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学科主题: 公共卫生
题名:
Detection of dicofol and related pesticides in human breast milk from China, Korea and Japan
作者: Fujii, Yukiko10; Haraguchi, Koichi1; Harada, Kouji H.10; Hitomi, Toshiaki10; Inoue, Kayoko10; Itoh, Yoshiko1; Watanabe, Takao2; Takenaka, Katsunobu3; Uehara, Shigeki4; Yang, Hye-Ran5; Kim, Min-Young5; Moon, Chan-Seok6; Kim, Hae-Sook7; Wang, Peiyu8; Liu, Aiping8; Nguyen Ngoc Hung9; Koizumi, Akio10
关键词: Human milk ; DDTs ; Dicofol ; Japan ; Korea ; China
刊名: CHEMOSPHERE
发表日期: 2011
DOI: 10.1016/j.chemosphere.2010.10.036
卷: 82, 期:1, 页:25-31
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
关键词[WOS]: POLYBROMINATED DIPHENYL ETHERS ; ORGANOCHLORINE PESTICIDES ; PERSISTENT ORGANOCHLORINES ; POLYCHLORINATED-BIPHENYLS ; CONTINUOUS SURVEILLANCE ; HONG-KONG ; DDT ; EXPOSURE ; CONTAMINATION ; RESIDUES
英文摘要:

Previously, we demonstrated that the concentrations of DDTs were greater in breast milk collected from Chinese mothers than from Japanese and Korean mothers. To investigate dicofol as a possible source of the DDTs in human breast milk, we collected breast milk samples from 2007 to 2009 in China (Beijing), Korea (Seoul, Busan) and Japan (Sendai, Takarazuka and Takayama). Using these breast milk samples, we quantified the concentrations of dichlorobenzophenone, a pyrolysis product of dicofol (simply referred to as dicofol hereafter), dichlorodiphenyltrichloroethane and its metabolites (DDTs) using GC-MS. Overall, 12 of 14 pooled breast milk samples from 210 mothers contained detectable levels of dicofol (>0.1 ng g(-1) lipid). The geometric mean concentration of dicofol in the Japanese breast milk samples was 0.3 ng g(-1) lipid and significantly lower than that in Chinese (9.6 ng g(-1) lipid) or Korean breast milk samples (1.9 ng g(-1) lipid) (p < 0.05 for each). Furthermore, the Sigma DDT levels in breast milk from China were 10-fold higher than those from Korea and Japan. The present results strongly suggest the presence of extensive emission sources of both dicofol and DDTs in China. However, exposure to dicofol cannot explain the large exposure of Chinese mothers to DDTs because of the trace levels of dicofol in the DDTs. In the present study, dicofol was confirmed to be detectable in human breast milk. This is the first report to identify dicofol in human samples. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 1300001 ; H21-Food-003
项目资助者: Japan Science and Technology Agency ; Ministry of Health, Labour and Welfare of Japan ; KOSEF-JSPS
WOS记录号: WOS:000286016800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63943
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Daiichi Coll Pharmaceut Sci, Minami Ku, Fukuoka 8158511, Japan
2.Miyagi Univ Educ, Sendai, Miyagi 9800845, Japan
3.Takayama Red Cross Hosp, Dept Neurosurg, Takayama 5068550, Japan
4.Tohoku Kosai Hosp, Dept Obstet & Gynecol, Sendai, Miyagi 9800803, Japan
5.Seoul Metropolitan Govt, Res Inst Publ Hlth & Environm, Yongjae Seoul 137734, South Korea
6.Catholic Univ Pusan, Dept Ind Hlth, Pusan 609757, South Korea
7.Kyung Hee Univ, Coll Nursing Sci, Seoul 130701, South Korea
8.Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100083, Peoples R China
9.Hanoi Med Univ, Dept Sci & Technol, Hanoi, SR, Vietnam
10.Kyoto Univ, Dept Hlth & Environm Sci, Grad Sch Med, Yoshida Sakyo Kyoto 6068501, Japan

Recommended Citation:
Fujii, Yukiko,Haraguchi, Koichi,Harada, Kouji H.,et al. Detection of dicofol and related pesticides in human breast milk from China, Korea and Japan[J]. CHEMOSPHERE,2011,82(1):25-31.
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