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学科主题临床医学
Identification of miR-7 as an oncogene in renal cell carcinoma
Yu, Zuhu1,2; Ni, Liangchao1; Chen, Duqun1,2; Zhang, Qiang1,2; Su, Zhengming1,2; Wang, Yadong1,2; Yu, Wenshui1,2; Wu, Xionghui1; Ye, Jiongxian1; Yang, Shangqi1; Lai, Yongqing1; Li, Xianxin1
关键词MicroRNA miR-7 Renal cell carcinoma Oncogene
刊名JOURNAL OF MOLECULAR HISTOLOGY
2013-12-01
DOI10.1007/s10735-013-9516-5
44期:6页:669-677
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; CANCER-CELLS ; COLORECTAL-CANCER ; BREAST-CANCER ; MICRORNAS ; APOPTOSIS ; INVASION ; PROLIFERATION ; DIAGNOSIS ; DISEASE
英文摘要

MicroRNA-7 (miR-7) has been described as a tumor suppressor in several human cancers, but the results of a study to identify miRNAs associated with metastatic capability in breast cancer suggested that miR-7 may be characterized as an oncogene. The present study was to determine the expression and function of miR-7 in renal cell carcinoma. Quantitative real-time polymerase chain reaction was used to validate the expressions of miR-7 in 48 paired renal cell carcinomas (RCC) and normal tissues, based on the preliminary sequencing results of miRNAs. Furthermore, the impacts of miR-7 on cell migration, proliferation and apoptosis were analyzed using wound scratch assay, MTT and flow cytometry, respectively. The results demonstrated that miR-7 was up-regulated in RCC compared with normal tissues (p = 0.001). Down-regulation of miR-7 with synthesized inhibitor inhibited cell migration in vitro, suppressed cell proliferation and induced renal cancer cell apoptosis, prompting that miR-7 could be characterized as an oncogene in RCC. The present study was the first to reveal that miR-7 was up-regulated in RCC and it played an important role in RCC by affecting cellular migration, proliferation and apoptosis. Further researches should be conducted to explore the roles and target genes of miR-7 in RCC and other cancers.

语种英语
WOS记录号WOS:000327398200007
项目编号81101922 ; A2012584 ; S2012010008365
资助机构National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Natural Science Foundation of Guangdong Province of China
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63931
专题北京大学深圳医院
作者单位1.Peking Univ, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen PKU HKUST Med Ctr, Dept Urol,Shenzhen Hosp,Inst Urol, Shenzhen 518036, Peoples R China
2.Anhui Med Univ, Hefei 230032, Anhui, Peoples R China
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Yu, Zuhu,Ni, Liangchao,Chen, Duqun,et al. Identification of miR-7 as an oncogene in renal cell carcinoma[J]. JOURNAL OF MOLECULAR HISTOLOGY,2013,44(6):669-677.
APA Yu, Zuhu.,Ni, Liangchao.,Chen, Duqun.,Zhang, Qiang.,Su, Zhengming.,...&Li, Xianxin.(2013).Identification of miR-7 as an oncogene in renal cell carcinoma.JOURNAL OF MOLECULAR HISTOLOGY,44(6),669-677.
MLA Yu, Zuhu,et al."Identification of miR-7 as an oncogene in renal cell carcinoma".JOURNAL OF MOLECULAR HISTOLOGY 44.6(2013):669-677.
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