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学科主题: 临床医学
题名:
A systematic review and meta-analysis to reappraise the role of adjuvant hepatic arterial infusion for colorectal cancer liver metastases
作者: Liu, Wei1; Song, Qing-Kun2; Xing, Bao-Cai1
关键词: Hepatic artery infusion ; Colorectal cancer ; Metastases ; Meta-analysis
刊名: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
发表日期: 2015-08-01
DOI: 10.1007/s00384-015-2246-2
卷: 30, 期:8, 页:1091-1102
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: LONG-TERM SURVIVAL ; RANDOMIZED-TRIAL ; FOLINIC ACID ; COMPLETE RESPONSE ; CHEMOTHERAPY ; RESECTION ; OXALIPLATIN ; CARCINOMA ; 5-FLUOROURACIL ; SURGERY
英文摘要:

The potential benefit of adjuvant hepatic arterial infusion remains unknown for patients with colorectal liver metastases after radical hepatic resection. The principle aim of this study was to investigate the long-term outcome of adjuvant hepatic arterial infusion.

Eligible trials were identified from Embase, PubMed, the Web of Science, and the Cochrane library since their inception to June 1, 2014. Patients with colorectal liver metastases, who underwent radical hepatic resection and received adjuvant hepatic arterial infusion, were enrolled. The study outcomes included 5-year disease-free and overall survival rate, respectively. Hazard ratio with a 95 % confidence interval was used to measure the pooled effect according to a random effects model or fixed effects model, depending on the heterogeneity between the included studies. The statistical heterogeneity between trials was detected by I (2) test. Sensitivity analyses were also carried out.

A total of nine studies containing 1057 patients were included. The comparison indicated that the overall pooled hazard ratio for 5-year overall survival was 0.75 (95 % CI: 0.56-0.99, p = 0.048). The hazard ratio for 5-year disease-free survival rate was 0.61 (95 % CI: 0.48-0.79, p = 0.001). When compared with systemic chemotherapy alone, adjuvant hepatic arterial infusion plus systemic chemotherapy also improved the long-term survival.

Adjuvant hepatic arterial infusion improved the 5-year disease-free and overall survival rate, respectively. It should be recommended for patients with a high risk of recurrence, but these findings require prospective confirmation.

语种: 英语
WOS记录号: WOS:000358373300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63927
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Hepatopancrcatobiliary S, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Capital Med Univ Canc Ctr, Beijing Shijitan Hosp, Beijing Key Lab Canc Therapeut Vaccine, Beijing, Peoples R China

Recommended Citation:
Liu, Wei,Song, Qing-Kun,Xing, Bao-Cai. A systematic review and meta-analysis to reappraise the role of adjuvant hepatic arterial infusion for colorectal cancer liver metastases[J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,2015,30(8):1091-1102.
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