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学科主题: 临床医学
题名:
The expression of TTF-1 and Napsin A in early-stage lung adenocarcinoma correlates with the results of surgical treatment
作者: Ma, Yunfan1; Fan, Mengying1; Dai, Liang1; Kang, Xiaozheng1; Liu, Yiqiang2; Sun, Yu2; Yan, Wanpu1; Liang, Zhen1; Xiong, Hongchao1; Chen, Keneng1
关键词: Lung cancer ; Biomarkers ; Prognosis ; Diagnosis ; Adenocarcinoma
刊名: TUMOR BIOLOGY
发表日期: 2015-09-01
DOI: 10.1007/s13277-015-3478-z
卷: 36, 期:10, 页:8085-8092
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TRANSCRIPTION FACTOR-I ; INTERNATIONAL MULTIDISCIPLINARY CLASSIFICATION ; SQUAMOUS-CELL CARCINOMA ; MONOCLONAL-ANTIBODIES ; PROGNOSTIC-FACTOR ; CANCER ; ASSOCIATION ; SUBCLASSIFICATION ; DIFFERENTIATION ; CYTOKERATINS
英文摘要:

Non-small cell lung cancer (NSCLC) accounts for 80 % of lung cancers, and lung adenocarcinoma (ADC) is one of the main types of NSCLC. Although there are several studies on the relationship between lung ADC immunohistochemical diagnostic markers (thyroid transcription factor 1 (TTF-1) and Napsin A) and survival, some aspects of those studies could be improved. We examined the significance of the commonly used lung ADC diagnostic markers, including TTF-1, Napsin A, and CK7, in the prognosis of early-stage lung ADC. One hundred and nineteen cases of early-stage lung ADC (N-0) were selected from the prospective database of lung cancer (Jan 2000 to Dec 2009). The expression levels of TTF-1, Napsin A, and CK7 in inventoried specimens were analyzed using tissue microarray (TMA) and immunohistochemical (IHC) analysis, and the effect of the expression level of each marker on patients′ survival was examined. The diagnostic sensitivity and specificity of each marker for lung ADC were as follows: TTF-1, 87.0 and 90.1 %; Napsin A, 72.2 and 90.4 %; and CK7, 94.6 and 76.0 %, respectively. Patients with high expression levels of TTF-1 and Napsin A, and high co-expression levels of TTF-1/Napsin A had better survival rates than those with low levels of expression (P < 0.05). The expression levels of CK7 were not related to patients′ survival. Multivariate analysis showed that the expression levels of Napsin A and TTF-1/Napsin A are independent prognostic factors for survival. The IHC detection of TTF-1 and Napsin A in specimens should be routinely performed in postoperative early-stage lung ADC patients. Its significance lies not only in the differential diagnosis, but also in determining the prognosis.

语种: 英语
所属项目编号: 2009-2-17 ; 7102029 ; 2007-1023 ; 2011CB504300 ; 20130001110108 ; 81301748 ; IRT13003
项目资助者: Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Found ; New Scholar Star Program of the Ministry of Education ; National Basic Research Program of China (973 programs) ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation ; Education Ministry Innovative Research Team in University
WOS记录号: WOS:000362969900083
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63957
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 1, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Recommended Citation:
Ma, Yunfan,Fan, Mengying,Dai, Liang,et al. The expression of TTF-1 and Napsin A in early-stage lung adenocarcinoma correlates with the results of surgical treatment[J]. TUMOR BIOLOGY,2015,36(10):8085-8092.
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