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学科主题临床医学
Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients
Ji, Dengbo1; Li, Ming1; Zhan, Tiancheng1; Yao, Yunfeng1; Shen, Jing2; Tian, Huifang2; Zhang, Zhiqian3; Gu, Jin1
刊名CARCINOGENESIS
2013-06-01
DOI10.1093/carcin/bgt056
34期:6页:1265-1272
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]EPITHELIUM-DERIVED FACTOR ; GEL-ELECTROPHORESIS ; PROTEOMIC ANALYSIS ; MASS-SPECTROMETRY ; PROSTATE-CANCER ; BREAST-CANCER ; TUMOR-MARKERS ; ZN-ALPHA-2-GLYCOPROTEIN ; IDENTIFICATION ; PEROXIREDOXIN
英文摘要

This study was designed to develop novel and better reliable serum prognostic biomarkers for colorectal cancer (CRC). A 50 sample set including CRC, adenoma and healthy control sera was used to identify the serum proteins involved in CRC carcinogenesis using serum proteomic approach. Alpha-2-glycoprotein 1, zinc-binding (AZGP1), pigment epithelium derived factor (PEDF) and peroxiredoxin 2 (PRDX2) were selected as good candidates. Two independent cohorts of 868 individuals were enrolled. The expression of selected proteins in serum from cohort 1 (n 534) was quantified with enzyme-linked immunosorbent assays. CRC sera of this cohort (n 405) were assigned to training and test sets, which were used to identify and verify the prognostic markers. The prognostic values of identified proteins were further validated in cohort 2 (n 334) using quantitative reverse transcription PCR and immunohistochemical staining. Our data showed that the elevated AZGP1 and decreased PEDF and PRDX2 expressions in CRC serum and tissues were correlated with liver metastases. In the training set, higher AZGP1 and lower PEDF levels in sera were significantly associated with a poorer overall survival (OS), higher AZGP1 was also associated with a poorer disease-free survival (DFS). This association was verified in the testing set and further validated in patients in cohort 2. Patients with lower PEDF or PRDX2 levels in their CRC tissues had a significantly poorer DFS or OS than patients with high levels of these proteins in cohort 2. Univariate and multivariate analyses indicated that the prognostic performance of serum AZGP1 and PEDF was independent of other clinicopathological factors. We propose that they may serve as prognostic markers and potential therapeutic targets in CRC.

语种英语
WOS记录号WOS:000320271100011
项目编号2008BAI52B03 ; 2012AA02A506 ; 81201965 ; 7132052
资助机构Supporting Program for Science and Technology Research of China ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation ; Beijing Municipal Natural Science Foundation
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63920
专题北京大学深圳医院_中心实验室
北京大学临床肿瘤学院_中心实验室
北京大学临床肿瘤学院_603课题组
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Cent Lab, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Cell Biol, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Ji, Dengbo,Li, Ming,Zhan, Tiancheng,et al. Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients[J]. CARCINOGENESIS,2013,34(6):1265-1272.
APA Ji, Dengbo.,Li, Ming.,Zhan, Tiancheng.,Yao, Yunfeng.,Shen, Jing.,...&Gu, Jin.(2013).Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients.CARCINOGENESIS,34(6),1265-1272.
MLA Ji, Dengbo,et al."Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients".CARCINOGENESIS 34.6(2013):1265-1272.
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