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学科主题: 基础医学
题名:
Overexpression of apolipoprotein AV in the liver reduces plasma triglyceride and cholesterol but not HDL in ApoE deficient mice
作者: Huang, W; Bi, N; Zhang, XH; Wang, YN; Chen, BS; Liu, G
关键词: adenoviral vector ; Apolipoprotein AV ; Apolipoprotein E ; triglyceride ; cholesterol ; hypercholesterolemia ; high density lipoprotein
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2006-07-21
DOI: 10.1016/j.bbrc.2006.05.072
卷: 346, 期:1, 页:14-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: LIPOPROTEIN-LIPASE ; RICH LIPOPROTEINS ; HYDROLYSIS ; HUMANS ; GENE ; A5
英文摘要:

It has been shown that adenovirus-mediated overexpression of human ApoAV (hApoAV) in C57BL/6 mice results in decreased plasma triglyceride (TG) and total cholesterol (TC) levels with a major reduction occurring in the HDL fraction. In order to study the effect of ApoAV on hypercholesterolemic mice, an adenoviral vector expressing hApoAV was constructed and injected into ApoE deficient mice. High levels of hApoAV mRNA in the liver and ApoAV proteins in the liver and plasma were detected. The treatment reduced plasma TG levels by 50% and 75%, and TC levels by 45% and 58% at day 3 and 7, respectively, after treatment as compared with a control group treated with Ad-hAP (human alkaline phosphatase). Plasma HDL-C levels remained unaltered, which were different from normolipidemic mice. These findings suggest that ApoAV might serve as a therapeutic agent for hyperlipidemic disorder. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000238549100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63908
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100083, Peoples R China
3.Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll, Beijing 100005, Peoples R China

Recommended Citation:
Huang, W,Bi, N,Zhang, XH,et al. Overexpression of apolipoprotein AV in the liver reduces plasma triglyceride and cholesterol but not HDL in ApoE deficient mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,346(1):14-18.
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