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学科主题: 临床医学
题名:
The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients
作者: Yang, Rui; Du, Xiaoguo; Wang, Ying; Song, Xueling; Yang, Yan; Qiao, Jie
关键词: Chronic endometritis ; Histological ; Hysteroscopy ; Recurrent implantation failure
刊名: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
发表日期: 2014-06-01
DOI: 10.1007/s00404-013-3131-2
卷: 289, 期:6, 页:1363-1369
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: IN-VITRO FERTILIZATION ; PRETERM BIRTH ; UTERINE CAVITY ; WOMEN ; TRIAL
英文摘要:

To study the consistency of hysteroscopy findings and histological chronic endometritis (CE) in recurrent implantation failure (RIF) cases, and to compare their values in indicating antibiotic treatment.

Sixty RIF cases (January 2009-January 2010) and 202 consecutive RIF cases (May 2010-April 2012) in Peking University Third Hospital reproductive medical center were studied. 60 RIF patients′ endometrial samples redid section and CD38/CD138 immunohistochemical stain for CE screening. In 202 RIF cases, the presence of hyperemia, mucosal edema, and micropolyps under hysteroscopy were considered CE diagnostic parameters. Antibiotic was offered to part of the patients. The patients′ clinical outcomes were analyzed by statistical methods.

In 202 RIF cases, the hysteroscopy CE rate was 66.3 %, while histological CE rate was 43.6 %. The sensitivity and specificity of hysteroscopy were 35.2 and 67.5 %. In histological CE patients, 68 cases underwent regular antibiotic treatment and 20 did not. Two groups had similar clinical pregnancy rates (35.3 vs. 30.0 %), embryo implantation rates (18.9 vs. 20.4 %) and ongoing pregnancy rates (29.4 vs. 25.0 %). In hysteroscopy CE patients, the implantation rate (18.6 vs. 4.9 %) and ongoing pregnancy rate (29.3 vs. 7.4 %) significantly increased (P < 0.05) with antibiotic treatment, and higher intrauterine pregnancy rate in treatment group (29.3 vs. 11.1 %). In reviewing the chosen 60 RIF cases, the histological CE rates were similar in both pregnancy and non-pregnancy group after subsequent embryo transfer.

CE occurs frequently in RIF patients; hysteroscopy has more diagnostic and treatment value for them.

语种: 英语
WOS记录号: WOS:000336394600035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63953
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Rui,Du, Xiaoguo,Wang, Ying,et al. The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients[J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS,2014,289(6):1363-1369.
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