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学科主题: 精神卫生
题名:
Association between polymorphisms in serotonin 2C receptor gene and attention-deficit/hyperactivity disorder in Han Chinese subjects
作者: Li, Jun; Wang, Yufeng; Zhou, Rulun; Zhang, Haobo; Yang, Li; Wang, Bing; Faraone, Stephen V.
关键词: gene ; ADHD ; serotonin ; receptor ; polymorphism ; linkage disequilibrium ; haplotype
刊名: NEUROSCIENCE LETTERS
发表日期: 2006-10-23
DOI: 10.1016/j.neulet.2006.08.022
卷: 407, 期:2, 页:107-111
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; MONOAMINE-OXIDASE-A ; PROMOTER-REGION ; 5-HT2C RECEPTORS ; ADHD ; IDENTIFICATION ; POPULATION ; PREVALENCE ; LOCOMOTOR ; CHILDREN
英文摘要:

Attention deficit hyperactivity disorder (ADHD) is much more frequent in males than females, so several genes on the X chromosome (e.g., MAOA and MAOB) have been pursued as candidates for influencing risk for the disorder. HTR2C is also located on the X chromosome. In the current study, we examined the relationship between the C-759T and G-697C polymorphisms of HTR2C and ADHD in 488 Han Chinese families. Transmission Disequilibrium Test (TDT) analysis showed that the -759C allele, the -697G allele, and haplotype -759C/-697G were significantly over-transmitted to affected probands, while haplotypes -759C/-697C and -759T/-697C were under-transmitted. When families were divided into three subtypes according to the diagnosis of probands, the -697G allele and haplotype -759C/-697G were significantly over transmitted to ADHD-C probands, while haplotype -759T/-697C was under-transmitted to these individuals; however, no biased transmission of any allele or haplotype was observed for probands with ADHD-I, suggesting that different subtypes of ADHD have different genetic influences. Our findings highlight the need to explore the role of 5-HT2C receptor dysfunction in the pathogenesis of ADHD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000241250400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63966
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA

Recommended Citation:
Li, Jun,Wang, Yufeng,Zhou, Rulun,et al. Association between polymorphisms in serotonin 2C receptor gene and attention-deficit/hyperactivity disorder in Han Chinese subjects[J]. NEUROSCIENCE LETTERS,2006,407(2):107-111.
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