IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所
学科主题临床医学
Molecular characterisation of outbreak-related strains of vancomycin-resistant Enterococcus faecium from an intensive care unit in Beijing, China
Zhu, X.2; Zheng, B.1; Wang, S.1; Willems, R. J. L.3; Xue, F.1; Cao, X.2; Li, Y.1; Bo, S.2; Liu, J.1
关键词Enterococcus faecium Intensive care unit Multilocus sequence typing Tn1546 Vancomycin-resistant enterococci
刊名JOURNAL OF HOSPITAL INFECTION
2009-06-01
DOI10.1016/j.jhin.2009.02.014
72期:2页:147-154
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]STREPTOCOCCUS-FAECALIS ; MAINLAND CHINA ; HUMANS ; DIVERSITY ; ELEMENTS ; PLASMID
英文摘要

We investigated an outbreak of vancomycin-resistant Enterococcus faecium affecting 14 patients in a 20-bed intensive care unit (ICU) between September 2006 and August 2007 (incidence: 3.56 cases per 1000 ICU patient days). Eighteen isolates of vanA type E. faecium were analysed by pulsed field gel electrophoresis, which showed 14 types overall. Multilocus sequence typing (MLST) identified eight different sequence types (STs) (ST78, ST117, ST203, ST316, ST362, ST363, ST364 and ST365), including four new types (ST362, ST363, ST364 and ST365) and 17 strains belonged to clonal complexes CC17. Sixteen of these carried the esp gene. Eighteen Tn1546-like elements encoding vanA-type VRE were classified into three types (types I to III) and all of them contained both IS1216V and IS1542 insertions. Vancomycin resistance of 14 vanA type E. faecium isolates was transferred at a frequency of 1.3 x 10(-6) to 6.4 x 10(-5) between E. faecium strains during filter mating. Our findings indicate that conjugative dissemination of Tn1546-like elements among CC17 E. faecium occurred during the outbreak in this ICU. (C) 2009 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000266645100008
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63946
专题北京大学第一临床医学院_临床药理研究所
作者单位1.Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100034, Peoples R China
2.Peking Univ, Dept Crit Care Med, Hosp 3, Beijing 100871, Peoples R China
3.Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands
推荐引用方式
GB/T 7714
Zhu, X.,Zheng, B.,Wang, S.,et al. Molecular characterisation of outbreak-related strains of vancomycin-resistant Enterococcus faecium from an intensive care unit in Beijing, China[J]. JOURNAL OF HOSPITAL INFECTION,2009,72(2):147-154.
APA Zhu, X..,Zheng, B..,Wang, S..,Willems, R. J. L..,Xue, F..,...&Liu, J..(2009).Molecular characterisation of outbreak-related strains of vancomycin-resistant Enterococcus faecium from an intensive care unit in Beijing, China.JOURNAL OF HOSPITAL INFECTION,72(2),147-154.
MLA Zhu, X.,et al."Molecular characterisation of outbreak-related strains of vancomycin-resistant Enterococcus faecium from an intensive care unit in Beijing, China".JOURNAL OF HOSPITAL INFECTION 72.2(2009):147-154.
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