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学科主题临床医学
A systematic review and meta-analysis to reappraise the role of adjuvant hepatic arterial infusion for colorectal cancer liver metastases
Liu, Wei1; Song, Qing-Kun2; Xing, Bao-Cai1
关键词Hepatic artery infusion Colorectal cancer Metastases Meta-analysis
刊名INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
2015-08-01
DOI10.1007/s00384-015-2246-2
30期:8页:1091-1102
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]LONG-TERM SURVIVAL ; RANDOMIZED-TRIAL ; FOLINIC ACID ; COMPLETE RESPONSE ; CHEMOTHERAPY ; RESECTION ; OXALIPLATIN ; CARCINOMA ; 5-FLUOROURACIL ; SURGERY
英文摘要

The potential benefit of adjuvant hepatic arterial infusion remains unknown for patients with colorectal liver metastases after radical hepatic resection. The principle aim of this study was to investigate the long-term outcome of adjuvant hepatic arterial infusion.

Eligible trials were identified from Embase, PubMed, the Web of Science, and the Cochrane library since their inception to June 1, 2014. Patients with colorectal liver metastases, who underwent radical hepatic resection and received adjuvant hepatic arterial infusion, were enrolled. The study outcomes included 5-year disease-free and overall survival rate, respectively. Hazard ratio with a 95 % confidence interval was used to measure the pooled effect according to a random effects model or fixed effects model, depending on the heterogeneity between the included studies. The statistical heterogeneity between trials was detected by I (2) test. Sensitivity analyses were also carried out.

A total of nine studies containing 1057 patients were included. The comparison indicated that the overall pooled hazard ratio for 5-year overall survival was 0.75 (95 % CI: 0.56-0.99, p = 0.048). The hazard ratio for 5-year disease-free survival rate was 0.61 (95 % CI: 0.48-0.79, p = 0.001). When compared with systemic chemotherapy alone, adjuvant hepatic arterial infusion plus systemic chemotherapy also improved the long-term survival.

Adjuvant hepatic arterial infusion improved the 5-year disease-free and overall survival rate, respectively. It should be recommended for patients with a high risk of recurrence, but these findings require prospective confirmation.

语种英语
WOS记录号WOS:000358373300011
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63927
专题北京大学临床肿瘤学院
北京大学第三临床医学院_药剂科
北京大学临床肿瘤学院_肝胆胰外一科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Hepatopancrcatobiliary S, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Capital Med Univ Canc Ctr, Beijing Shijitan Hosp, Beijing Key Lab Canc Therapeut Vaccine, Beijing, Peoples R China
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GB/T 7714
Liu, Wei,Song, Qing-Kun,Xing, Bao-Cai. A systematic review and meta-analysis to reappraise the role of adjuvant hepatic arterial infusion for colorectal cancer liver metastases[J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,2015,30(8):1091-1102.
APA Liu, Wei,Song, Qing-Kun,&Xing, Bao-Cai.(2015).A systematic review and meta-analysis to reappraise the role of adjuvant hepatic arterial infusion for colorectal cancer liver metastases.INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,30(8),1091-1102.
MLA Liu, Wei,et al."A systematic review and meta-analysis to reappraise the role of adjuvant hepatic arterial infusion for colorectal cancer liver metastases".INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 30.8(2015):1091-1102.
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