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学科主题: 临床医学
题名:
CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury
作者: Huang, Ping1; Huo, Yanjiao1; Lou, Lucy X.2; Li, Hong2; Barnstable, Colin J.2,3; Zhang, Chun1; Zhang, Samuel S.2,3,4
关键词: retinal ganglion cell ; immune ; T helper cell ; severe combined immunodeficient mice ; neuroprotection ; ischemia ; STAT6
刊名: EXPERIMENTAL EYE RESEARCH
发表日期: 2013-10-01
DOI: 10.1016/j.exer.2013.06.015
卷: 115, 页:131-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; HEAT-SHOCK PROTEINS ; OPEN-ANGLE GLAUCOMA ; OPTIC-NERVE HEAD ; BRAIN-INJURY ; CEREBRAL-ISCHEMIA ; NEURONAL SURVIVAL ; STAT3 ACTIVATION ; IMMUNE-SYSTEM ; REGENERATION
英文摘要:

Neuron degeneration is a common pathological process associated with many disease conditions in the central nervous system including retina. Although immune responses have been proposed as one potential element in triggering neural damage, the mechanism of action of specific immune components underlying the pathogenesis is unclear. In this study we focus on adaptive immune activities to evaluate CD4 positive helper cells in the retinal ganglion cell (RGC) degeneration in response to transient retinal ischemic/reperfusion (I/R) injury. Transient retinal ischemia was induced in four mouse strains with different immune backgrounds, including wild type mice from C57BL/6 and BABL/c strains, severe combined immunodeficient (SCID) mice lacking T and B lymphocytes, SCID mice with transferred wild type CD4+ T cells, and the STAT6 deficient mice without T helper 2 (TH2) cells. In SCID mice RGCs showed a strong resistance to cell death in response to I/R injury (89% +/- 3% of the survival cells in contralateral eye) compared with C57BL/6 (p = 0.018) and BALB/C (p = 0.038) wild types. By transferring the mature CD4+ T cells from matched wild type into SCID mice, the resistance of RGCs to injury was significantly compromised (p < 0.05). Furthermore a significant resistance of RGCs to cell death (p < 0.05) accompanied with an overexpression of STAT1 and STAT3 was confirmed in STAT6 deficient mice in response to I/R injury compared with the wild type controls, indicating that TH2 cells maturation might be involved in RGC damage. Adaptive immunity carried by CD4 T cells plays an essential role in RGC degeneration. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30772376 ; 81041008 ; EY 013865
项目资助者: Chinese State Natural and Science ; NIH ; PA Sight Conservation Eye Research ; Frontiers in Eye and Vision Research Award of Penn State University
WOS记录号: WOS:000326060600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63952
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 3, Ctr Eye, Dept Ophthalmol, Beijing 100191, Peoples R China
2.Penn State Univ, Dept Neural & Behav Sci, Hershey, PA 17033 USA
3.Penn State Univ, Penn State Hershey Eye Ctr, Hershey, PA 17033 USA
4.Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 168751, Singapore

Recommended Citation:
Huang, Ping,Huo, Yanjiao,Lou, Lucy X.,et al. CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury[J]. EXPERIMENTAL EYE RESEARCH,2013,115:131-139.
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