IR@PKUHSC  > 北京大学第三临床医学院  > 眼科
学科主题临床医学
CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury
Huang, Ping1; Huo, Yanjiao1; Lou, Lucy X.2; Li, Hong2; Barnstable, Colin J.2,3; Zhang, Chun1; Zhang, Samuel S.2,3,4
关键词retinal ganglion cell immune T helper cell severe combined immunodeficient mice neuroprotection ischemia STAT6
刊名EXPERIMENTAL EYE RESEARCH
2013-10-01
DOI10.1016/j.exer.2013.06.015
115页:131-139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]NECROSIS-FACTOR-ALPHA ; HEAT-SHOCK PROTEINS ; OPEN-ANGLE GLAUCOMA ; OPTIC-NERVE HEAD ; BRAIN-INJURY ; CEREBRAL-ISCHEMIA ; NEURONAL SURVIVAL ; STAT3 ACTIVATION ; IMMUNE-SYSTEM ; REGENERATION
英文摘要

Neuron degeneration is a common pathological process associated with many disease conditions in the central nervous system including retina. Although immune responses have been proposed as one potential element in triggering neural damage, the mechanism of action of specific immune components underlying the pathogenesis is unclear. In this study we focus on adaptive immune activities to evaluate CD4 positive helper cells in the retinal ganglion cell (RGC) degeneration in response to transient retinal ischemic/reperfusion (I/R) injury. Transient retinal ischemia was induced in four mouse strains with different immune backgrounds, including wild type mice from C57BL/6 and BABL/c strains, severe combined immunodeficient (SCID) mice lacking T and B lymphocytes, SCID mice with transferred wild type CD4+ T cells, and the STAT6 deficient mice without T helper 2 (TH2) cells. In SCID mice RGCs showed a strong resistance to cell death in response to I/R injury (89% +/- 3% of the survival cells in contralateral eye) compared with C57BL/6 (p = 0.018) and BALB/C (p = 0.038) wild types. By transferring the mature CD4+ T cells from matched wild type into SCID mice, the resistance of RGCs to injury was significantly compromised (p < 0.05). Furthermore a significant resistance of RGCs to cell death (p < 0.05) accompanied with an overexpression of STAT1 and STAT3 was confirmed in STAT6 deficient mice in response to I/R injury compared with the wild type controls, indicating that TH2 cells maturation might be involved in RGC damage. Adaptive immunity carried by CD4 T cells plays an essential role in RGC degeneration. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000326060600017
项目编号30772376 ; 81041008 ; EY 013865
资助机构Chinese State Natural and Science ; NIH ; PA Sight Conservation Eye Research ; Frontiers in Eye and Vision Research Award of Penn State University
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63952
专题北京大学第三临床医学院_眼科
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Peking Univ Hosp 3, Ctr Eye, Dept Ophthalmol, Beijing 100191, Peoples R China
2.Penn State Univ, Dept Neural & Behav Sci, Hershey, PA 17033 USA
3.Penn State Univ, Penn State Hershey Eye Ctr, Hershey, PA 17033 USA
4.Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 168751, Singapore
推荐引用方式
GB/T 7714
Huang, Ping,Huo, Yanjiao,Lou, Lucy X.,et al. CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury[J]. EXPERIMENTAL EYE RESEARCH,2013,115:131-139.
APA Huang, Ping.,Huo, Yanjiao.,Lou, Lucy X..,Li, Hong.,Barnstable, Colin J..,...&Zhang, Samuel S..(2013).CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury.EXPERIMENTAL EYE RESEARCH,115,131-139.
MLA Huang, Ping,et al."CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury".EXPERIMENTAL EYE RESEARCH 115(2013):131-139.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, Ping]的文章
[Huo, Yanjiao]的文章
[Lou, Lucy X.]的文章
百度学术
百度学术中相似的文章
[Huang, Ping]的文章
[Huo, Yanjiao]的文章
[Lou, Lucy X.]的文章
必应学术
必应学术中相似的文章
[Huang, Ping]的文章
[Huo, Yanjiao]的文章
[Lou, Lucy X.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。