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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Monocytic and promyelocytic myeloid-derived suppressor cells may contribute to G-CSF-induced immune tolerance in haplo-identical allogeneic hematopoietic stem cell transplantation
作者: Lv, Meng1; Zhao, Xiao-Su1; Hu, Yue1,2; Chang, Ying-Jun1; Zhao, Xiang-Yu1; Kong, Yuan1; Zhang, Xiao-Hui1; Xu, Lan-Ping1; Liu, Kai-Yan1; Huang, Xiao-Jun1,2
刊名: AMERICAN JOURNAL OF HEMATOLOGY
发表日期: 2015
DOI: 10.1002/ajh.23865
卷: 90, 期:1, 页:E9-E16
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; COLONY-STIMULATING FACTOR ; CHRONIC GRAFT ; BLOOD GRAFTS ; TH17 CELLS ; RISK ; LEUKEMIA ; DONORS ; MALIGNANCIES
英文摘要:

We investigated the effects of granulocyte colony-stimulating factor (G-CSF) on monocytic (M), promyelocytic (P), and granulocytic (G) myeloid-derived suppressor cells (MDSCs) both in bone marrow and peripheral blood of 20 healthy donors and the association of MDSCs subgroups with acute and chronic graft-versus-host disease (aGvHD/cGvHD) in 62 patients who underwent haplo-identical allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patients who received a higher absolute counts of MMDSCs or P-MDSCs exhibited lower incidence of grade II-IV aGvHD (P = 0.001; P = 0.031) and extensive cGvHD (P = 0.011; P = 0.021). In the multivariate analysis, absolute counts of MDSCs in allografts emerged as independent factors that reduced the occurrence of grade II-IV aGvHD (M-MDSCs: HR = 0.087, 95% CI = 0.020-0.381, P = 0.001; P-MDSCs: HR = 0.357, 95% CI = 0.139-0.922, P = 0.033) and extensive cGvHD (MMDSCs: HR = 0.196, 95% CI = 0.043-0.894, P = 0.035; P-MDSCs: HR = 0.257, 95% CI = 0.070-0.942, P = 0.04). Delayed M-MDSC reconstitution was associated with aGvHD onset. The 3-year cumulative incidence of transplant related mortality and relapse, 3-year probability of disease-free survival, and overall survival did not differ significantly between these subgroups. Our results suggested that G-CSF-induced immune tolerance may be mediated by M/P-MDSCs in allo-HSCT. (C) 2014 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 81230013 ; 81400146 ; 81300440 ; 7122193 ; Z141100000214011
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Beijing Municipal Science and Technology Program
WOS记录号: WOS:000346771400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63962
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China

Recommended Citation:
Lv, Meng,Zhao, Xiao-Su,Hu, Yue,et al. Monocytic and promyelocytic myeloid-derived suppressor cells may contribute to G-CSF-induced immune tolerance in haplo-identical allogeneic hematopoietic stem cell transplantation[J]. AMERICAN JOURNAL OF HEMATOLOGY,2015,90(1):E9-E16.
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