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学科主题基础医学
RNF122 Induces Cell Apoptosis Dependent on Its RING Domain
Peng Zhi1,3; Ji Zhao-Ning1,3; Shi Tai-Ping1,2; Ma Da-Long1,2
关键词RING domain RNF122 cell apoptosis ERK pathway
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
2011-09-01
DOI10.3724/SP.J.1206.2010.00680
38期:9页:816-820
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]FINGER ; LIGASE ; CANCER ; MOTIF
英文摘要

RNF122 is a novel gene which can inhibit cellular growth and induce apoptosis. RNF122 contains a RING-H2 domain. RING domain mutant was constructed to explore the relationship between RING domain and apoptosis. MTT and apoptosis experiments revealed that RNF122 closely related to cell viability dependent on its RING domain. Further exploration implied that RNF122 can negatively regulate ERK pathway, whereas RING domain mutant RNF122 can enhance the phosphorylation of ERK. It can be concluded that RNF122 may regulate cellular viability through ERK pathway. In short, RING domain is critical to the function of RNF122.

语种中文
WOS记录号WOS:000295248500006
项目编号30600547 ; 2006AA02A305 ; 2009ZX09503-004
资助机构The National Natural Science Foundation of China ; High-Tech Research and Development Program of China ; The Key National S& ; T Program-"Major New Drug Development"
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63964
专题北京大学基础医学院_免疫学系
作者单位1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China
3.Yijishan Hosp, Wannan Med Coll, Dept Med Oncol, Wuhu 241001, Peoples R China
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Peng Zhi,Ji Zhao-Ning,Shi Tai-Ping,et al. RNF122 Induces Cell Apoptosis Dependent on Its RING Domain[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2011,38(9):816-820.
APA Peng Zhi,Ji Zhao-Ning,Shi Tai-Ping,&Ma Da-Long.(2011).RNF122 Induces Cell Apoptosis Dependent on Its RING Domain.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,38(9),816-820.
MLA Peng Zhi,et al."RNF122 Induces Cell Apoptosis Dependent on Its RING Domain".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 38.9(2011):816-820.
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