IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Conversion of cadherin isoforms in cultured human gastric carcinoma cells
Wang, Bing-Ling; Zhang, Zhi-Qian; Ke, Yang
关键词E-cadherin N-cadherin transcription factor gastric cancer
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2006-02-14
12期:6页:966-970
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]EPITHELIAL-MESENCHYMAL TRANSITIONS ; REPRESSES E-CADHERIN ; SNAIL EXPRESSION ; BREAST-CANCER ; TUMOR-METASTASIS ; ADHESION SYSTEM ; N-CADHERIN ; IN-VITRO ; INVASION ; MORPHOGENESIS
英文摘要

AIM: To explore the expression of cadherin isoforms in cultured human gastric carcinoma cells and its regulation.

METHODS: The expressions of cell adhesion molecules (including E-cadherin, N-cadherin, a-catenin, P-catenin) and cadherin transcription factors including snail, slug and twist were determined by reverse transcriptase-polymerase chain reaction(RT-PCR), immunoblotting and immunofluorescence in SV40-immortalized human gastric cell line Ges-1 and human gastric cancer cell lines MGC-803, BGC-823 and SGC-7901.

RESULTS: All cell lines expressed N-cadherin, but not E-cadherin. N-cadherin immunofluorescence was detected at cell membranous adherents junctions where co-localization with immunofluorescent staining of inner surface adhesion proteins alpha- and beta-catenins was observed. The transformed Ges-1 and gastric cancer cell lines all expressed transcription factors (snail, slug and twist) which inhibited the expression of E-cadherin and triggered epithelial-mesenchymal transformation.

CONCLUSION: Cadherin isoforms can change from E-cadherin to N-cadherin in transformed human gastric cancer cells, which is associated with intracellular events of stomach carcinogenesis and high expression of corresponding transcription factors. (c) 2006 The WJG Press. All rights reserved.

语种英语
WOS记录号WOS:000239994700021
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63924
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing 100034, Peoples R China
2.Peking Univ, Beijing Inst Canc Res, Beijing 100034, Peoples R China
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Wang, Bing-Ling,Zhang, Zhi-Qian,Ke, Yang. Conversion of cadherin isoforms in cultured human gastric carcinoma cells[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2006,12(6):966-970.
APA Wang, Bing-Ling,Zhang, Zhi-Qian,&Ke, Yang.(2006).Conversion of cadherin isoforms in cultured human gastric carcinoma cells.WORLD JOURNAL OF GASTROENTEROLOGY,12(6),966-970.
MLA Wang, Bing-Ling,et al."Conversion of cadherin isoforms in cultured human gastric carcinoma cells".WORLD JOURNAL OF GASTROENTEROLOGY 12.6(2006):966-970.
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