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学科主题: 临床医学
题名:
Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer
作者: Hou, Ruiping1; Cao, Bangwei2; Chen, Zhongdong; Li, Yong1,4; Ning, Tao4; Li, Chunhui; Xu, Changqing1; Chen, Ziping1,3
关键词: CTLA-4 ; Gastric cancer ; Haplotype ; Susceptibility
刊名: MOLECULAR BIOLOGY REPORTS
发表日期: 2010
DOI: 10.1007/s11033-009-9705-1
卷: 37, 期:1, 页:515-520
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; EXON-1 POLYMORPHISMS ; IRANIAN PATIENTS ; PROMOTER REGION ; CTLA-4 ; POPULATION
英文摘要:

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) was widely accepted as a pivotal molecule in downregulating T-cell mediated immune responses. In this study we investigated the polymorphisms which would impact the CTLA-4 gene expression and function to assess the association with the risk of gastric cancer. 205 gastric cancer patients and 262 healthy controls were included in the case-control study. PCR and restriction fragment length polymorphism (RFLP) methods were performed to identify the +49A/G and promoter -1661A/G polymorphisms. The promoter -1772T/C polymorphism was detected by PCR amplification refractory mutation system (ARMS) technique. A significant difference was observed between case and control groups. The frequency of +49A/G polymorphism AG and -1661A/G polymorphism GG genotype were significantly higher in patients than in controls (OR = 2.15, OR = 1.88, respectively). No significant difference was found in the allelic frequency of -1772T/C polymorphism between cases and controls (P = 0.478). By the haplotype analysis, logistic regression showed the frequency of haplotype A (GAT) and D (AGT) in the case group revealed significant difference compared with in control group(OR = 2.00, P < 0.001; OR = 1.62, P = 0.043, respectively). Our findings implied the genetic variations within CTLA-4 gene would be a critical risk factor to the susceptibility of gastric cancer.

语种: 英语
WOS记录号: WOS:000273319000078
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63918
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.Shandong Univ, Coll Med, Shandong Prov Qianfoshan Hosp, Dept Gastroenterol, Jinan 250014, Shandong, Peoples R China
2.Peking Univ, Hosp 1, Inst Clin Pharmacol, Dept Antiinfect, Beijing 100034, Peoples R China
3.Seventh Hosp Zhengzhou, Zhengzhou 450006, Henan Province, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100142, Peoples R China

Recommended Citation:
Hou, Ruiping,Cao, Bangwei,Chen, Zhongdong,et al. Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer[J]. MOLECULAR BIOLOGY REPORTS,2010,37(1):515-520.
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