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学科主题: 基础医学
题名:
The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer
作者: Chi, Yingkai; Zhao, Jing; Cui, Su-Ping; Jiang, Ping; Wang, Hua-Li; Zhang, Hong; Mao, Jing-Zhuo; Liu, Hai-Jing; Hou, Lin; Zhang, Bo
关键词: pAkt ; CerbB2 ; ILK ; DNA-PK ; Breast cancer
刊名: HISTOLOGY AND HISTOPATHOLOGY
发表日期: 2013-05-01
卷: 28, 期:5, 页:655-661
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: INTEGRIN-LINKED KINASE ; PROTEIN-KINASE ; DNA-PK ; HER2 ; PATHWAY ; IMMUNOHISTOCHEMISTRY ; CARCINOMA ; SURVIVAL ; THERAPY ; TARGETS
英文摘要:

Although some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.

语种: 英语
所属项目编号: 30770830 ; 200800010060
项目资助者: Chinese National Natural Science Foundation ; Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000317749100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63954
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Chi, Yingkai,Zhao, Jing,Cui, Su-Ping,et al. The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer[J]. HISTOLOGY AND HISTOPATHOLOGY,2013,28(5):655-661.
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