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学科主题: 基础医学
题名:
CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest
作者: Pan, Wen1; Cheng, Yingying1; Zhang, Heyu1,2; Liu, Baocai1; Mo, Xiaoning1; Li, Ting1; Li, Lin3,4; Cheng, Xiaojing3,4; Zhang, Lianhai3,4; Ji, Jiafu3,4; Wang, Pingzhang1; Han, Wenling1
刊名: SCIENTIFIC REPORTS
发表日期: 2014-10-29
DOI: 10.1038/srep06812
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: METASTATIC COLORECTAL-CANCER ; GASTRIC-CANCER ; IN-VITRO ; GENE ; RECEPTOR ; EXPRESSION ; THERAPY ; IMMUNOTHERAPY ; CHEMOTHERAPY ; P16(INK4A)
英文摘要:

Cytokines are soluble proteins that exert their functions by binding specific receptors. Many cytokines play essential roles in carcinogenesis and have been developed for the treatment of cancer. In this study, we identified a novel potential cytokine using immunogenomics designated colon-derived SUSD2 binding factor (CSBF), also known as chromosome 10 open reading frame 99 (C10orf99). CSBF/C10orf99 is a classical secreted protein with predicted molecular mass of 6.5 kDa, and a functional ligand of Sushi Domain Containing 2 (SUSD2). CSBF/C10orf99 has the highest expression level in colon tissue. Both CSBF/C10orf99 and SUSD2 are down-regulated in colon cancer tissues and cell lines with different regulation mechanisms. CSBF/C10orf99 interacts with SUSD2 to inhibit colon cancer cell growth and induce G1 cell cycle arrest by down-regulating cyclin D and cyclin-dependent kinase 6 (CDK6). CSBF/C10orf99 displays a bell-shaped activity curve with the optimal effect at similar to 10 ng/ml. Its growth inhibitory effects can be blocked by sSUSD2-Fc soluble protein. Our results suggest that CSBF/C10orf99 is a novel potential cytokine with tumor suppressor functions.

语种: 英语
所属项目编号: BMU20120316 ; 2013ZX09103003-023
项目资助者: Peking University-National Taiwan University Cooperation Fund ; Program for Innovation of New Drugs
WOS记录号: WOS:000343983600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63923
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Minist Hlth, Dept Immunol,Ctr Human Dis Genom,Key Lab Med Immu, Beijing 100871, Peoples R China
2.Peking Univ, Sch Stomatol, Cent Lab, Beijing 100871, Peoples R China
3.Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Dept Surg, Beijing 100871, Peoples R China

Recommended Citation:
Pan, Wen,Cheng, Yingying,Zhang, Heyu,et al. CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest[J]. SCIENTIFIC REPORTS,2014,4.
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