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学科主题: 临床医学
题名:
Molecular characterisation of outbreak-related strains of vancomycin-resistant Enterococcus faecium from an intensive care unit in Beijing, China
作者: Zhu, X.2; Zheng, B.1; Wang, S.1; Willems, R. J. L.3; Xue, F.1; Cao, X.2; Li, Y.1; Bo, S.2; Liu, J.1
关键词: Enterococcus faecium ; Intensive care unit ; Multilocus sequence typing ; Tn1546 ; Vancomycin-resistant enterococci
刊名: JOURNAL OF HOSPITAL INFECTION
发表日期: 2009-06-01
DOI: 10.1016/j.jhin.2009.02.014
卷: 72, 期:2, 页:147-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: STREPTOCOCCUS-FAECALIS ; MAINLAND CHINA ; HUMANS ; DIVERSITY ; ELEMENTS ; PLASMID
英文摘要:

We investigated an outbreak of vancomycin-resistant Enterococcus faecium affecting 14 patients in a 20-bed intensive care unit (ICU) between September 2006 and August 2007 (incidence: 3.56 cases per 1000 ICU patient days). Eighteen isolates of vanA type E. faecium were analysed by pulsed field gel electrophoresis, which showed 14 types overall. Multilocus sequence typing (MLST) identified eight different sequence types (STs) (ST78, ST117, ST203, ST316, ST362, ST363, ST364 and ST365), including four new types (ST362, ST363, ST364 and ST365) and 17 strains belonged to clonal complexes CC17. Sixteen of these carried the esp gene. Eighteen Tn1546-like elements encoding vanA-type VRE were classified into three types (types I to III) and all of them contained both IS1216V and IS1542 insertions. Vancomycin resistance of 14 vanA type E. faecium isolates was transferred at a frequency of 1.3 x 10(-6) to 6.4 x 10(-5) between E. faecium strains during filter mating. Our findings indicate that conjugative dissemination of Tn1546-like elements among CC17 E. faecium occurred during the outbreak in this ICU. (C) 2009 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000266645100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63946
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100034, Peoples R China
2.Peking Univ, Dept Crit Care Med, Hosp 3, Beijing 100871, Peoples R China
3.Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

Recommended Citation:
Zhu, X.,Zheng, B.,Wang, S.,et al. Molecular characterisation of outbreak-related strains of vancomycin-resistant Enterococcus faecium from an intensive care unit in Beijing, China[J]. JOURNAL OF HOSPITAL INFECTION,2009,72(2):147-154.
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