IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所
学科主题临床医学
Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer
Hou, Ruiping1; Cao, Bangwei2; Chen, Zhongdong; Li, Yong1,4; Ning, Tao4; Li, Chunhui; Xu, Changqing1; Chen, Ziping1,3
关键词CTLA-4 Gastric cancer Haplotype Susceptibility
刊名MOLECULAR BIOLOGY REPORTS
2010
DOI10.1007/s11033-009-9705-1
37期:1页:515-520
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; EXON-1 POLYMORPHISMS ; IRANIAN PATIENTS ; PROMOTER REGION ; CTLA-4 ; POPULATION
英文摘要

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) was widely accepted as a pivotal molecule in downregulating T-cell mediated immune responses. In this study we investigated the polymorphisms which would impact the CTLA-4 gene expression and function to assess the association with the risk of gastric cancer. 205 gastric cancer patients and 262 healthy controls were included in the case-control study. PCR and restriction fragment length polymorphism (RFLP) methods were performed to identify the +49A/G and promoter -1661A/G polymorphisms. The promoter -1772T/C polymorphism was detected by PCR amplification refractory mutation system (ARMS) technique. A significant difference was observed between case and control groups. The frequency of +49A/G polymorphism AG and -1661A/G polymorphism GG genotype were significantly higher in patients than in controls (OR = 2.15, OR = 1.88, respectively). No significant difference was found in the allelic frequency of -1772T/C polymorphism between cases and controls (P = 0.478). By the haplotype analysis, logistic regression showed the frequency of haplotype A (GAT) and D (AGT) in the case group revealed significant difference compared with in control group(OR = 2.00, P < 0.001; OR = 1.62, P = 0.043, respectively). Our findings implied the genetic variations within CTLA-4 gene would be a critical risk factor to the susceptibility of gastric cancer.

语种英语
WOS记录号WOS:000273319000078
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63918
专题北京大学第一临床医学院_临床药理研究所
北京大学临床肿瘤学院_遗传学研究室
作者单位1.Shandong Univ, Coll Med, Shandong Prov Qianfoshan Hosp, Dept Gastroenterol, Jinan 250014, Shandong, Peoples R China
2.Peking Univ, Hosp 1, Inst Clin Pharmacol, Dept Antiinfect, Beijing 100034, Peoples R China
3.Seventh Hosp Zhengzhou, Zhengzhou 450006, Henan Province, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100142, Peoples R China
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GB/T 7714
Hou, Ruiping,Cao, Bangwei,Chen, Zhongdong,et al. Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer[J]. MOLECULAR BIOLOGY REPORTS,2010,37(1):515-520.
APA Hou, Ruiping.,Cao, Bangwei.,Chen, Zhongdong.,Li, Yong.,Ning, Tao.,...&Chen, Ziping.(2010).Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer.MOLECULAR BIOLOGY REPORTS,37(1),515-520.
MLA Hou, Ruiping,et al."Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer".MOLECULAR BIOLOGY REPORTS 37.1(2010):515-520.
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