北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Monocytic and promyelocytic myeloid-derived suppressor cells may contribute to G-CSF-induced immune tolerance in haplo-identical allogeneic hematopoietic stem cell transplantation
作者: Lv, Meng1; Zhao, Xiao-Su1; Hu, Yue1,2; Chang, Ying-Jun1; Zhao, Xiang-Yu1; Kong, Yuan1; Zhang, Xiao-Hui1; Xu, Lan-Ping1; Liu, Kai-Yan1; Huang, Xiao-Jun1,2
刊名: AMERICAN JOURNAL OF HEMATOLOGY
发表日期: 2015
DOI: 10.1002/ajh.23865
卷: 90, 期:1, 页:E9-E16
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; COLONY-STIMULATING FACTOR ; CHRONIC GRAFT ; BLOOD GRAFTS ; TH17 CELLS ; RISK ; LEUKEMIA ; DONORS ; MALIGNANCIES
英文摘要:

We investigated the effects of granulocyte colony-stimulating factor (G-CSF) on monocytic (M), promyelocytic (P), and granulocytic (G) myeloid-derived suppressor cells (MDSCs) both in bone marrow and peripheral blood of 20 healthy donors and the association of MDSCs subgroups with acute and chronic graft-versus-host disease (aGvHD/cGvHD) in 62 patients who underwent haplo-identical allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patients who received a higher absolute counts of MMDSCs or P-MDSCs exhibited lower incidence of grade II-IV aGvHD (P = 0.001; P = 0.031) and extensive cGvHD (P = 0.011; P = 0.021). In the multivariate analysis, absolute counts of MDSCs in allografts emerged as independent factors that reduced the occurrence of grade II-IV aGvHD (M-MDSCs: HR = 0.087, 95% CI = 0.020-0.381, P = 0.001; P-MDSCs: HR = 0.357, 95% CI = 0.139-0.922, P = 0.033) and extensive cGvHD (MMDSCs: HR = 0.196, 95% CI = 0.043-0.894, P = 0.035; P-MDSCs: HR = 0.257, 95% CI = 0.070-0.942, P = 0.04). Delayed M-MDSC reconstitution was associated with aGvHD onset. The 3-year cumulative incidence of transplant related mortality and relapse, 3-year probability of disease-free survival, and overall survival did not differ significantly between these subgroups. Our results suggested that G-CSF-induced immune tolerance may be mediated by M/P-MDSCs in allo-HSCT. (C) 2014 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 81230013 ; 81400146 ; 81300440 ; 7122193 ; Z141100000214011
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Beijing Municipal Science and Technology Program
WOS记录号: WOS:000346771400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63962
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China

Recommended Citation:
Lv, Meng,Zhao, Xiao-Su,Hu, Yue,et al. Monocytic and promyelocytic myeloid-derived suppressor cells may contribute to G-CSF-induced immune tolerance in haplo-identical allogeneic hematopoietic stem cell transplantation[J]. AMERICAN JOURNAL OF HEMATOLOGY,2015,90(1):E9-E16.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lv, Meng]'s Articles
[Zhao, Xiao-Su]'s Articles
[Hu, Yue]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lv, Meng]‘s Articles
[Zhao, Xiao-Su]‘s Articles
[Hu, Yue]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace