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学科主题基础医学
Overexpression of apolipoprotein AV in the liver reduces plasma triglyceride and cholesterol but not HDL in ApoE deficient mice
Huang, W; Bi, N; Zhang, XH; Wang, YN; Chen, BS; Liu, G
关键词adenoviral vector Apolipoprotein AV Apolipoprotein E triglyceride cholesterol hypercholesterolemia high density lipoprotein
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2006-07-21
DOI10.1016/j.bbrc.2006.05.072
346期:1页:14-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]LIPOPROTEIN-LIPASE ; RICH LIPOPROTEINS ; HYDROLYSIS ; HUMANS ; GENE ; A5
英文摘要

It has been shown that adenovirus-mediated overexpression of human ApoAV (hApoAV) in C57BL/6 mice results in decreased plasma triglyceride (TG) and total cholesterol (TC) levels with a major reduction occurring in the HDL fraction. In order to study the effect of ApoAV on hypercholesterolemic mice, an adenoviral vector expressing hApoAV was constructed and injected into ApoE deficient mice. High levels of hApoAV mRNA in the liver and ApoAV proteins in the liver and plasma were detected. The treatment reduced plasma TG levels by 50% and 75%, and TC levels by 45% and 58% at day 3 and 7, respectively, after treatment as compared with a control group treated with Ad-hAP (human alkaline phosphatase). Plasma HDL-C levels remained unaltered, which were different from normolipidemic mice. These findings suggest that ApoAV might serve as a therapeutic agent for hyperlipidemic disorder. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000238549100003
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63908
专题北京大学基础医学院_心血管所
作者单位1.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100083, Peoples R China
3.Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll, Beijing 100005, Peoples R China
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GB/T 7714
Huang, W,Bi, N,Zhang, XH,et al. Overexpression of apolipoprotein AV in the liver reduces plasma triglyceride and cholesterol but not HDL in ApoE deficient mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,346(1):14-18.
APA Huang, W,Bi, N,Zhang, XH,Wang, YN,Chen, BS,&Liu, G.(2006).Overexpression of apolipoprotein AV in the liver reduces plasma triglyceride and cholesterol but not HDL in ApoE deficient mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,346(1),14-18.
MLA Huang, W,et al."Overexpression of apolipoprotein AV in the liver reduces plasma triglyceride and cholesterol but not HDL in ApoE deficient mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 346.1(2006):14-18.
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