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学科主题: 基础医学
题名:
RNF122 Induces Cell Apoptosis Dependent on Its RING Domain
作者: Peng Zhi1,3; Ji Zhao-Ning1,3; Shi Tai-Ping1,2; Ma Da-Long1,2
关键词: RING domain ; RNF122 ; cell apoptosis ; ERK pathway
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2011-09-01
DOI: 10.3724/SP.J.1206.2010.00680
卷: 38, 期:9, 页:816-820
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: FINGER ; LIGASE ; CANCER ; MOTIF
英文摘要:

RNF122 is a novel gene which can inhibit cellular growth and induce apoptosis. RNF122 contains a RING-H2 domain. RING domain mutant was constructed to explore the relationship between RING domain and apoptosis. MTT and apoptosis experiments revealed that RNF122 closely related to cell viability dependent on its RING domain. Further exploration implied that RNF122 can negatively regulate ERK pathway, whereas RING domain mutant RNF122 can enhance the phosphorylation of ERK. It can be concluded that RNF122 may regulate cellular viability through ERK pathway. In short, RING domain is critical to the function of RNF122.

语种: 中文
所属项目编号: 30600547 ; 2006AA02A305 ; 2009ZX09503-004
项目资助者: The National Natural Science Foundation of China ; High-Tech Research and Development Program of China ; The Key National S& ; T Program-"Major New Drug Development"
WOS记录号: WOS:000295248500006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63964
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China
3.Yijishan Hosp, Wannan Med Coll, Dept Med Oncol, Wuhu 241001, Peoples R China

Recommended Citation:
Peng Zhi,Ji Zhao-Ning,Shi Tai-Ping,et al. RNF122 Induces Cell Apoptosis Dependent on Its RING Domain[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2011,38(9):816-820.
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