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Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure
Wang, Yun1,2,3; Wang, Bing1,2; Zhu, Mo-Tao1,2; Li, Ming1,2; Wang, Hua-Jian1,2; Wang, Meng1,2; Ouyang, Hong1,2; Chai, Zhi-Fang1,2; Feng, Wei-Yue1,2; Zhao, Yu-Liang1,2
关键词Ferric oxide nanoparticles Neurotoxicity Microglial activation
刊名TOXICOLOGY LETTERS
2011-08-10
DOI10.1016/j.toxlet.2011.05.001
205期:1页:26-37
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; ULTRAFINE PARTICLES ; TIO2 NANOPARTICLES ; NITRIC-OXIDE ; BRAIN ; TRANSLOCATION ; CELLS ; NANOTECHNOLOGY ; NANOTOXICOLOGY ; NEUROTOXICITY
英文摘要

Microglia as the resident macrophage-like cells in the central nervous system (CNS) play a pivotal role in the innate immune responses of CNS. Understanding the reactions of microglia cells to nanoparticle exposure is important in the exploration of neurobiology of nanoparticles. Here we provide a systemic mapping of microglia and the corresponding pathological changes in olfactory-transport related brain areas of mice with Fe(2)O(3)-nanoparticle intranasal treatment. We showed that intranasal exposure of Fe(2)O(3) nanoparticle could lead to pathological alteration in olfactory bulb, hippocampus and striatum, and caused microglial proliferation, activation and recruitment in these areas, especially in olfactory bulb. Further experiments with BV2 microglial cells showed the exposure to Fe(2)O(3) nanoparticles could induce cells proliferation, phagocytosis and generation of ROS and NO, but did not cause significant release of inflammatory factors, including IL-1 beta, IL-6 and TNF-alpha. Our results indicate that microglial activation may act as an alarm and defense system in the processes of the exogenous nanoparticles invading and storage in brain. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000293321200004
项目编号2011CB933403 ; KJCX3.SYW.N3 ; 10975148 ; 10905064
资助机构National Basic Research Program of China ; Chinese Academy of Sciences ; National Natural Science Foundation of China
引用统计
被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63928
专题北京大学公共卫生学院
作者单位1.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yun,Wang, Bing,Zhu, Mo-Tao,et al. Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure[J]. TOXICOLOGY LETTERS,2011,205(1):26-37.
APA Wang, Yun.,Wang, Bing.,Zhu, Mo-Tao.,Li, Ming.,Wang, Hua-Jian.,...&Zhao, Yu-Liang.(2011).Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure.TOXICOLOGY LETTERS,205(1),26-37.
MLA Wang, Yun,et al."Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure".TOXICOLOGY LETTERS 205.1(2011):26-37.
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