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The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study
Prince, Martin1,2; Acosta, Daisy3; Ferri, Cleusa P.1,2; Guerra, Mariella4,5; Huang, Yueqin6; Jacob, K. S.7; Jotheeswaran, A. T.1,2; Liu, Zhaorui6; Rodriguez, Juan J. Llibre8; Salas, Aquiles9; Sosa, Ana Luisa10; Williams, Joseph D.11
关键词dementia comorbidity vision disorders hearing disorders nutrition disorders urinary incontinence
刊名INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
2011-05-01
DOI10.1002/gps.2558
26期:5页:511-519
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology ; Gerontology ; Psychiatry
资助者Wellcome Trust ; US Alzheimer&prime ; s Association ; FONDACIT (Venezuela) ; Wellcome Trust ; US Alzheimer&prime ; s Association ; FONDACIT (Venezuela)
研究领域[WOS]Geriatrics & Gerontology ; Psychiatry
关键词[WOS]ALZHEIMERS-DISEASE ; HEARING IMPAIRMENT ; AGGRESSION ; PREVALENCE ; MANAGEMENT ; DECLINE ; WEIGHT ; HEALTH ; TRIAL ; CARE
英文摘要

Objective: Chronic physical comorbidity is common in dementia. However, there is an absence of evidence to support good practice guidelines for attention to these problems. We aimed to study the extent of this comorbidity and its impact on cognitive function and disability in population-based studies in low and middle income countries, where chronic diseases and impairments are likely to be both common and undertreated.

Methods: A multicentre cross-sectional survey of all over 65 year old residents (n = 15 022) in 11 catchment areas in China, India, Cuba, Dominican Republic, Venezuela, Mexico and Peru. We estimated the prevalence of pain, incontinence, hearing and visual impairments, mobility impairment and undernutrition according to the presence of dementia and its severity, and, among those with dementia, the independent contribution of these impairments to cognitive function and disability, adjusting for age, gender, education and dementia severity.

Results: Incontinence, hearing impairment, mobility impairment and undernutrition were consistently linearly associated with the presence of dementia and its severity across regions. Among people with dementia, incontinence, hearing impairment and mobility impairment were independently associated with disability in all regions while the contributions of pain, visual impairment and undernutrition were inconsistent. Only hearing impairment made a notable independent contribution to cognitive impairment.

Conclusions: There is an urgent need for clinical trials of the feasibility, efficacy and cost-effectiveness of regular physical health checks and remediation of identified pathologies, given the considerable comorbidity identified in our population based studies, and the strong evidence for independent impact upon functioning. Copyright (c) 2010 John Wiley & Sons, Ltd.

语种英语
所属项目编号GR066133 ; GR08002 ; IIRG - 04 -1286
资助者Wellcome Trust ; US Alzheimer&prime ; s Association ; FONDACIT (Venezuela) ; Wellcome Trust ; US Alzheimer&prime ; s Association ; FONDACIT (Venezuela)
WOS记录号WOS:000288997400009
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63963
Collection北京大学精神卫生研究所
作者单位1.Inst Memoria & Desordenes Relacionados, Lima, Peru
2.Med Univ Havana, Fac Med Finley Albarran, Havana, Cuba
3.Voluntary Hlth Serv, Madras, Tamil Nadu, India
4.UNPHU, Internal Med Dept, Geriatr Sect, Santo Domingo, Dominican Rep
5.Univ Peruana Cayetano Heredia, Lima, Peru
6.Kings Coll London, Inst Psychiat, Ctr Global Mental Hlth, Hlth Serv, London, England
7.Kings Coll London, Inst Psychiat, Ctr Global Mental Hlth, Populat Res Dept, London, England
8.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100871, Peoples R China
9.Christian Med Coll & Hosp, Vellore, Tamil Nadu, India
10.Cent Univ Venezuela, Caracas Univ Hosp, Fac Med, Dept Med, Caracas, Venezuela
11.Univ Nacl Autonoma Mexico, Natl Inst Neurol & Neurosurg Mexico, Cognit & Behav Unit, Mexico City 04510, DF, Mexico
Recommended Citation
GB/T 7714
Prince, Martin,Acosta, Daisy,Ferri, Cleusa P.,et al. The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study[J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY,2011,26(5):511-519.
APA Prince, Martin.,Acosta, Daisy.,Ferri, Cleusa P..,Guerra, Mariella.,Huang, Yueqin.,...&Williams, Joseph D..(2011).The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study.INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY,26(5),511-519.
MLA Prince, Martin,et al."The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study".INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 26.5(2011):511-519.
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