mei1,2
关键词: Schizophrenia ; Working memory ; MK-301 ; Galantamine
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2014-02-15
DOI: 10.1016/j.ejohar.2014.01.007
卷: 725, 页:32-39
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ALLOSTERIC POTENTIATING LIGAND ; SCHIZOPHRENIC-PATIENTS ; COGNITIVE FLEXIBILITY ; KYNURENIC ACID ; ACETYLCHOLINE-RECEPTOR ; NICOTINIC AGONIST ; BRAIN-DEVELOPMENT ; NMDA RECEPTORS ; BLOCKADE ; DEFICITS
英文摘要:

Early life blockade of the NMDA receptor by using MK-801, a non-competitive NMDA receptor antagonist, induces behavioral changes that mimic several features of schizophrenia. In the current study, we first examined the effects of neonatal MK-801 treatment in male Sprague-Dawley rats on locomotor activity, prepulse inhibition and spatial working memory in adolescence (postnatal day 35, PND35) and adulthood (PND63). Next, we investigated the effects of an acetylcholinesterase inhibitor, galantamine, on working memory deficits induced by MK-801 treatment. Rats were treated with either saline or MK-801 (0.25 mg/kg twice daily) at PND 5-14, and the long-term behavioral effects were investigated. MK-801 treated rats showed moderate working memory impairments in adolescence but a pronounced deficit in adulthood. However, locomotion and prepulse inhibition at two life stages were not affected by this treatment. Systemic administration of galantamine (1 mg/kg) 30 min before each training session significantly improved neonatal MK-801-induced working memory deficits in adulthood. In conclusion, these results suggest that the neonatal MK-801 treatment-induced selective working memory deficit is related to a change in brain cholinergic systems. (C) 2014 Elsevier B.V. All rights reserved

语种: 英语
所属项目编号: 81171284 ; 30800361 ; 20120001110046
项目资助者: Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000331140900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63907
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Shanxi Dayi Hosp, Taiyuan, Shanxi Province, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Su, Yun-Ai,Huang, Run-Hu,Wang, Xiao-Dong,et al. Impaired working memory by repeated neonatal MK-801 treatment is ameliorated by galantamine in adult rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2014,725:32-39.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Su, Yun-Ai]'s Articles
[Huang, Run-Hu]'s Articles
[Wang, Xiao-Dong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Su, Yun-Ai]‘s Articles
[Huang, Run-Hu]‘s Articles
[Wang, Xiao-Dong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace