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学科主题: 基础医学
题名:
Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats
作者: Huang, C; Long, H; Shi, YS; Han, JS; Wan, Y
关键词: electroacupuncture ; analgesia ; tolerance ; ketamine ; NMDA receptor
刊名: NEUROSCIENCE LETTERS
发表日期: 2005-02-28
DOI: 10.1016/j.neulet.2004.10.086
卷: 375, 期:2, 页:138-142
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: OPIOID RECEPTOR AGONIST ; MORPHINE-TOLERANCE ; NMDA-RECEPTOR ; NEUROPATHIC PAIN ; ANALGESIA ; MODEL ; MICE ; MK-801 ; DEXTROMETHORPHAN ; ACUPUNCTURE
英文摘要:

Our previous studies have shown that 100 Hz electroacupuncture (EA) produced antinociception through the release of endogenous opioids (mainly dynorphin) and the activated K-opioid receptors in normal rats. Acupuncture is an effective treatment in relieving pain, but it develops tolerance after repeated administration. It has been reported that N-methyl-D-aspartate (NMDA) receptor antagonists could increase the antinociceptive effects induced by morphine and delay the development of tolerance to morphine but nothing has yet been described to reduce EA tolerance. Here we test whether ketamine, a non-competitive NMDA receptor antagonist, would enhance 100 Hz EA antinociception as well as prevent or delay the development of chronic tolerance to 100 Hz EA in normal rats. The results are as follows: (1) ketamine injected intraperitoneally (i.p.) 15 min prior to EA enhanced the antinociceptive effects of 100 Hz EA at a dose of 5.0 mg/kg, but not 0.2 or 1.0 mg/kg. However, ketamine at either dose did not affect the basal nociceptive threshold (represented by tail-flick latency). (2) Ketamine at a dose of 5.0 mg/kg delayed the development of chronic tolerance to 100 Hz EA antinociception. We conclude that ketamine can enhance antinociception of 100 Hz EA and delay the tolerance to 100 Hz EA in rats. These results suggest that the development of 100 Hz EA tolerance to antinociception was mediated, at least in part, through peripheral NMDA receptors, which may be useful in improving the therapeutic effects of EA in the treatment of pain when EA tolerance occurs. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000227014100014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63933
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
2.Gannan Med Coll, Dept Physiol, Ganzhou 341000, Peoples R China

Recommended Citation:
Huang, C,Long, H,Shi, YS,et al. Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats[J]. NEUROSCIENCE LETTERS,2005,375(2):138-142.
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