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学科主题: 临床医学
题名:
Electron Beam Melting Fabrication of Porous Ti6Al4V Scaffolds: Cytocompatibility and Osteogenesis
作者: Lv, Jia1; Jia, Zhaojun2; Li, Jing3; Wang, Yanen4; Yang, Jun1; Xiu, Peng1; Zhang, Ke1; Cai, Hong1; Liu, Zhongjun1
刊名: ADVANCED ENGINEERING MATERIALS
发表日期: 2015-09-01
DOI: 10.1002/adem.201400508
卷: 17, 期:9, 页:1391-1398
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Multidisciplinary
研究领域[WOS]: Materials Science
关键词[WOS]: MESENCHYMAL STEM-CELLS ; TITANIUM WEAR DEBRIS ; IN-VIVO ; BIOLOGICAL RESPONSES ; BONE ; DIFFERENTIATION ; OSSEOINTEGRATION ; BIOCOMPATIBILITY ; ATTACHMENT ; BEHAVIOR
英文摘要:

Titanium-based implants possessing adequately low elasticity modulus and customdesigned structures are urgently demanded in recent years for orthopedic applications. Electron beam melting (EBM) provides an opportunity to fabricated porous titanium scaffolds that meet the as-mentioned requirements, and it further allows for improved bone regeneration and increased contact area at implant-tissue interface. As a novel additive manufacturing (AM) technique, EBM could conveniently produce scaffolds with tunable porosity and shapes and complex structures based on the popular "bottom-up" concept. In the present work, EBM-produced Ti6Al4V cylinders designed with either a small pore size (EBMS, 640 mu m) or a large one (EBML, 1200 mu m) were characterized in respect of microstructure, permeability and specific surface area, and their cytocompatibility and osteogenic ability were evaluated subsequently in vitro. Both samples EBMS and EBML could support the attachment and proliferation of hMSCs with minimal inflammatory cytokines secretion. The EBMS scaffolds were relatively more compatible with hMSCs than the EBML and they better sustained osteogenesis probably for their larger specific surface area.

语种: 英语
所属项目编号: Z121100005312005 ; Z141100002814008 ; 51175432
项目资助者: Beijing AKEC Medical Co. Ltd ; Beijing Key Laboratory of Spinal Diseases of Peking University Third Hospital ; Medical Research Center of Peking University Third Hospital ; Project of Scientific and Technical Plan of Beijing ; National Natural Science Foundation of China
WOS记录号: WOS:000362515600019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63912
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
4.Northwestern Polytech Univ, Sch Mech Engn, Xian 710072, Peoples R China

Recommended Citation:
Lv, Jia,Jia, Zhaojun,Li, Jing,et al. Electron Beam Melting Fabrication of Porous Ti6Al4V Scaffolds: Cytocompatibility and Osteogenesis[J]. ADVANCED ENGINEERING MATERIALS,2015,17(9):1391-1398.
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