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学科主题基础医学
Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats
Huang, C; Long, H; Shi, YS; Han, JS; Wan, Y
关键词electroacupuncture analgesia tolerance ketamine NMDA receptor
刊名NEUROSCIENCE LETTERS
2005-02-28
DOI10.1016/j.neulet.2004.10.086
375期:2页:138-142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]OPIOID RECEPTOR AGONIST ; MORPHINE-TOLERANCE ; NMDA-RECEPTOR ; NEUROPATHIC PAIN ; ANALGESIA ; MODEL ; MICE ; MK-801 ; DEXTROMETHORPHAN ; ACUPUNCTURE
英文摘要

Our previous studies have shown that 100 Hz electroacupuncture (EA) produced antinociception through the release of endogenous opioids (mainly dynorphin) and the activated K-opioid receptors in normal rats. Acupuncture is an effective treatment in relieving pain, but it develops tolerance after repeated administration. It has been reported that N-methyl-D-aspartate (NMDA) receptor antagonists could increase the antinociceptive effects induced by morphine and delay the development of tolerance to morphine but nothing has yet been described to reduce EA tolerance. Here we test whether ketamine, a non-competitive NMDA receptor antagonist, would enhance 100 Hz EA antinociception as well as prevent or delay the development of chronic tolerance to 100 Hz EA in normal rats. The results are as follows: (1) ketamine injected intraperitoneally (i.p.) 15 min prior to EA enhanced the antinociceptive effects of 100 Hz EA at a dose of 5.0 mg/kg, but not 0.2 or 1.0 mg/kg. However, ketamine at either dose did not affect the basal nociceptive threshold (represented by tail-flick latency). (2) Ketamine at a dose of 5.0 mg/kg delayed the development of chronic tolerance to 100 Hz EA antinociception. We conclude that ketamine can enhance antinociception of 100 Hz EA and delay the tolerance to 100 Hz EA in rats. These results suggest that the development of 100 Hz EA tolerance to antinociception was mediated, at least in part, through peripheral NMDA receptors, which may be useful in improving the therapeutic effects of EA in the treatment of pain when EA tolerance occurs. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000227014100014
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63933
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
2.Gannan Med Coll, Dept Physiol, Ganzhou 341000, Peoples R China
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GB/T 7714
Huang, C,Long, H,Shi, YS,et al. Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats[J]. NEUROSCIENCE LETTERS,2005,375(2):138-142.
APA Huang, C,Long, H,Shi, YS,Han, JS,&Wan, Y.(2005).Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats.NEUROSCIENCE LETTERS,375(2),138-142.
MLA Huang, C,et al."Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats".NEUROSCIENCE LETTERS 375.2(2005):138-142.
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