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学科主题: 临床医学
题名:
Comparison of Diffusion-Weighted with T2-weighted Imaging for Detection of Small Hepatocellular Carcinoma in Cirrhosis: Preliminary Quantitative Study at 3-T
作者: Wang, Hua1,2; Wang, Xiao-Ying1; Jiang, Xue-Xiang1; Ye, Zhao-Xiang2
关键词: Diffusion-weighted imaging ; magnetic resonance ; hepatocellular carcinoma ; cirrhosis
刊名: ACADEMIC RADIOLOGY
发表日期: 2010-02-01
DOI: 10.1016/j.acra.2009.09.012
卷: 17, 期:2, 页:239-243
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: ECHO-PLANAR MR ; LIVER LESION DETECTION ; FOCAL HEPATIC-LESIONS ; BREATH-HOLD ; INITIAL-EXPERIENCE ; 3.0 T ; SEQUENCES ; ECHOPLANAR ; DIAGNOSIS ; FIBROSIS
英文摘要:

Rationale and Objectives: To compare diffusion-weighted (DW) with standard T2-weighted imaging for quantitative evaluation of small hepatocellular carcinoma (HCC) in cirrhosis.

Materials and Methods: Fourteen patients (all men; mean age, 58.6 years; age range, 45-69 years) with 22 small HCCs (<3 cm and >1 cm in diameter) in cirrhosis were included in the study. DW imaging with breath-hold single-shot echo planar imaging (b = 0, 800 seconds/mm(2)) and T2-weighted imaging with respiratory triggering fat-suppressed fast spin-echo sequence were performed on a 3-T magnetic resonance unit using an eight-channel torso phased-array coil. The signal intensity (SI) of HCC and liver were measured at workstation. Contrast-to-noise ratio (CNR), contrast ratio (CR, Sl(lesion)/Sl(liver)), and apparent diffusion coefficient (ADC) values were calculated. CNRs and CRs obtained with DW and T2-weighted images, and ADCs of HCC and liver were compared using nonparametric tests.

Results: Two lesions were excluded because of artifacts on DW images. Thus 20 lesions were analyzed. The CNRs obtained with T2-weighted images (27.12 +/- 21.12) were significantly higher (P = .02) than those with DW images (17.52 +/- 13.50). There were no significant difference between the CRs obtained with T2-weighted images (1.83 +/- 0.56) and DW images (2.01 +/- 0.67). There were no significant difference between the mean ADCs of HCC (1.22 x 10(-3) mm(2)/second +/- 0.24) and the cirrhotic liver (1.17 x 10(-3) mm(2)/second +/- 0.17), either.

Conclusion: DW imaging with high b value was not superior to standard T2-weighted imaging in terms of lesion conspicuity of small HCC in cirrhosis.

语种: 英语
WOS记录号: WOS:000273834100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63935
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
2.Tianjin Med Univ, Canc Inst & Hosp, Dept Radiol, Tianjin 300060, Peoples R China

Recommended Citation:
Wang, Hua,Wang, Xiao-Ying,Jiang, Xue-Xiang,et al. Comparison of Diffusion-Weighted with T2-weighted Imaging for Detection of Small Hepatocellular Carcinoma in Cirrhosis: Preliminary Quantitative Study at 3-T[J]. ACADEMIC RADIOLOGY,2010,17(2):239-243.
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