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学科主题: 公共卫生
题名:
Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure
作者: Wang, Yun1,2,3; Wang, Bing1,2; Zhu, Mo-Tao1,2; Li, Ming1,2; Wang, Hua-Jian1,2; Wang, Meng1,2; Ouyang, Hong1,2; Chai, Zhi-Fang1,2; Feng, Wei-Yue1,2; Zhao, Yu-Liang1,2
关键词: Ferric oxide nanoparticles ; Neurotoxicity ; Microglial activation
刊名: TOXICOLOGY LETTERS
发表日期: 2011-08-10
DOI: 10.1016/j.toxlet.2011.05.001
卷: 205, 期:1, 页:26-37
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; ULTRAFINE PARTICLES ; TIO2 NANOPARTICLES ; NITRIC-OXIDE ; BRAIN ; TRANSLOCATION ; CELLS ; NANOTECHNOLOGY ; NANOTOXICOLOGY ; NEUROTOXICITY
英文摘要:

Microglia as the resident macrophage-like cells in the central nervous system (CNS) play a pivotal role in the innate immune responses of CNS. Understanding the reactions of microglia cells to nanoparticle exposure is important in the exploration of neurobiology of nanoparticles. Here we provide a systemic mapping of microglia and the corresponding pathological changes in olfactory-transport related brain areas of mice with Fe(2)O(3)-nanoparticle intranasal treatment. We showed that intranasal exposure of Fe(2)O(3) nanoparticle could lead to pathological alteration in olfactory bulb, hippocampus and striatum, and caused microglial proliferation, activation and recruitment in these areas, especially in olfactory bulb. Further experiments with BV2 microglial cells showed the exposure to Fe(2)O(3) nanoparticles could induce cells proliferation, phagocytosis and generation of ROS and NO, but did not cause significant release of inflammatory factors, including IL-1 beta, IL-6 and TNF-alpha. Our results indicate that microglial activation may act as an alarm and defense system in the processes of the exogenous nanoparticles invading and storage in brain. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011CB933403 ; KJCX3.SYW.N3 ; 10975148 ; 10905064
项目资助者: National Basic Research Program of China ; Chinese Academy of Sciences ; National Natural Science Foundation of China
WOS记录号: WOS:000293321200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63928
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Yun,Wang, Bing,Zhu, Mo-Tao,et al. Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure[J]. TOXICOLOGY LETTERS,2011,205(1):26-37.
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