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学科主题: 精神卫生
题名:
The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study
作者: Prince, Martin1,2; Acosta, Daisy3; Ferri, Cleusa P.1,2; Guerra, Mariella4,5; Huang, Yueqin6; Jacob, K. S.7; Jotheeswaran, A. T.1,2; Liu, Zhaorui6; Rodriguez, Juan J. Llibre8; Salas, Aquiles9; Sosa, Ana Luisa10; Williams, Joseph D.11
关键词: dementia ; comorbidity ; vision disorders ; hearing disorders ; nutrition disorders ; urinary incontinence
刊名: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
发表日期: 2011-05-01
DOI: 10.1002/gps.2558
卷: 26, 期:5, 页:511-519
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology ; Gerontology ; Psychiatry
研究领域[WOS]: Geriatrics & Gerontology ; Psychiatry
关键词[WOS]: ALZHEIMERS-DISEASE ; HEARING IMPAIRMENT ; AGGRESSION ; PREVALENCE ; MANAGEMENT ; DECLINE ; WEIGHT ; HEALTH ; TRIAL ; CARE
英文摘要:

Objective: Chronic physical comorbidity is common in dementia. However, there is an absence of evidence to support good practice guidelines for attention to these problems. We aimed to study the extent of this comorbidity and its impact on cognitive function and disability in population-based studies in low and middle income countries, where chronic diseases and impairments are likely to be both common and undertreated.

Methods: A multicentre cross-sectional survey of all over 65 year old residents (n = 15 022) in 11 catchment areas in China, India, Cuba, Dominican Republic, Venezuela, Mexico and Peru. We estimated the prevalence of pain, incontinence, hearing and visual impairments, mobility impairment and undernutrition according to the presence of dementia and its severity, and, among those with dementia, the independent contribution of these impairments to cognitive function and disability, adjusting for age, gender, education and dementia severity.

Results: Incontinence, hearing impairment, mobility impairment and undernutrition were consistently linearly associated with the presence of dementia and its severity across regions. Among people with dementia, incontinence, hearing impairment and mobility impairment were independently associated with disability in all regions while the contributions of pain, visual impairment and undernutrition were inconsistent. Only hearing impairment made a notable independent contribution to cognitive impairment.

Conclusions: There is an urgent need for clinical trials of the feasibility, efficacy and cost-effectiveness of regular physical health checks and remediation of identified pathologies, given the considerable comorbidity identified in our population based studies, and the strong evidence for independent impact upon functioning. Copyright (c) 2010 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: GR066133 ; GR08002 ; IIRG - 04 -1286
项目资助者: Wellcome Trust ; US Alzheimer&prime ; s Association ; FONDACIT (Venezuela)
WOS记录号: WOS:000288997400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63963
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Inst Memoria & Desordenes Relacionados, Lima, Peru
2.Med Univ Havana, Fac Med Finley Albarran, Havana, Cuba
3.Voluntary Hlth Serv, Madras, Tamil Nadu, India
4.UNPHU, Internal Med Dept, Geriatr Sect, Santo Domingo, Dominican Rep
5.Univ Peruana Cayetano Heredia, Lima, Peru
6.Kings Coll London, Inst Psychiat, Ctr Global Mental Hlth, Hlth Serv, London, England
7.Kings Coll London, Inst Psychiat, Ctr Global Mental Hlth, Populat Res Dept, London, England
8.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100871, Peoples R China
9.Christian Med Coll & Hosp, Vellore, Tamil Nadu, India
10.Cent Univ Venezuela, Caracas Univ Hosp, Fac Med, Dept Med, Caracas, Venezuela
11.Univ Nacl Autonoma Mexico, Natl Inst Neurol & Neurosurg Mexico, Cognit & Behav Unit, Mexico City 04510, DF, Mexico

Recommended Citation:
Prince, Martin,Acosta, Daisy,Ferri, Cleusa P.,et al. The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study[J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY,2011,26(5):511-519.
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