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The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients
Yang, Rui; Du, Xiaoguo; Wang, Ying; Song, Xueling; Yang, Yan; Qiao, Jie
关键词Chronic endometritis Histological Hysteroscopy Recurrent implantation failure
刊名ARCHIVES OF GYNECOLOGY AND OBSTETRICS
2014-06-01
DOI10.1007/s00404-013-3131-2
289期:6页:1363-1369
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]IN-VITRO FERTILIZATION ; PRETERM BIRTH ; UTERINE CAVITY ; WOMEN ; TRIAL
英文摘要

To study the consistency of hysteroscopy findings and histological chronic endometritis (CE) in recurrent implantation failure (RIF) cases, and to compare their values in indicating antibiotic treatment.

Sixty RIF cases (January 2009-January 2010) and 202 consecutive RIF cases (May 2010-April 2012) in Peking University Third Hospital reproductive medical center were studied. 60 RIF patients′ endometrial samples redid section and CD38/CD138 immunohistochemical stain for CE screening. In 202 RIF cases, the presence of hyperemia, mucosal edema, and micropolyps under hysteroscopy were considered CE diagnostic parameters. Antibiotic was offered to part of the patients. The patients′ clinical outcomes were analyzed by statistical methods.

In 202 RIF cases, the hysteroscopy CE rate was 66.3 %, while histological CE rate was 43.6 %. The sensitivity and specificity of hysteroscopy were 35.2 and 67.5 %. In histological CE patients, 68 cases underwent regular antibiotic treatment and 20 did not. Two groups had similar clinical pregnancy rates (35.3 vs. 30.0 %), embryo implantation rates (18.9 vs. 20.4 %) and ongoing pregnancy rates (29.4 vs. 25.0 %). In hysteroscopy CE patients, the implantation rate (18.6 vs. 4.9 %) and ongoing pregnancy rate (29.3 vs. 7.4 %) significantly increased (P < 0.05) with antibiotic treatment, and higher intrauterine pregnancy rate in treatment group (29.3 vs. 11.1 %). In reviewing the chosen 60 RIF cases, the histological CE rates were similar in both pregnancy and non-pregnancy group after subsequent embryo transfer.

CE occurs frequently in RIF patients; hysteroscopy has more diagnostic and treatment value for them.

语种英语
WOS记录号WOS:000336394600035
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63953
专题北京大学临床肿瘤学院_药剂科
北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Rui,Du, Xiaoguo,Wang, Ying,et al. The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients[J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS,2014,289(6):1363-1369.
APA Yang, Rui,Du, Xiaoguo,Wang, Ying,Song, Xueling,Yang, Yan,&Qiao, Jie.(2014).The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients.ARCHIVES OF GYNECOLOGY AND OBSTETRICS,289(6),1363-1369.
MLA Yang, Rui,et al."The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients".ARCHIVES OF GYNECOLOGY AND OBSTETRICS 289.6(2014):1363-1369.
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