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学科主题基础医学
The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer
Chi, Yingkai; Zhao, Jing; Cui, Su-Ping; Jiang, Ping; Wang, Hua-Li; Zhang, Hong; Mao, Jing-Zhuo; Liu, Hai-Jing; Hou, Lin; Zhang, Bo
关键词pAkt CerbB2 ILK DNA-PK Breast cancer
刊名HISTOLOGY AND HISTOPATHOLOGY
2013-05-01
28期:5页:655-661
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
资助者Chinese National Natural Science Foundation ; Research Fund for the Doctoral Program of Higher Education ; Chinese National Natural Science Foundation ; Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]INTEGRIN-LINKED KINASE ; PROTEIN-KINASE ; DNA-PK ; HER2 ; PATHWAY ; IMMUNOHISTOCHEMISTRY ; CARCINOMA ; SURVIVAL ; THERAPY ; TARGETS
英文摘要

Although some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.

语种英语
所属项目编号30770830 ; 200800010060
资助者Chinese National Natural Science Foundation ; Research Fund for the Doctoral Program of Higher Education ; Chinese National Natural Science Foundation ; Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000317749100011
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63954
专题基础医学院_病理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chi, Yingkai,Zhao, Jing,Cui, Su-Ping,et al. The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer[J]. HISTOLOGY AND HISTOPATHOLOGY,2013,28(5):655-661.
APA Chi, Yingkai.,Zhao, Jing.,Cui, Su-Ping.,Jiang, Ping.,Wang, Hua-Li.,...&Zhang, Bo.(2013).The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer.HISTOLOGY AND HISTOPATHOLOGY,28(5),655-661.
MLA Chi, Yingkai,et al."The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer".HISTOLOGY AND HISTOPATHOLOGY 28.5(2013):655-661.
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