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rAAV-mediated delivery of brain-derived neurotrophic factor promotes neurite outgrowth and protects neurodegeneration in focal ischemic model
Zhang, Jingyu1,2; Yu, Zhigang3; Yu, Zhiqiang4; Yang, Zichao2; Zhao, Hong2; Liu, Luran2; Zhao, Jiexu1
关键词Stroke recombinant adeno-associated virus brain-derived neurotrophic factor gene therapy
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2011
4期:5页:496-504
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]CEREBRAL-ARTERY OCCLUSION ; FACTOR RECEPTOR EGFR ; GROWTH-FACTOR ; INFARCT SIZE ; PHOSPHATIDYLINOSITOL 3-KINASE ; BDNF PROTECTS ; NEURONS ; NEUROPROTECTION ; PREVENTS ; KINASE
英文摘要

Stroke is one of the neurological diseases which lead to permanently neuronal damage after temporary or long-term occlusion of vessels or after heart attack. However, there are few efficient strategies to prevent or treat this kind of insult in clinical because the consequence is irreversible and could be long-lasting after the onset of stroke. Gene therapy especially using viral system has long been addressed to be of great potential to reduce the damage. Here, we generated recombinant adeno-associated virus (rAAV) carrying brain-derived neurotrophic factor (BDNF) gene. Cells infected with rAAV-BDNF could be able to produce functional BDNF which promoted neurite outgrowth and protected neurons from apoptosis induced by serum deprivation. Further more, single injection of rAAV showed neuroprotection against cell death in focal ischemic model. These results showed that rAAV-mediated gene delivery is functional, which shed light to the future application of viral system-based gene therapy in clinical.

语种英语
WOS记录号WOS:000293511100006
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63934
专题北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China
2.Jilin Univ, Hosp 1, Dept Neurol, Changchun 130021, Jilin, Peoples R China
3.Harbin Med Coll, Hosp 4, Dept Neurol, Harbin 150001, Heilongjiang, Peoples R China
4.Jilin Univ, Hosp 1, Dept Anesthesiol, Changchun 130021, Jilin, Peoples R China
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Zhang, Jingyu,Yu, Zhigang,Yu, Zhiqiang,et al. rAAV-mediated delivery of brain-derived neurotrophic factor promotes neurite outgrowth and protects neurodegeneration in focal ischemic model[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2011,4(5):496-504.
APA Zhang, Jingyu.,Yu, Zhigang.,Yu, Zhiqiang.,Yang, Zichao.,Zhao, Hong.,...&Zhao, Jiexu.(2011).rAAV-mediated delivery of brain-derived neurotrophic factor promotes neurite outgrowth and protects neurodegeneration in focal ischemic model.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,4(5),496-504.
MLA Zhang, Jingyu,et al."rAAV-mediated delivery of brain-derived neurotrophic factor promotes neurite outgrowth and protects neurodegeneration in focal ischemic model".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 4.5(2011):496-504.
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