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学科主题: 临床医学
题名:
Oncologic outcomes of primary and post-irradiated early stage rectal cancer: A retrospective cohort study
作者: Du, Chang-Zheng1; Chen, Yong-Chun1; Cai, Yong2; Xue, Wei-Cheng3; Gu, Jin1
关键词: Rectal cancer ; Neoadjuvant radiotherapy ; Total mesorectal excision
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2011-07-21
DOI: 10.3748/wjg.v17.i27.3229
卷: 17, 期:27, 页:3229-3234
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PREOPERATIVE RADIOTHERAPY ; CURATIVE RESECTION ; CHEMORADIATION ; CHEMOTHERAPY ; RECURRENCE ; SURGERY ; CHEMORADIOTHERAPY ; SURVIVAL ; THERAPY ; RADIOCHEMOTHERAPY
英文摘要:

AIM: To evaluate the oncologic outcomes of primary and post-irradiated early stage rectal cancer and the effectiveness of adjuvant chemotherapy for rectal cancer patients.

METHODS: Eighty-four patients with stage I rectal cancer after radical surgery were studied retrospectively and divided into ypstage I group (n = 45) and pstage I group (n = 39), according to their preoperative radiation, and compared by univariate and multivariate analysis.

RESULTS: The median follow-up time of patients was 70 mo. No significant difference was observed in disease progression between the two groups. The 5-year disease-free survival rate was 84.4% and 92.3%, respectively (P = 0.327) and the 5-year overall survival rate was 88.9% and 92.3%, respectively, for the two groups (P = 0.692). The disease progression was not significantly associated with the pretreatment clinical stage in ypstage I group. The 5-year disease progression rate was 10.5% and 19.2%, respectively, for the patients who received adjuvant chemotherapy and for those who rejected chemotherapy in the ypstage I group (P = 0.681).

CONCLUSION: The oncologic outcomes of primary and post-irradiated early stage rectal cancer are similar. Patients with ypstage I rectal cancer may slightly benefit from adjuvant chemotherapy. (C) 2011 Baishideng. All rights reserved.

语种: 英语
WOS记录号: WOS:000293660600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63916
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Colorectal Surg, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Dept Radiotherapy, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Dept Pathol, Beijing 100142, Peoples R China

Recommended Citation:
Du, Chang-Zheng,Chen, Yong-Chun,Cai, Yong,et al. Oncologic outcomes of primary and post-irradiated early stage rectal cancer: A retrospective cohort study[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(27):3229-3234.
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