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学科主题临床医学
Electron Beam Melting Fabrication of Porous Ti6Al4V Scaffolds: Cytocompatibility and Osteogenesis
Lv, Jia1; Jia, Zhaojun2; Li, Jing3; Wang, Yanen4; Yang, Jun1; Xiu, Peng1; Zhang, Ke1; Cai, Hong1; Liu, Zhongjun1
刊名ADVANCED ENGINEERING MATERIALS
2015-09-01
DOI10.1002/adem.201400508
17期:9页:1391-1398
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Multidisciplinary
资助者Beijing AKEC Medical Co. Ltd ; Beijing Key Laboratory of Spinal Diseases of Peking University Third Hospital ; Medical Research Center of Peking University Third Hospital ; Project of Scientific and Technical Plan of Beijing ; National Natural Science Foundation of China ; Beijing AKEC Medical Co. Ltd ; Beijing Key Laboratory of Spinal Diseases of Peking University Third Hospital ; Medical Research Center of Peking University Third Hospital ; Project of Scientific and Technical Plan of Beijing ; National Natural Science Foundation of China
研究领域[WOS]Materials Science
关键词[WOS]MESENCHYMAL STEM-CELLS ; TITANIUM WEAR DEBRIS ; IN-VIVO ; BIOLOGICAL RESPONSES ; BONE ; DIFFERENTIATION ; OSSEOINTEGRATION ; BIOCOMPATIBILITY ; ATTACHMENT ; BEHAVIOR
英文摘要

Titanium-based implants possessing adequately low elasticity modulus and customdesigned structures are urgently demanded in recent years for orthopedic applications. Electron beam melting (EBM) provides an opportunity to fabricated porous titanium scaffolds that meet the as-mentioned requirements, and it further allows for improved bone regeneration and increased contact area at implant-tissue interface. As a novel additive manufacturing (AM) technique, EBM could conveniently produce scaffolds with tunable porosity and shapes and complex structures based on the popular "bottom-up" concept. In the present work, EBM-produced Ti6Al4V cylinders designed with either a small pore size (EBMS, 640 mu m) or a large one (EBML, 1200 mu m) were characterized in respect of microstructure, permeability and specific surface area, and their cytocompatibility and osteogenic ability were evaluated subsequently in vitro. Both samples EBMS and EBML could support the attachment and proliferation of hMSCs with minimal inflammatory cytokines secretion. The EBMS scaffolds were relatively more compatible with hMSCs than the EBML and they better sustained osteogenesis probably for their larger specific surface area.

语种英语
所属项目编号Z121100005312005 ; Z141100002814008 ; 51175432
资助者Beijing AKEC Medical Co. Ltd ; Beijing Key Laboratory of Spinal Diseases of Peking University Third Hospital ; Medical Research Center of Peking University Third Hospital ; Project of Scientific and Technical Plan of Beijing ; National Natural Science Foundation of China ; Beijing AKEC Medical Co. Ltd ; Beijing Key Laboratory of Spinal Diseases of Peking University Third Hospital ; Medical Research Center of Peking University Third Hospital ; Project of Scientific and Technical Plan of Beijing ; National Natural Science Foundation of China
WOS记录号WOS:000362515600019
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63912
专题北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
4.Northwestern Polytech Univ, Sch Mech Engn, Xian 710072, Peoples R China
推荐引用方式
GB/T 7714
Lv, Jia,Jia, Zhaojun,Li, Jing,et al. Electron Beam Melting Fabrication of Porous Ti6Al4V Scaffolds: Cytocompatibility and Osteogenesis[J]. ADVANCED ENGINEERING MATERIALS,2015,17(9):1391-1398.
APA Lv, Jia.,Jia, Zhaojun.,Li, Jing.,Wang, Yanen.,Yang, Jun.,...&Liu, Zhongjun.(2015).Electron Beam Melting Fabrication of Porous Ti6Al4V Scaffolds: Cytocompatibility and Osteogenesis.ADVANCED ENGINEERING MATERIALS,17(9),1391-1398.
MLA Lv, Jia,et al."Electron Beam Melting Fabrication of Porous Ti6Al4V Scaffolds: Cytocompatibility and Osteogenesis".ADVANCED ENGINEERING MATERIALS 17.9(2015):1391-1398.
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